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The map label for this gene is pheP [H]

Identifier: 218688402

GI number: 218688402

Start: 591983

End: 593401

Strand: Direct

Name: pheP [H]

Synonym: ECED1_0568

Alternate gene names: 218688402

Gene position: 591983-593401 (Clockwise)

Preceding gene: 218688401

Following gene: 218688408

Centisome position: 11.36

GC content: 52.71

Gene sequence:

>1419_bases
GTGCCCCTCAACAAAAAAGACACACAGGGGAAAGGCGTGAAAAACGCGTCAACCGTATCGGAAGATACTGCGTCGAATCA
AGAGTCGACGCTTCATCGCGGATTACATAACCGTCATATTCAACTGATTGCGCTGGGTGGCGCAATTGGTACTGGTCTGT
TTCTTGGCATTGGTCCGGCGATTCAGATGGCGGGTCCGGCTGTATTGCTGGGCTACGGCGTCGCCGGGAGCATCGCTTTC
CTGATTATGCGCCAGCTCGGCGAGATGGTGGTCGAAGAGCCGGTATCCGGTTCATTTGCCCACTTTGCCTATAAATACTG
GGGACCGTTTGCGGGCTTCCTCTCTGGCTGGAACTACTGGGTAATGTTCGTGCTGGTGGGAATGGCAGAGCTGACCGCTG
CGGGCATCTATATGCAGTACTGGTTCCCGGATGTTCCAACGTGGATTTGGGCTGCCGCCTTCTTTATTATCATCAACGCC
GTTAACCTGGTGAACGTGCGCTTATATGGCGAAACCGAGTTCTGGTTTGCGCTGATTAAAGTGCTGGCGATCATCGGTAT
GATCGGCTTTGGCCTGTGTCTGCTGTTTTCTGGGCACGGCGGTGAGAAAGCCAGTATCGATAACCTCTGGCGCTACGGCG
GTTTCTTTGCCACCGGCTGGAATGGATTGATTTTGTCGCTGGCGGTAATTATGTTCTCCTTCGGCGGTCTGGAGCTGATT
GGGATTACTGCGGCTGAAGCGCGCGATCCGGAAAAAAGCATCCCTAAAGCAGTGAATCAGGTGGTGTATCGCATCCTGCT
GTTTTATATCGGTTCACTGGTGGTTTTACTGGCGCTCTACCCGTGGGTGGAAGTGAAATCCAATAGTAGCCCGTTTGTGA
TGATTTTCCATAATCTCGACAGCAACGTGGTGGCTTCTGCGCTGAACTTCGTCATTCTGGTGGCATCGCTGTCGGTGTAT
AACAGCGGGGTTTACTCTAACAGCCGCATGCTGTTTGGCCTTTCTGTGCAGGGTAATGCGCCAAAGTTTTTGACTCGCGT
CAGCCGTCGCGGCGTGCCGATTAACTCGCTGATGCTTTCCGGAGCGATCACTTCGCTGGTGGTGTTAATCAACTATCTGC
TGCCGCAAAAAGCGTTTGGTCTGCTGATGGCGCTGGTGGTAGCAACGCTGCTGTTGAACTGGATTATGATCTGCCTGGCG
CATCTGCGTTTTCGCGCGGCGATGCGACGTCAGGGGCGTGAAACACAATTTAAGGCGCTGCTCTATCCGTTCGGCAACTA
TCTTTGCATCGCCTTCCTCGGCATGATTTTGCTGCTGATGTGCACGATGGATGATATGCGCTTGTCAGCGATTCTGCTGC
CGGTGTGGATTGTATTCCTGTTTGTGGCGTTTAAAACATTGCGTAGGAAAGTGAACTAA

Upstream 100 bases:

>100_bases
TGATGTGGCTGCACCGACATCGGGTACGGAAATAAAAGCAGGATACCCCGTTTAACCGTGTGGATTGTGTCTTGCGACGA
TGGGCACTAAATGTTAAAAG

Downstream 100 bases:

