Click here to switch to the map view.

The map label for this gene is ppiD

Identifier: 218688305

GI number: 218688305

Start: 482637

End: 484508

Strand: Direct

Name: ppiD

Synonym: ECED1_0465

Alternate gene names: 218688305

Gene position: 482637-484508 (Clockwise)

Preceding gene: 218688304

Following gene: 218688306

Centisome position: 9.26

GC content: 52.08

Gene sequence:

>1872_bases
ATGATGGACAGCTTACGCACGGCTGCAAACAGTCTCGTGCTCAAGATTATTTTCGGTATCATTATCGTGTCGTTCATATT
GACCGGCGTGAGTGGTTACCTGATTGGCGGAGGCAATAACTACGCCGCAAAAGTGAATGACCAGGAAATCAGCCGTGGGC
AATTCGAGAACGCCTTCAACAGCGAGCGTAATCGCATGCAGCAACAGCTGGGCGATCAATACTCCGAGCTGGCAGCGAAC
GAAGGCTATATGAAAACCCTGCGTCAACAGGTGCTGAATCGTCTGATCGACGAGGCGCTTCTGGATCAGTACGCTCGTGA
GCTGAAACTGGGTATCAGCGATGAGCAGGTTAAACAGGCGATTTTCGCGACCCCAGCCTTCCAGGTTGATGGCAAATTTG
ATAACAGCCGCTATAACGGTATCCTCAACCAGATGGGGATGACCGCCGATCAGTACGCCCAGGCGCTGCGTAACCAGCTC
ACTACCCAACAGCTGATTAACGGCGTTGCCGGTACCGATTTTATGCTGAAAGGTGAAACCGACGAGCTGGCGGCACTGGT
AGCTCAACAACGCGTGGTGCGTGAAGCGACTATCGATGTTAACGCGCTGGCGGCGAAGCAGCCTGTGACCGAACAGGAAA
TTGCCAGCTACTACGAACAAAACAAAAACAATTTCATGACGCCGGAACAATTCCGCGTGAGTTACATCAAGCTGGATGCC
GCGACGATGCAGCAACCGGTTAGCGATGCGGATATCCAGAGCTACTACGATCAGCATCAGGATCAATTCACCCAGCCGCA
GCGTACCCGTTACAGCATCATCCAGACCAAAACTGAAGATGAAGCGAAAGCGGTACTTGATGAGCTGAATAAGGGCGGTG
ATTTTGCTGCATTAGCCAAAGAAAAATCTGCCGATATTATCTCTGCCCGCAACGGCGGTGATATGGGTTGGTTAGAAGAT
GCCACTATCCCGGACGAACTGAAAAATGCGGGTCTGAAAGAAAAAGGCCAACTGTCTGGTGTTATCAAATCTTCGGTCGG
TTTCCTGATTGTGCGTCTGGACGACATTCAGCCAGCGAAAGTGAAATCGTTAGACGAAGTACGTGACGACATTGCGGCGA
AAGTGAAACACGAAAAAGCCCTCGATGCGTACTACGCGCTGCAGCAGAAAGTGAGCGATGCGGCAAGCAACGACACCGAG
TCTCTGGCCGGTGCAGAGCAAGCTGCCGGCGTTAAAGCCACTCAGACGGGTTGGTTCAGCAAAGATAACCTGCCGGAAGA
GTTGAACTTCAAGCCAGTTGCCGACGCTATCTTCAACGGCGGTCTGGTAGGTGAAAACGGCGCGCCGGGCATCAACTCTG
ACATCATCACCGTAGACGGCGACCGCGCATTCGTGCTGCGCATCAGCGAGCACAAACCGGAAGCGGTGAAACCGTTGGCA
GATGTTCAGGAACAAGTTAAGGCACTGGTTCAGCACAACAAAGCTGAACAACAGGCGAAAGTGGATGCTGAGAAACTGCT
GGTTGATTTGAAAGCAGGCAAAGGTGCGGAAGCTATGCAGGCTGCCGGTCTGAAATTTGGCGAGCCGAAAACCTTAAGTC
GTTCCGGTCGTGACCCGATTAGCCAGGCTGCGTTTGCACTGCCGCTGCCAGCGAAAGACAAACCGAGCTACGGTATGGCG
ACCGATATGCAAGGTAATGTAGTTCTGCTGGCGCTGGATGAAGTGAAGCAAGGTTCAATGCCGGAAGATCAGAAAAAAGC
GATGGTGCAGGGTATCACCCAGAACAACGCACAAATCGTCTTTGAAGCTCTGATGAGTAACCTGCGTAAAGAGGCGAAAA
TCAAAATTGGCGATGCGCTGGAACAGCAATAA

