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The map label for this gene is argD [H]

Identifier: 218550622

GI number: 218550622

Start: 3389958

End: 3391178

Strand: Reverse

Name: argD [H]

Synonym: EFER_3332

Alternate gene names: 218550622

Gene position: 3391178-3389958 (Counterclockwise)

Preceding gene: 218550623

Following gene: 218550619

Centisome position: 73.9

GC content: 54.05

Gene sequence:

>1221_bases
ATGGCAATTGAACAAACAGCAATTACACGCGCGACTTTCGATGAAGTGATCCTGCCGATTTATGCTCCGGCAGAGTTTAT
TCCGGTAAAAGGTCTGGGCAGCAGAATCTGGGATCAGCAAGGCAAGGAGTATGTCGATTTCGCGGGTGGCATTGCAGTTA
CGGCGTTGGGCCATTGCCATCCTGCGCTGGTGAACGCGTTAAAAACCCAGGGCGAAACTCTGTGGCATATCAGTAACGTT
TTTACCAATGAACCGGCGCTGCGTCTTGGTCGTAAACTGATTGAGGCAACGTTTGCCGAACGCGTGGTGTTTATGAACTC
CGGCACGGAAGCTAACGAAACAGCCTTTAAACTGGCACGCCATTACGCCTGTGTGCGTCATAGCCCGTTCAAAACCAAAA
TTATTGCCTTCCATAACGCTTTTCATGGTCGTTCGCTGTTTACCGTCTCGGTGGGCGGGCAGCCAAAATATTCAGACGGC
TTTGGGCCAAAACCGGCAGACATCATCCACGTTCCCTTTAATGATCTCCACGCAGTGAAAGCGGTGATGGATGATCATAC
CTGTGCGGTGGTGGTTGAGCCGATTCAGGGCGAGGGCGGCGTGACGGCTGCGACGCCAGAGTTTTTGCAGGGCTTGCGCG
AACTCTGTGATGAGCATCAGGCATTATTGGTGTTTGATGAAGTGCAGTGCGGGATGGGGCGGACCGGCGATCTGTTTGCT
TACATGCATTACGGCGTGACGCCGGATATTCTGACCTCCGCCAAAGCGTTAGGTGGCGGCTTCCCGATTAGCGCCATGCT
GACTACGGCGGAGATTGCTTCTGCGTTTCATCCTGGTTCTCACGGTTCCACCTACGGCGGTAATCCACTGGCCTGTGCAG
TAGCGGGTGCGGCGTTTGATATCATCAATACCCCTGAAGTGCTGGAAGGCATTCACGCGAAACGCCAGCGTTTTGTGGAC
CATTTGCAGAAGATCGATCAGCAGTACGATGTGTTTAGCGATATTCGCGGTATGGGGCTGTTGATTGGCGCAGAGCTGAA
ACCACAGTACAAAGGTCGGGCGCGTGATTTCCTGTATGCGGGTGCCGAGGCAGGCGTAATGGTGCTGAATGCCGGGCCTG
ATGTGATGCGTTTTGCGCCGTCGCTGGTGGTGGAAGATGCGGATATCGATGAAGGGATGCATCGTTTCGCCCACGCGGTG
GCGAAGGTGATTGGGGCGTAA

Upstream 100 bases:

>100_bases
TTCCTGGAGCGCTGATTTCTGATTGCCATTCAGTGATTTTTTATGCATATTTTGTGATTATAATTTCACGTTGAGTTATG
CGTAACAGGGTGATCATGAG

Downstream 100 bases:

>100_bases
ATAAGACGCGTCAGCGTCGCATCAGGCAAAAGATGTCGGATGCGACGTAAACGCCTTATCCGATGGTTTAGCCTGTATTA
CGCCTTCGAATCCCGCAACT

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGLGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDEHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIHAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAV
AKVIGA

Sequences:

>Translated_406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGLGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDEHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIHAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAV
AKVIGA
>Mature_405_residues
AIEQTAITRATFDEVILPIYAPAEFIPVKGLGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVF
TNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGF
GPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDEHQALLVFDEVQCGMGRTGDLFAY
MHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIHAKRQRFVDH
LQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAVA
KVIGA

Specific function: Involved in both the arginine and lysine biosynthetic pathways [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=378, Percent_Identity=37.037037037037, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI284507298, Length=294, Percent_Identity=38.7755102040816, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI13994255, Length=419, Percent_Identity=28.8782816229117, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI37574042, Length=401, Percent_Identity=30.4239401496259, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI226442709, Length=374, Percent_Identity=31.0160427807487, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=401, Percent_Identity=29.1770573566085, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI24119277, Length=393, Percent_Identity=26.7175572519084, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI188536080, Length=416, Percent_Identity=23.5576923076923, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI38679950, Length=416, Percent_Identity=23.5576923076923, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI38679946, Length=416, Percent_Identity=23.5576923076923, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=98.7684729064039, Blast_Score=827, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=60.7142857142857, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1789016, Length=395, Percent_Identity=36.4556962025316, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1787560, Length=393, Percent_Identity=34.0966921119593, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI145693181, Length=325, Percent_Identity=37.2307692307692, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=32.1766561514196, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786991, Length=299, Percent_Identity=33.4448160535117, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=36.2666666666667, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=37.3076923076923, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=28.4064665127021, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=28.0952380952381, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=25.7471264367816, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=32.3170731707317, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=397, Percent_Identity=38.2871536523929, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=32.5062034739454, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=29.2993630573248, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=24.8275862068966, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=377, Percent_Identity=34.7480106100796, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28574759, Length=421, Percent_Identity=28.0285035629454, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161085790, Length=407, Percent_Identity=28.2555282555283, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=29.6912114014252, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281366494, Length=434, Percent_Identity=22.3502304147465, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667139, Length=434, Percent_Identity=22.3502304147465, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667143, Length=434, Percent_Identity=22.3502304147465, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11; =2.6.1.17 [H]

Molecular weight: Translated: 43785; Mature: 43654

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEQTAITRATFDEVILPIYAPAEFIPVKGLGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCCHHHHHHHHHHHHHEEEECCCCEEECCCCCHHHHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDEHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIHAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAVAKVIGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIEQTAITRATFDEVILPIYAPAEFIPVKGLGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCHHHHHHHHHHHHHEEEECCCCEEECCCCCHHHHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDEHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIHAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAVAKVIGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]