>100_bases
GCTGATGTGAGGCTGATTTGCCCGATGCGCAAGCTTATCGGGCCTACAATTTGTAACGATTCTGTAGGTCGGATAAGGCG
TTCACGCCGCATCCGACAAA

Product: phenylalanine transporter

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MPLNKKDTQGKGVKNASTVSEDTASNQESTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGSIAF
LIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINA
VNLVNVRLYGETEFWFALIKVLAIIGMIGFGLCLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVY
NSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLA
HLRFRAAMRRQGRETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRKVN

Sequences:

>Translated_472_residues
MPLNKKDTQGKGVKNASTVSEDTASNQESTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGSIAF
LIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINA
VNLVNVRLYGETEFWFALIKVLAIIGMIGFGLCLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVY
NSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLA
HLRFRAAMRRQGRETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRKVN
>Mature_471_residues
PLNKKDTQGKGVKNASTVSEDTASNQESTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGSIAFL
IMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAV
NLVNVRLYGETEFWFALIKVLAIIGMIGFGLCLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIG
ITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVYN
SGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAH
LRFRAAMRRQGRETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRKVN

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=290, Percent_Identity=27.2413793103448, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=405, Percent_Identity=24.1975308641975, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI258645169, Length=439, Percent_Identity=21.1845102505695, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI115648063, Length=457, Percent_Identity=21.8818380743982, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=457, Percent_Identity=21.8818380743982, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786789, Length=458, Percent_Identity=98.9082969432314, Blast_Score=905, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=440, Percent_Identity=62.9545454545455, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=43.8228438228438, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=44.6902654867257, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1790653, Length=453, Percent_Identity=38.1898454746137, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI87081915, Length=430, Percent_Identity=36.046511627907, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.8909512761021, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87081708, Length=447, Percent_Identity=35.1230425055928, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788480, Length=418, Percent_Identity=37.5598086124402, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI87081869, Length=174, Percent_Identity=28.1609195402299, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082023, Length=404, Percent_Identity=23.2673267326733, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=392, Percent_Identity=23.7244897959184, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=392, Percent_Identity=22.7040816326531, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=36.4253393665158, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6324061, Length=457, Percent_Identity=35.0109409190372, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6324059, Length=460, Percent_Identity=34.5652173913044, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319824, Length=458, Percent_Identity=31.4410480349345, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=436, Percent_Identity=34.8623853211009, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6321629, Length=437, Percent_Identity=31.350114416476, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6324990, Length=441, Percent_Identity=32.4263038548753, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6324924, Length=475, Percent_Identity=29.8947368421053, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=34.0050377833753, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320717, Length=503, Percent_Identity=28.2306163021869, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321053, Length=451, Percent_Identity=31.0421286031042, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319543, Length=436, Percent_Identity=31.8807339449541, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6320251, Length=488, Percent_Identity=28.4836065573771, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=31.3924050632911, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319542, Length=487, Percent_Identity=26.694045174538, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324981, Length=416, Percent_Identity=32.6923076923077, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=416, Percent_Identity=29.5673076923077, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320364, Length=487, Percent_Identity=27.7207392197125, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24666159, Length=422, Percent_Identity=22.7488151658768, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI221512776, Length=422, Percent_Identity=22.7488151658768, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52007; Mature: 51875

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNKKDTQGKGVKNASTVSEDTASNQESTLHRGLHNRHIQLIALGGAIGTGLFLGIGPA
CCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCHH
IQMAGPAVLLGYGVAGSIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYW
HHHCCCHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
VMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIK
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHH
VLAIIGMIGFGLCLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCEEEE
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLD
EEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCC
SNVVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHH
GAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRKVN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLNKKDTQGKGVKNASTVSEDTASNQESTLHRGLHNRHIQLIALGGAIGTGLFLGIGPA
CCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCHH
IQMAGPAVLLGYGVAGSIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYW
HHHCCCHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
VMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIK
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHH
VLAIIGMIGFGLCLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCEEEE
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLD
EEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCC
SNVVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHH
GAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRKVN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]