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The map label for this gene is ompR

Identifier: 218691682

GI number: 218691682

Start: 3967951

End: 3968670

Strand: Reverse

Name: ompR

Synonym: ECED1_4065

Alternate gene names: 218691682

Gene position: 3968670-3967951 (Counterclockwise)

Preceding gene: 218691688

Following gene: 218691681

Centisome position: 76.18

GC content: 54.86

Gene sequence:

>720_bases
ATGCAAGAGAACTACAAGATTCTGGTGGTTGATGACGACATGCGCCTGCGCGCGCTGCTGGAACGTTATCTCACCGAACA
AGGCTTCCAGGTTCGAAGCGTCGCTAATGCAGAACAGATGGATCGCCTGCTGACTCGTGAATCTTTCCATCTTATGGTAC
TGGATTTGATGTTACCTGGTGAAGATGGCTTGTCGATTTGCCGACGTCTTCGTAGCCAGAGCAATCCGATGCCGATCATT
ATGGTGACGGCGAAAGGGGAAGAAGTGGACCGTATCGTTGGCCTGGAGATTGGCGCTGACGATTACATTCCAAAACCGTT
TAACCCGCGTGAACTGCTGGCCCGCATTCGTGCGGTGCTGCGTCGTCAGGCGAATGAACTGCCAGGCGCACCGTCACAGG
AAGAGGCGGTAATTGCTTTCGGTAAGTTCAAACTTAACCTCGGTACGCGCGAAATGTTCCGCGAAGACGAGCCGATGCCG
CTCACCAGTGGTGAGTTTGCGGTACTTAAGGCGCTGGTCAGCCATCCGCGTGAGCCGCTCTCCCGCGATAAGCTGATGAA
CCTTGCCCGTGGTCGTGAATATTCCGCAATGGAACGCTCCATCGACGTGCAGATTTCGCGTCTGCGCCGCATGGTGGAAG
AAGATCCGGCGCATCCGCGTTACATTCAGACCGTCTGGGGTCTGGGCTACGTCTTTGTACCGGACGGTTCTAAAGCATGA

Upstream 100 bases:

>100_bases
ATTTAGGCTGAAATTCATACCAGATTTAGCTGGTGACGAACGTGAGCTTTTTTAAGAATACACGCTTACAAATTGTTGCG
AACCTTTGGGAGTACAAACA

Downstream 100 bases:

>100_bases
GGCGATTGCGCTTCTCGCCACGAAGTTCATTTGCCCGTACGTTATTGCTCATCGTCACCTTGCTGTTCGTCAGCCTGGTG
ACGACTTATCTGGTGGTGCT

Product: osmolarity response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPII
MVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMP
LTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA

Sequences:

>Translated_239_residues
MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPII
MVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMP
LTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA
>Mature_239_residues
MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPII
MVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMP
LTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA

Specific function: The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and ompC; its C-terminal moiety mediates the multimerization of the ompR protein. As a multimer, it turns on the expression of th

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1789809, Length=239, Percent_Identity=100, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=37.4468085106383, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=37.5545851528384, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=36.0515021459227, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI2367329, Length=235, Percent_Identity=40.4255319148936, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=37.5, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=34.4827586206897, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=35.6521739130435, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=33.4745762711864, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=34.6491228070175, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=33.9285714285714, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=231, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=32.7510917030568, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=31.2775330396476, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=30.0813008130081, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=29.4117647058824, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OMPR_ECO57 (P0AA18)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   F86005
- PIR:   G91159
- RefSeq:   NP_289945.1
- RefSeq:   NP_312274.1
- ProteinModelPortal:   P0AA18
- SMR:   P0AA18
- PRIDE:   P0AA18
- EnsemblBacteria:   EBESCT00000024060
- EnsemblBacteria:   EBESCT00000055432
- GeneID:   915896
- GeneID:   957766
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4760
- KEGG:   ecs:ECs4247
- GeneTree:   EBGT00050000008651
- HOGENOM:   HBG753323
- OMA:   IVEFGEF
- ProtClustDB:   PRK09468
- BioCyc:   ECOL83334:ECS4247-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 27354; Mature: 27354

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPG
CCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCHHEEEEEEECCC
EDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVL
CHHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHH
RRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPL
HHHHHHCCCCCCCCCEEEEEEEEEEECCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCC
SRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPG
CCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCHHEEEEEEECCC
EDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVL
CHHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHH
RRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPL
HHHHHHCCCCCCCCCEEEEEEEEEEECCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCC
SRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796