Click here to switch to the map view.

The map label for this gene is hokE

Identifier: 218688408

GI number: 218688408

Start: 597979

End: 598131

Strand: Direct

Name: hokE

Synonym: ECED1_0575

Alternate gene names: 218688408

Gene position: 597979-598131 (Clockwise)

Preceding gene: 218688402

Following gene: 218688410

Centisome position: 11.48

GC content: 46.41

Gene sequence:

>153_bases
ATGCTGACGAAATATGCCCTTGTGGCAGTCATAGTGCTGTGTTTAACGGTGCTGGGATTTACGCTTCTGGTCGGAGACTC
GCTGTGTGAGTTTACCGTAAAGGAACGTAATATTGAGTTTAAGGCTGTTCTCGCTTACGAACCGAAGAAGTAG

Upstream 100 bases:

>100_bases
ATGAAGCCCCAGGACGATATTTCTATCAACCCTGGGGCTACCTACCCAAACCTGAACAATTTGGATGGTAGTCCCTTCTT
CGCATGGAGGCAATATAAAC

Downstream 100 bases:

>100_bases
CCGTTGTGCGGGGAGCAATCCCCGCATATCCGGTTGTCAGGTCAGGGTGGTAAGGCACCTGCTTTACACTTTCGCCCGCG
GTCAGTGATGGCTGCGGGCG

Product: toxic polypeptide, small

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 50; Mature: 50

Protein sequence:

>50_residues
MLTKYALVAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK

Sequences:

>Translated_50_residues
MLTKYALVAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK
>Mature_50_residues
MLTKYALVAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hok/gef family

Homologues:

Organism=Escherichia coli, GI48994879, Length=50, Percent_Identity=98, Blast_Score=98, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HOKE_ECO57 (Q8XBW9)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   E90706
- PIR:   H85556
- RefSeq:   NP_286308.1
- RefSeq:   NP_308648.1
- EnsemblBacteria:   EBESCT00000027145
- EnsemblBacteria:   EBESCT00000056058
- GeneID:   916980
- GeneID:   957587
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0722
- KEGG:   ecs:ECs0621
- GeneTree:   EBGT00050000009510
- HOGENOM:   HBG473224
- ProtClustDB:   CLSK879702
- BioCyc:   ECOL83334:ECS0621-MONOMER
- InterPro:   IPR000021
- InterPro:   IPR018084
- PRINTS:   PR00281
- ProDom:   PD005979

Pfam domain/function: PF01848 HOK_GEF

EC number: NA

Molecular weight: Translated: 5592; Mature: 5592

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00556 HOK_GEF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1eb741b4)-;

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKYALVAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEECCCH
>Mature Secondary Structure
MLTKYALVAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEECCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796