Upstream 100 bases:

>100_bases
GGGCTGACAATTGCCCCCGTTTCTTGTCACAATAGGCCTTTGCGCGCATCGATACGTTGCGTGAGGTACACAGTCATCTA
CAGCGGAGTGTTGTTACACC

Downstream 100 bases:

>100_bases
TCCTGAAGCCGCCTCGCAAAAAAATGCTTTGCAGCTGTAACAAGAAAAGGTCGCTTTCGCGGCCTTTTCCATTTCTGAAC
ATTGCCATTTGTTTACTGTT

Product: peptidyl-prolyl cis-trans isomerase D

Products: NA

Alternate protein names: PPIase D; Rotamase D

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQEISRGQFENAFNSERNRMQQQLGDQYSELAAN
EGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQL
TTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLED
ATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTE
SLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMA
TDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ

Sequences:

>Translated_623_residues
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQEISRGQFENAFNSERNRMQQQLGDQYSELAAN
EGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQL
TTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLED
ATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTE
SLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMA
TDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ
>Mature_623_residues
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQEISRGQFENAFNSERNRMQQQLGDQYSELAAN
EGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQL
TTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLED
ATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTE
SLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMA
TDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

Organism=Escherichia coli, GI1786645, Length=623, Percent_Identity=100, Blast_Score=1262, Evalue=0.0,
Organism=Escherichia coli, GI1786238, Length=273, Percent_Identity=27.1062271062271, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPID_ECOL6 (P0ADY2)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_752491.1
- ProteinModelPortal:   P0ADY2
- SMR:   P0ADY2
- EnsemblBacteria:   EBESCT00000043253
- GeneID:   1040432
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c0557
- GeneTree:   EBGT00050000010849
- HOGENOM:   HBG731256
- OMA:   TPEFQVD
- ProtClustDB:   PRK10788
- BRENDA:   5.2.1.8
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 68151; Mature: 68151

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ec0b7d4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQEISRGQFENAFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHHHHHHHHHHHH
SERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQLTTQQLINGVAGTDFMLKGET
HHCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCH
DELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHEEEEEEECH
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAK
HHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHH
EKSADIISARNGGDMGWLEDATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAK
HCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCHH
VKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGAEQAAGVKATQTGWFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHCCCCCCCCCCCC
KDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
CCCCCCCCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHH
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCH
SQAAFALPLPAKDKPSYGMATDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIV
HHHHEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHH
FEALMSNLRKEAKIKIGDALEQQ
HHHHHHHHHHHHEEEECHHHCCH
>Mature Secondary Structure
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQEISRGQFENAFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHHHHHHHHHHHH
SERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQLTTQQLINGVAGTDFMLKGET
HHCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCH
DELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHEEEEEEECH
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAK
HHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHH
EKSADIISARNGGDMGWLEDATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAK
HCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCHH
VKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGAEQAAGVKATQTGWFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHCCCCCCCCCCCC
KDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
CCCCCCCCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHH
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCH
SQAAFALPLPAKDKPSYGMATDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIV
HHHHEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHH
FEALMSNLRKEAKIKIGDALEQQ
HHHHHHHHHHHHEEEECHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157