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The map label for this gene is fkpB

Identifier: 218687902

GI number: 218687902

Start: 27048

End: 27497

Strand: Direct

Name: fkpB

Synonym: ECED1_0025

Alternate gene names: 218687902

Gene position: 27048-27497 (Clockwise)

Preceding gene: 218687901

Following gene: 218687903

Centisome position: 0.52

GC content: 54.44

Gene sequence:

>450_bases
ATGTCTGAATCTGTACAGAGCAATAGCGCCGTCCTGGTGCACTTCACGCTAAAACTCGACGATGGCACCACCGCTGAGTC
TACCCGCAACAATGGTAAACCGGCGCTGTTCCGCCTGGGTGATGCTTCTCTTTCTGAAGGGCTGGAGCAACACCTGCTGG
GGCTGAAAGTGGGCGATAAAACCACCTTCTCGCTGGAGCCAGATGCGGCGTTTGGCGTGCCGTCACCGGACCTGATTCAG
TACTTCTCCCGCCGTGAATTTATGGATGCAGGCGAGCCAGAAATTGGCGCAATCATGCTTTTTACCGCAATGGATGGCAG
TGAGATGCCTGGCGTGATCCGCGAAATTAACGGCGACTCCATTACCGTTGATTTCAACCATCCGCTGGCCGGGCAGACCG
TTCATTTTGATATTGAAGTGCTGGAAATCGATCCGGCACTGGAGGCGTAA

Upstream 100 bases:

>100_bases
TGCCGGATACGATGCTGACGCATCTTATCCGGCCTACAGATTGCTGCGAAATCGTAGGTCGCATCCGGCAAAAATCCTCA
AAATATAAGAGCAAACCTGC

Downstream 100 bases:

>100_bases
CATGCAGATCCTGTTGGCCAACCCGCGTGGTTTTTGTGCCGGGGTAGACCGCGCTATCAGCATTGTTGAAAACGCGCTGG
CCATTTACGGCGCACCGATA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVPSPDLIQ
YFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA

Sequences:

>Translated_149_residues
MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVPSPDLIQ
YFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA
>Mature_148_residues
SESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDKTTFSLEPDAAFGVPSPDLIQY
FSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDSITVDFNHPLAGQTVHFDIEVLEIDPALEA

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1786211, Length=149, Percent_Identity=100, Blast_Score=301, Evalue=1e-83,
Organism=Escherichia coli, GI1789748, Length=146, Percent_Identity=31.5068493150685, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FKBX_ECO57 (P0AEM2)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   F85483
- PIR:   G90632
- RefSeq:   NP_285722.1
- RefSeq:   NP_308058.1
- ProteinModelPortal:   P0AEM2
- SMR:   P0AEM2
- EnsemblBacteria:   EBESCT00000024101
- EnsemblBacteria:   EBESCT00000057733
- GeneID:   913427
- GeneID:   956693
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0033
- KEGG:   ecs:ECs0031
- GeneTree:   EBGT00050000009174
- HOGENOM:   HBG731200
- OMA:   TFKVGDG
- ProtClustDB:   PRK15095
- BioCyc:   ECOL83334:ECS0031-MONOMER
- InterPro:   IPR001179
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C

EC number: =5.2.1.8

Molecular weight: Translated: 16081; Mature: 15950

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDK
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHEEEECCC
TTFSLEPDAAFGVPSPDLIQYFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDS
EEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCE
ITVDFNHPLAGQTVHFDIEVLEIDPALEA
EEEEECCCCCCCEEEEEEEEEEECCCCCC
>Mature Secondary Structure 
SESVQSNSAVLVHFTLKLDDGTTAESTRNNGKPALFRLGDASLSEGLEQHLLGLKVGDK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHEEEECCC
TTFSLEPDAAFGVPSPDLIQYFSRREFMDAGEPEIGAIMLFTAMDGSEMPGVIREINGDS
EEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCE
ITVDFNHPLAGQTVHFDIEVLEIDPALEA
EEEEECCCCCCCEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796