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The map label for this gene is secD

Identifier: 218688271

GI number: 218688271

Start: 448632

End: 450479

Strand: Direct

Name: secD

Synonym: ECED1_0431

Alternate gene names: 218688271

Gene position: 448632-450479 (Clockwise)

Preceding gene: 218688270

Following gene: 218688272

Centisome position: 8.61

GC content: 53.35

Gene sequence:

>1848_bases
GTGTTAAACCGTTATCCTTTGTGGAAGTACGTCATGCTGATCGTGGTGATTGTCATCGGTCTGCTGTATGCGCTTCCCAA
CCTGTTTGGTGAGGATCCGGCTGTTCAGATCACTGGTGCGCGCGGAGTCGCCGCCAGTGAGCAAACGCTGATCCAGGTCC
AGAAAACGTTACAAGAAGAAAAAATAACTGCTAAGTCTGTGGCACTGGAAGAGGGCGCTATTCTTGCGCGCTTCGACTCC
ACTGACACCCAGCTGCGCGCTCGTGAAGCATTAATGGGCGTTATGGGTGACAAATACGTCGTGGCGCTTAACCTTGCCCC
GGCAACGCCGCGCTGGCTGGCAGCTATTCATGCTGAGCCGATGAAGCTCGGCCTTGACCTGCGTGGCGGCGTTCACTTCC
TGATGGAAGTGGATATGGACACCGCGCTTGGCAAACTCCAGGAACAAAATATCGATAGCCTGCGCAGCGACCTGCGTGAA
AAGGGCATCCCGTATACCACCGTTCGTAAAGAAAACAACTACGGCCTGAGCATCACTTTCCGCGATGCTAAAGCTCGTGA
TGAAGCCATTGCGTATCTGAGCAAGCGCCATCCGGACCTGGTGATTAGCAGCCAGGGCAGCAACCAGCTGCGTGCGGTAA
TGAGCGATGCTCGTCTGAGTGAAGCGCGTGAATATGCGGTGCAGCAGAACATCAATATCCTGCGTAACCGTGTAAACCAA
CTTGGCGTGGCGGAGCCGGTGGTTCAGCGTCAGGGTGCTGACCGTATCGTTGTTGAACTGCCAGGTATTCAGGACACTGC
GCGTGCGAAAGAGATTCTGGGTGCGACGGCAACGCTGGAATTCCGTCTGGTAAACACCAACGTTGATCAGGCCGCTGCGG
CATCCGGTCGCGTACCGGGCGACTCTGAAGTGAAACAGACCCGCGAAGGTCAGCCGGTTGTGCTGTACAAACGCGTAATT
CTGACCGGTGACCATATCACCGACTCCACTTCCAGCCAGGACGAATACAACCAGCCCCAGGTTAACATCTCGCTCGATAG
CGCGGGTGGTAACATCATGTCTAACTTCACCAAGGACAACATCGGCAAACCGATGGCAACCCTGTTTGTGGAGTACAAAG
ACAGCGGTAAGAAAGATGCAAACGGTCGTGCGGTTCTGGTGAAACAGGAAGAGGTGATTAACATCGCCAACATCCAGTCT
CGTCTGGGTAACAGCTTCCGTATCACCGGCATCAACAACCCGAACGAAGCGCGTCAGCTGTCGCTGCTGCTGCGTGCCGG
TGCGTTGATTGCACCGATTCAGATTGTTGAAGAACGTACCATTGGTCCGACCCTGGGTATGCAGAACATTGAACAGGGGC
TGGAGGCTTGCCTTGCCGGTCTGCTGGTTTCTATTCTGTTCATGATTATCTTCTATAAGAAGTTTGGTCTGATTGCGACC
AGTGCTCTGATTGCCAACTTGATCTTGATTGTCGGTATTATGTCGCTGTTGCCAGGCGCAACGCTGAGTATGCCAGGTAT
CGCGGGTATCGTCTTAACCCTTGCGGTAGCGGTCGATGCGAACGTACTGATCAACGAACGTATTAAAGAAGAGTTGAGCA
ACGGACGTACTGTTCAACAGGCAATTGATGAAGGTTATCGTGGCGCATTCAGTTCCATCTTCGATGCGAACATCACCACG
CTGATTAAAGTCATCATCCTGTATGCAGTGGGTACCGGGGCAATTAAAGGGTTCGCGATTACTACCGGTATCGGTGTGGC
GACGTCGATGTTTACCGCGATTGTCGGTACGCGTGCCATCGTAAACCTGCTATATGGCGGCAAGCGCGTCAAGAAGCTGT
CAATCTGA

Upstream 100 bases:

>100_bases
CACCACTGAAGTAGTTATTAAACGTGACTTCGTAGCTGCCGTTCTGCCGAAAGGCACCATGAAGGCGCTGTAATTAAAAT
TTTTCCCTAAGGGAATTGCC

Downstream 100 bases:

