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The map label for this gene is sucD [H]

Identifier: 218692341

GI number: 218692341

Start: 4733627

End: 4734499

Strand: Direct

Name: sucD [H]

Synonym: ECED1_4774

Alternate gene names: 218692341

Gene position: 4733627-4734499 (Clockwise)

Preceding gene: 218692340

Following gene: 218692342

Centisome position: 90.86

GC content: 51.55

Gene sequence:

>873_bases
ATGAGCGTTTTGATCAACAAACACACGCGGGTACTGGTGCAGGGCATTACCGGCAAAAACGGCACATTTCATACAGAGCA
GGCTATTGCGTATGGCACGCAGATTGTGGGTGGAGTGACGCCAGGTAAGGGCGGGCAACGGCATCTGGATCGCCCGGTTT
TTGATTCAATGAAAGAAGCGATGCGACAAACTGAGGCTGATGCCAGCGTGATTTATGTGCCTGCACCGTTTGTGCTGGAT
TCTGTTGTTGAGGCTATTGAAGCTGGCGTCAAATTGGTTGTGGTGATCACTGAAGGTGTACCGACACTGGATATGGTGAA
AGTTCGTCGGCTGCTTGACTGCCACCCGGATGTGCGGCTGATTGGGCCAAACTGCCCAGGAGTTATCACGCCGGGCGAGT
GCAAAATCGGGATTATGCCTGGTGAAATCCACCGCCCAGGGCGTATTGGGATTGTTTCCCGCTCCGGTACATTAACCTAC
GAAGCTGTAGCGCAAACCACGGCGCTGGGACTTGGGCAATCCACCTGTATTGGTATTGGCGGCGATCCGGTTCCGGGGAC
TAACTTTATTGATGCGCTGCGTTTATTCGAAAATGATCCGCAAACAGACGCGGTAATTATGATCGGTGAAATTGGTGGTA
ATGCGGAAGAACGGGCCGCGGAATTTATTCGTGATGAAATGAATAAACCGGTCGTAGGTTATATTGCCGGTGTTACTGCA
CCAAAAGGAAAACGCATGGGGCACGCCGGAGCCATTATTTCTGGCGGTAGCGGCAGTGCAGAGGATAAATTCCGTGCGTT
CGATAAAGCAGGCATGGCATGGACAAGAAACCCGGCGTTGCTTGGCGAAACGTTATGGAATGTTATTAAGTAA

Upstream 100 bases:

>100_bases
GCGGTTACTGGCAGAAAGTGGCCTGACGGTGGAAGCCGTCAATTCTCTGGATGATGCCGCTAAACGCATCATTGCGTTAC
TGAATTAACAGGAGGTTAAG

Downstream 100 bases:

>100_bases
TCCATAAATGAATATCAAGGGAGCATATCGCTCCCTTTTTTTATCTGTGTGGTAAGAGAATCACCTTTTATTTACTGTGC
GGAAAACCGCGCACAAAATA

Product: Succinyl-CoA synthetase subunit alpha (SCS-alpha)

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQRHLDRPVFDSMKEAMRQTEADASVIYVPAPFVLD
SVVEAIEAGVKLVVVITEGVPTLDMVKVRRLLDCHPDVRLIGPNCPGVITPGECKIGIMPGEIHRPGRIGIVSRSGTLTY
EAVAQTTALGLGQSTCIGIGGDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRDEMNKPVVGYIAGVTA
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK

Sequences:

>Translated_290_residues
MSVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQRHLDRPVFDSMKEAMRQTEADASVIYVPAPFVLD
SVVEAIEAGVKLVVVITEGVPTLDMVKVRRLLDCHPDVRLIGPNCPGVITPGECKIGIMPGEIHRPGRIGIVSRSGTLTY
EAVAQTTALGLGQSTCIGIGGDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRDEMNKPVVGYIAGVTA
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK
>Mature_289_residues
SVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQRHLDRPVFDSMKEAMRQTEADASVIYVPAPFVLDS
VVEAIEAGVKLVVVITEGVPTLDMVKVRRLLDCHPDVRLIGPNCPGVITPGECKIGIMPGEIHRPGRIGIVSRSGTLTYE
AVAQTTALGLGQSTCIGIGGDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRDEMNKPVVGYIAGVTAP
KGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=61.5916955017301, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI38569421, Length=314, Percent_Identity=28.343949044586, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI38569423, Length=314, Percent_Identity=28.343949044586, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1786949, Length=290, Percent_Identity=67.5862068965517, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=57.5342465753425, Blast_Score=318, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=57.8947368421053, Blast_Score=313, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI17557344, Length=247, Percent_Identity=32.3886639676113, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=227, Percent_Identity=33.0396475770925, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=49.8305084745763, Blast_Score=281, Evalue=7e-77,
Organism=Drosophila melanogaster, GI21356559, Length=286, Percent_Identity=58.041958041958, Blast_Score=354, Evalue=5e-98,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=57.5862068965517, Blast_Score=313, Evalue=7e-86,
Organism=Drosophila melanogaster, GI281363477, Length=258, Percent_Identity=28.2945736434109, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363475, Length=258, Percent_Identity=28.2945736434109, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363473, Length=258, Percent_Identity=28.2945736434109, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30678; Mature: 30547

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQRHLDRPVFDSMKEA
CCEEECCCEEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHH
MRQTEADASVIYVPAPFVLDSVVEAIEAGVKLVVVITEGVPTLDMVKVRRLLDCHPDVRL
HHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEE
IGPNCPGVITPGECKIGIMPGEIHRPGRIGIVSRSGTLTYEAVAQTTALGLGQSTCIGIG
ECCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCEEEECC
GDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRDEMNKPVVGYIAGVTA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCC
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK
CCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQRHLDRPVFDSMKEA
CEEECCCEEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHH
MRQTEADASVIYVPAPFVLDSVVEAIEAGVKLVVVITEGVPTLDMVKVRRLLDCHPDVRL
HHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEE
IGPNCPGVITPGECKIGIMPGEIHRPGRIGIVSRSGTLTYEAVAQTTALGLGQSTCIGIG
ECCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCEEEECC
GDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRDEMNKPVVGYIAGVTA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCC
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK
CCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]