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The map label for this gene is envZ [H]

Identifier: 218691681

GI number: 218691681

Start: 3966602

End: 3967954

Strand: Reverse

Name: envZ [H]

Synonym: ECED1_4064

Alternate gene names: 218691681

Gene position: 3967954-3966602 (Counterclockwise)

Preceding gene: 218691682

Following gene: 218691679

Centisome position: 76.17

GC content: 56.91

Gene sequence:

>1353_bases
ATGAGGCGATTGCGCTTCTCGCCACGAAGTTCATTTGCCCGTACGTTATTGCTCATCGTCACCTTGCTGTTCGTCAGCCT
GGTGACGACTTATCTGGTGGTGCTGAACTTCGCGATTTTGCCGAGCCTCCAGCAGTTTAATAAAGTCCTCGCGTACGAAG
TGCGTATGTTGATGACCGACAAACTGCAACTGGAGGACGGCACGCAGTTGGTTGTGCCTCCCGCTTTCCGTCGGGAGATC
TACCGTGAGCTGGGGATCTCTCTCTATTCCAACGAAGCTGCCGAAGAGGCAGGTCTGCGTTGGGCGCAACACTATGAATT
CTTAAGCCATCAGATGGCGCAGCAACTGGGCGGTCCGACGGAAGTTCGCGTCGAGGTCAACAAAAGTTCGCCTGTCGTCT
GGCTGAAAACCTGGTTGTCGCCCAATATCTGGGTACGCGTGCCGCTAACCGAAATTCATCAGGGCGATTTCTCCCCGCTG
TTCCGTTATACGTTGGCGATTATGCTATTGGCGATAGGCGGGGCGTGGCTGTTTATTCGTATCCAGAACCGACCGTTGGT
CGATCTCGAACACGCAGCCTTGCAGGTGGGTAAAGGGATTATTCCGCCGCCGCTGCGTGAATATGGCGCTTCGGAGGTGC
GTTCCGTTACCCGCGCCTTTAATCATATGGCGGCTGGTGTTAAGCAACTGGCGGATGACCGCACGCTGCTGATGGCGGGG
GTAAGCCATGATCTGCGCACGCCGCTGACGCGTATTCGCCTGGCAACCGAGATGATGAGCGAGCAGGATGGCTACCTGGC
AGAATCGATCAATAAAGATATCGAAGAGTGCAACGCCATCATTGAGCAGTTTATCGACTACCTGCGCACCGGGCAGGAGA
TGCCGATGGAAATGGCGGATCTCAACGCCGTGCTCGGTGAGGTGATTGCCGCCGAAAGTGGCTATGAGCGGGAAATTGAA
ACCGCGCTTTACCCCGGCAGCATTGAGGTGAAAATGCACCCGCTGTCGATCAAACGCGCGGTGGCGAATATGGTGGTCAA
CGCCGCCCGTTACGGCAATGGCTGGATCAAAGTCAGCAGCGGCACGGAGCCGAATCGCGCCTGGTTCCAGGTAGAAGATG
ACGGTCCGGGTATTGCGCCGGAACAACGTAAGCACCTGTTCCAGCCGTTTGTTCGTGGCGACAGTGCGCGCACTATTAGC
GGCACGGGATTAGGGCTGGCGATTGTGCAGCGTATCGTGGATAACCATAACGGGATGCTGGAGCTTGGCACCAGCGAACG
GGGCGGGCTTTCCATTCGCGCCTGGCTGCCAGTGCCGGTAACGCGGGCGCAGGGTGCGACAAAAGAAGGGTAA

Upstream 100 bases:

>100_bases
CGCGTCTGCGCCGCATGGTGGAAGAAGATCCGGCGCATCCGCGTTACATTCAGACCGTCTGGGGTCTGGGCTACGTCTTT
GTACCGGACGGTTCTAAAGC

Downstream 100 bases:

>100_bases
ATAAAACGGGAGGCGAAGGTGCCTCCCGTTTTGCTTTCTATAAGATACTGGATAGATATTCTCCAGCTTCAAATCATTAC
AGCTTCGGACCAGCCGCTAC

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIE
TALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTIS
GTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGATKEG

Sequences:

>Translated_450_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIE
TALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTIS
GTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGATKEG
>Mature_450_residues
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIE
TALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTIS
GTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGATKEG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=450, Percent_Identity=99.5555555555556, Blast_Score=917, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=277, Percent_Identity=32.4909747292419, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=30.2919708029197, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=26.605504587156, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=270, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=31.3084112149533, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=27.5618374558304, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=27.5229357798165, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=27.9352226720648, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789403, Length=248, Percent_Identity=27.0161290322581, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=210, Percent_Identity=30.952380952381, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=279, Percent_Identity=26.1648745519713, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=23.5059760956175, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787374, Length=232, Percent_Identity=26.2931034482759, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=217, Percent_Identity=27.6497695852535, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50333; Mature: 50333

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
KLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCCCHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECC
GTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGML
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCEE
ELGTSERGGLSIRAWLPVPVTRAQGATKEG
EECCCCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
KLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCCCHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECC
GTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGML
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCEE
ELGTSERGGLSIRAWLPVPVTRAQGATKEG
EECCCCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]