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The map label for this gene is yeiQ [H]

Identifier: 218690322

GI number: 218690322

Start: 2548815

End: 2550281

Strand: Direct

Name: yeiQ [H]

Synonym: ECED1_2622

Alternate gene names: 218690322

Gene position: 2548815-2550281 (Clockwise)

Preceding gene: 218690321

Following gene: 218690323

Centisome position: 48.93

GC content: 51.6

Gene sequence:

>1467_bases
ATGAATACAATCGCCTCCGTTACGCTCCCGCATCATGTACACGCTCCACGCTACGATCGACAGCAGTTGCAATCACGTAT
CGTTCATTTTGGCTTTGGAGCCTTTCACCGCGCACATCAGGCATTACTGACCGATCGTGTGCTGAATGCCCAGGGCGGCG
ACTGGGGGATCTGTGAAATCAGCTTGTTCAGCGGCGATCAACTGATGAGCCAACTCCGCGCACAGAACCATTTATATACC
GTGCTGGAGAAAGGTGCGGACGGCAATCAGGCGATAATTGTCGGTGCCGTTCACGAATGTCTGAATGCAAAACTGGATTC
CTTAGCGGCAATTATTGAGAAATTTTGCGAGCCACAGGTGGCAATTGTTTCCCTGACGATTACCGAAAAAGGCTATTGTA
TTGACCCGGCCACCGGTGCACTCGACACCAGCAATCCGCGTATTATTCACGATCTACAAAACCCTGAAGAACCTCACTCC
GCGCCAGGTATTCTCGTCGAAGCACTGAAACGCCGCCGTGAGCGCGGCCTTACACCGTTTACCGTGCTCTCCTGCGACAA
TATTCCCGACAATGGCCATGTGGTGAAAAACGCGGTGCTGGGAATGGCAGAAAAACGTTCGCCAGAACTCGCCGGGTGGA
TAAAAGAACACGTCAGTTTTCCGGGAACTATGGTCGACCGCATTGTTCCGGCTGCAACAAACGAATCACTGGCGGAAATC
AGCCAGCATCTGGGGGTGAATGATCCCTGCGCGATTAGCTGCGAACCGTTTATCCAGTGGGTGGTTGAAGATAACTTCGT
CGCTGGGCGTCCTGCCTGGGAAGTCGCAGGTGTACAAATGGTGAATGATGTCCTGCCATGGGAAGAGATGAAACTGCGGA
TGCTTAATGGCAGCCACTCTTTTCTCGCTTATCTGGGTTACCTCTCAGGATTCGCCCATATCAGTGATTGCATGCAGGAT
CGCGCATTTCGCCATGCTGCCAGAACATTAATGCTGGATGAGCAAGCGCCGACACTGCGGATTAAAGATGTCGATTTAAC
ACAATATGCGGATAAGTTAATTGCACGTTTTGCTAATCCGGCACTGAAACATAAGACCTGGCAAATCGCGATGGATGGCA
GCCAGAAATTACCGCAACGCATGTTGGCAGGTATTCGCATACATCTGGGGCGCGAAACGGACTGGTCGTTGCTGGCATTA
GGCGTTGCAGGCTGGATGCGTTACGTCAGCGGCGTTGATGATGCCGGAAATGCCATTGATGTTCGCGATCCGCTTAGCGA
TAAAATTCGTGAACTTGTTGCGGTCAGCAGCAGTGAACAACGCGTAACCGCCCTGCTTTCCCTGCGTGAAATTTTCGGTG
ATGATCTGCCAGATAACCCGCATTTTGTGCAGGCCATCGAACAAGCCTGGCAACAAATCGCACAATTCGGCGCGCATCAG
GCGCTATTAAACACCCTCAAAATTTAA

Upstream 100 bases:

>100_bases
CCTCACACTTCATCGCATTAACAATCCAGACCAATTTCAATTGCTGTCATATAACTTTACACTGTCATTGTTAATTAATC
GTTACTAAGACGTGACTCCT

Downstream 100 bases:

>100_bases
CGATTTCTGCGGTTAAAGCGGATGAAGCTCGCCTTCGTCCGCTCTCCCCTTCTCTTTTCTGCCTTTTTTAGCCAGGATTA
ACGCTCAGTTAACTTACCAG

Product: putative sugar dehydrogenase, NAD-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYT
VLEKGADGNQAIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQNPEEPHS
APGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATNESLAEI
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQD
RAFRHAARTLMLDEQAPTLRIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHLGRETDWSLLAL
GVAGWMRYVSGVDDAGNAIDVRDPLSDKIRELVAVSSSEQRVTALLSLREIFGDDLPDNPHFVQAIEQAWQQIAQFGAHQ
ALLNTLKI

Sequences:

>Translated_488_residues
MNTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYT
VLEKGADGNQAIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQNPEEPHS
APGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATNESLAEI
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQD
RAFRHAARTLMLDEQAPTLRIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHLGRETDWSLLAL
GVAGWMRYVSGVDDAGNAIDVRDPLSDKIRELVAVSSSEQRVTALLSLREIFGDDLPDNPHFVQAIEQAWQQIAQFGAHQ
ALLNTLKI
>Mature_488_residues
MNTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYT
VLEKGADGNQAIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQNPEEPHS
APGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATNESLAEI
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQD
RAFRHAARTLMLDEQAPTLRIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHLGRETDWSLLAL
GVAGWMRYVSGVDDAGNAIDVRDPLSDKIRELVAVSSSEQRVTALLSLREIFGDDLPDNPHFVQAIEQAWQQIAQFGAHQ
ALLNTLKI

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=488, Percent_Identity=98.155737704918, Blast_Score=993, Evalue=0.0,
Organism=Escherichia coli, GI1790779, Length=485, Percent_Identity=56.701030927835, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1787823, Length=464, Percent_Identity=55.6034482758621, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1790028, Length=232, Percent_Identity=28.8793103448276, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994885, Length=481, Percent_Identity=22.4532224532225, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324401, Length=476, Percent_Identity=39.4957983193277, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320765, Length=476, Percent_Identity=39.4957983193277, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54029; Mature: 54029

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEI
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SLFSGDQLMSQLRAQNHLYTVLEKGADGNQAIIVGAVHECLNAKLDSLAAIIEKFCEPQV
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCE
AIVSLTITEKGYCIDPATGALDTSNPRIIHDLQNPEEPHSAPGILVEALKRRRERGLTPF
EEEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATNESLAEI
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHH
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHS
HHHCCCCCCCEECHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHH
FLAYLGYLSGFAHISDCMQDRAFRHAARTLMLDEQAPTLRIKDVDLTQYADKLIARFANP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHHHHCCH
ALKHKTWQIAMDGSQKLPQRMLAGIRIHLGRETDWSLLALGVAGWMRYVSGVDDAGNAID
HHHCCEEEEEECCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE
VRDPLSDKIRELVAVSSSEQRVTALLSLREIFGDDLPDNPHFVQAIEQAWQQIAQFGAHQ
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLNTLKI
HHHHHHCC
>Mature Secondary Structure
MNTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEI
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SLFSGDQLMSQLRAQNHLYTVLEKGADGNQAIIVGAVHECLNAKLDSLAAIIEKFCEPQV
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCE
AIVSLTITEKGYCIDPATGALDTSNPRIIHDLQNPEEPHSAPGILVEALKRRRERGLTPF
EEEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATNESLAEI
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHH
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHS
HHHCCCCCCCEECHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHH
FLAYLGYLSGFAHISDCMQDRAFRHAARTLMLDEQAPTLRIKDVDLTQYADKLIARFANP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHHHHCCH
ALKHKTWQIAMDGSQKLPQRMLAGIRIHLGRETDWSLLALGVAGWMRYVSGVDDAGNAID
HHHCCEEEEEECCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE
VRDPLSDKIRELVAVSSSEQRVTALLSLREIFGDDLPDNPHFVQAIEQAWQQIAQFGAHQ
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLNTLKI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]