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The map label for this gene is nrdR

Identifier: 218688276

GI number: 218688276

Start: 453849

End: 454298

Strand: Direct

Name: nrdR

Synonym: ECED1_0436

Alternate gene names: 218688276

Gene position: 453849-454298 (Clockwise)

Preceding gene: 218688273

Following gene: 218688277

Centisome position: 8.71

GC content: 51.11

Gene sequence:

>450_bases
ATGCATTGCCCATTCTGTTTCGCCGTGGACACTAAGGTAATTGACTCTCGTCTCGTGGGCGAGGGTTCATCCGTACGCCG
CCGTCGGCAGTGTCTGGTGTGTAATGAACGTTTCACCACCTTTGAAGTGGCGGAGCTGGTTATGCCGCGTGTTGTAAAAA
GCAACGACGTGCGTGAACCGTTTAATGAAGAGAAATTACGTAGCGGAATGCTGCGGGCGCTGGAAAAACGTCCGGTGAGT
TCCGATGACGTCGAAATGGCAATCAATCATATAAAATCGCAGCTGCGCGCCACCGGTGAGCGCGAAGTGCCGAGCAAGAT
GATTGGCAATCTGGTGATGGAGCAATTGAAAAAGCTCGATAAAGTCGCCTATATCCGTTTTGCCTCTGTCTACCGCAGTT
TCGAAGATATCAAAGAATTTGGCGAAGAGATCGCGCGCCTGGAGGACTAA

Upstream 100 bases:

>100_bases
GTGAAAGCATCGATCCTTTATCTCAAAAGCGTTGCGCCTTTGTTGTATCGTCAGTTCAGGGTAAAATAGATTTCTGTTAA
CCACCTGGTCAGGACGCCGT

Downstream 100 bases:

>100_bases
GCCGTGCAGGACGAGTATTACATGGCGCGGGCGCTAAAGCTGGCGCAACGAGGACGTTTTACCACGCATCCCAACCCGAA
TGTCGGGTGCGTCATTGTCA

Product: transcriptional regulator NrdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVS
SDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED

Sequences:

>Translated_149_residues
MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVS
SDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED
>Mature_149_residues
MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVS
SDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=149, Percent_Identity=100, Blast_Score=303, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_ECO24 (A7ZIG6)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001461595.1
- ProteinModelPortal:   A7ZIG6
- STRING:   A7ZIG6
- EnsemblBacteria:   EBESCT00000022029
- GeneID:   5588868
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_0444
- eggNOG:   COG1327
- GeneTree:   EBGT00050000009026
- HOGENOM:   HBG351755
- OMA:   FASVYRD
- ProtClustDB:   PRK00464
- BioCyc:   ECOL331111:ECE24377A_0444-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 17229; Mature: 17229

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREP
CCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
FNEEKLRSGMLRALEKRPVSSDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KVAYIRFASVYRSFEDIKEFGEEIARLED
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREP
CCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
FNEEKLRSGMLRALEKRPVSSDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KVAYIRFASVYRSFEDIKEFGEEIARLED
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA