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The map label for this gene is lyxK [H]

Identifier: 218691870

GI number: 218691870

Start: 4189150

End: 4190646

Strand: Direct

Name: lyxK [H]

Synonym: ECED1_4269

Alternate gene names: 218691870

Gene position: 4189150-4190646 (Clockwise)

Preceding gene: 218691869

Following gene: 218691871

Centisome position: 80.41

GC content: 56.78

Gene sequence:

>1497_bases
ATGACGCAATACTGGCTGGGGTTAGATTGTGGCGGTAGCTGGCTGAAAGCCGGGCTGTATGACCGAGAAGGCCGGGAGGC
GGGCGTGCAGCGCCTGCCGCTGTGCGCATTAAGTCCACAGCCAGGCTGGGCAGAGCGCGACATGGCAGAACTGTGGCAAT
GTTGCACTGCTGTCATTCGCGCCCTGCTTACCCATTCCGGCGTCAGCGGGGAACAAATTGTCGGTATCGGCATCTCCGCG
CAGGGAAAGGGCTTATTTCTACTTGATAAAAACGACAAACCGCTCGGTAACGCCATTTTGTCCTCGGATCGCCGGGCGAT
GGAAATCGTTCGTCGCTGGCAGGAAGATGGCATCCCGGAAAAACTCTATCCGCTGACCCGACAAACCTTATGGACCGGGC
ATCCGGTGTCGCTGTTACGCTGGCTGAAAGAGCACGAACCAGAACGCTACGCGCAAATTGGCTGCGTGATGATGACGCAC
GACTACCTGCGCTGGTGTTTAACCGGCGTCAAAGGTTGCGAAGAGAGCAATATTTCTGAGTCCAATCTCTACAACATGAG
TCGCGGGGAATATGACCCGTGCCTTACCGACTGGCTGGGGATTGCTGAAATCAATCACGCCCTGCCGCCTGTTGTCGGAT
CTGCCGAAATCTGCGGGGAAATCACCGCTCAGACAGCCGTACTGACCGGTCTGAAAGCGGGTACCCCCGTTGTCGGCGGC
CTGTTTGATGTGGTTTCCACCGCACTCTGCGCCGGGCTCGAAGACGAATTCACCCTCAATGCGGTGATGGGGACCTGGGC
GGTGACCAGCGGCATAACCCACGGTTTACGTGATGGTGAAGCGCATCCGTATGTCTATGGTCGCTACGTTAACGATGGTC
AATTTATCGTTCACGAAGCCAGCCCCACCTCTTCCGGCAATCTCGAATGGTTTACCGCACAGTGGGGAGAAATCTCATTT
GCTGAGATTAATCAGGCCGTAGCCAGTTTGCCGAAAGCCGGTGGCGATCTCTTTTTCCTGCCGTTCCTGTACGGCAGCAA
CGCCGGACTCGAAATGACCAGCGGTTTCTACGGGATGCAGGCCATTCACACCCGTGCACACCTCTTACAGGCTATCTATG
AAGGGGTGGTGTTCAGCCATATGACCCATCTCAACCGGATGCGCGAACGTTTTACTGATGTGCACACCCTGCGCGTCACT
GGCGGCCCGGCGCACTCCGATGTCTGGATGCAAATGCTGGCGGACGTCAGCGGTCTGCGTATCGAGCTGCCGCAGGTGGA
AGAAACCGGCTGCTTTGGTGCGGCACTTGCCGCCCGCGTCGGTACCGGGGTTTATCGCGATTTCAGCGAAGCCCAACGTG
ACTTACAGCACCCGGTACGCACCCTGCTGCCGAATATGGCCGCGCATCAGCTTTACCAACAAAAATACCAACGCTATCAA
CATCTCATTGCCGCACTTCAGGGTTATCACACCCGCATCAAGGAGCACACATTATGA

Upstream 100 bases:

>100_bases
CTTTAGCGATGCGCTGGGTACCCAGGTCCGTGACATGTTTGTTAAAGATGTTCCGCAGGGTGCTGATCTGCTGAAAGCCG
TGGATGAGGTGCAATAAACC

Downstream 100 bases:

>100_bases
GTCGACCACTTCTGCAACTGGCCCTCGACCACTCATCACTTGAAGCCGCGCAGCGCGACGTGACGCGGTTAAAAGACAGC
GTCGATATTGTCGAAGCAGG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIRALLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISF
AEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPNMAAHQLYQQKYQRYQ
HLIAALQGYHTRIKEHTL

Sequences:

>Translated_498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIRALLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISF
AEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPNMAAHQLYQQKYQRYQ
HLIAALQGYHTRIKEHTL
>Mature_497_residues
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIRALLTHSGVSGEQIVGIGISAQ
GKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHD
YLRWCLTGVKGCEESNISESNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGGL
FDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEASPTSSGNLEWFTAQWGEISFA
EINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPNMAAHQLYQQKYQRYQH
LIAALQGYHTRIKEHTL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=487, Percent_Identity=24.435318275154, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI164663828, Length=548, Percent_Identity=23.3576642335766, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=96.9879518072289, Blast_Score=1006, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=25.1485148514851, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789987, Length=484, Percent_Identity=23.9669421487603, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790361, Length=476, Percent_Identity=23.5294117647059, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24655555, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655560, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655570, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655574, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655565, Length=454, Percent_Identity=24.6696035242291, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24656367, Length=519, Percent_Identity=23.3140655105973, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357867, Length=531, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656372, Length=175, Percent_Identity=27.4285714285714, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24657106, Length=557, Percent_Identity=23.1597845601436, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24657102, Length=557, Percent_Identity=23.1597845601436, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 55139; Mature: 55008

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIR
CCCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHH
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGEISFAEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPNMAAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLIAALQGYHTRIKEHTL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCTAVIR
CCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHH
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMSRGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGLEDEFTLNAVMGTWAVTSGITHGLRDGEAHPYVYGRYVNDGQFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGEISFAEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPNMAAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLIAALQGYHTRIKEHTL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]