>100_bases
GGAGTGCGATGTGGCACAGGAATATACTGTTGAACAACTAAACCACGGCCGTAAAGTCTATGACTTTATGCGCTGGGACT
ACTGGGCTTTCGGCATCTCT

Product: preprotein translocase subunit SecD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEEKITAKSVALEEGAILARFDS
TDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEPMKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLRE
KGIPYTTVRKENNYGLSITFRDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQ
LGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPGDSEVKQTREGQPVVLYKRVI
LTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDNIGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQS
RLGNSFRITGINNPNEARQLSLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIAT
SALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQAIDEGYRGAFSSIFDANITT
LIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAIVNLLYGGKRVKKLSI

Sequences:

>Translated_615_residues
MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEEKITAKSVALEEGAILARFDS
TDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEPMKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLRE
KGIPYTTVRKENNYGLSITFRDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQ
LGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPGDSEVKQTREGQPVVLYKRVI
LTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDNIGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQS
RLGNSFRITGINNPNEARQLSLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIAT
SALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQAIDEGYRGAFSSIFDANITT
LIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAIVNLLYGGKRVKKLSI
>Mature_615_residues
MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEEKITAKSVALEEGAILARFDS
TDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEPMKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLRE
KGIPYTTVRKENNYGLSITFRDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQ
LGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPGDSEVKQTREGQPVVLYKRVI
LTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDNIGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQS
RLGNSFRITGINNPNEARQLSLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIAT
SALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQAIDEGYRGAFSSIFDANITT
LIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAIVNLLYGGKRVKKLSI

Specific function: Involved in protein export

COG id: COG0342

COG function: function code U; Preprotein translocase subunit SecD

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secD/secF family. SecD subfamily

Homologues:

Organism=Escherichia coli, GI1786609, Length=615, Percent_Identity=100, Blast_Score=1237, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECD_ECO57 (P0AG91)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C90686
- PIR:   G85536
- RefSeq:   NP_286147.1
- RefSeq:   NP_308486.1
- ProteinModelPortal:   P0AG91
- EnsemblBacteria:   EBESCT00000024120
- EnsemblBacteria:   EBESCT00000055399
- GeneID:   914561
- GeneID:   957363
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0507
- KEGG:   ecs:ECs0459
- GeneTree:   EBGT00050000009087
- HOGENOM:   HBG302175
- OMA:   VNLWYGR
- ProtClustDB:   PRK05812
- BioCyc:   ECOL83334:ECS0459-MONOMER
- InterPro:   IPR005791
- InterPro:   IPR022813
- InterPro:   IPR022646
- InterPro:   IPR022645
- TIGRFAMs:   TIGR00916
- TIGRFAMs:   TIGR01129

Pfam domain/function: PF07549 Sec_GG; PF02355 SecD_SecF

EC number: NA

Molecular weight: Translated: 66633; Mature: 66633

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d0ff4d4)-; HASH(0x1dcddc98)-; HASH(0x1ed9e654)-; HASH(0x1ef43b84)-; HASH(0x1f074734)-; HASH(0x1ef32844)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
KITAKSVALEEGAILARFDSTDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEP
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCH
MKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLREKGIPYTTVRKENNYGLSITF
HHCCCCCCCCEEEEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
RDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQ
CCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPG
CCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCEEEEEEEEEECCCHHHHHCCCCCCC
DSEVKQTREGQPVVLYKRVILTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDN
CHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHCCCHHC
IGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQSRLGNSFRITGINNPNEARQL
CCCCHHHEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
SLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIAT
HHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQ
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
AIDEGYRGAFSSIFDANITTLIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
VNLLYGGKRVKKLSI
HHHHHCCCCEEECCH
>Mature Secondary Structure
MLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
KITAKSVALEEGAILARFDSTDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEP
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCH
MKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLREKGIPYTTVRKENNYGLSITF
HHCCCCCCCCEEEEEEECHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
RDAKARDEAIAYLSKRHPDLVISSQGSNQLRAVMSDARLSEAREYAVQQNINILRNRVNQ
CCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVAEPVVQRQGADRIVVELPGIQDTARAKEILGATATLEFRLVNTNVDQAAAASGRVPG
CCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCEEEEEEEEEECCCHHHHHCCCCCCC
DSEVKQTREGQPVVLYKRVILTGDHITDSTSSQDEYNQPQVNISLDSAGGNIMSNFTKDN
CHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHCCCHHC
IGKPMATLFVEYKDSGKKDANGRAVLVKQEEVINIANIQSRLGNSFRITGINNPNEARQL
CCCCHHHEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
SLLLRAGALIAPIQIVEERTIGPTLGMQNIEQGLEACLAGLLVSILFMIIFYKKFGLIAT
HHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALIANLILIVGIMSLLPGATLSMPGIAGIVLTLAVAVDANVLINERIKEELSNGRTVQQ
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
AIDEGYRGAFSSIFDANITTLIKVIILYAVGTGAIKGFAITTGIGVATSMFTAIVGTRAI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
VNLLYGGKRVKKLSI
HHHHHCCCCEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796