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The map label for this gene is uvrD [H]

Identifier: 218550117

GI number: 218550117

Start: 2870259

End: 2872043

Strand: Direct

Name: uvrD [H]

Synonym: EFER_2805

Alternate gene names: 218550117

Gene position: 2870259-2872043 (Clockwise)

Preceding gene: 218550116

Following gene: 218550124

Centisome position: 62.55

GC content: 33.17

Gene sequence:

>1785_bases
ATGCCAAGATGGAGAGGTATAAAGATGACGCATTTTAACTCTCAACAGATGGATTATATCGAATCCTCTATTGCCTCTAG
TATTTATCTTGAGGCGTGTCCTGGTAGTGGAAAAACTGAAGTCATTGCAGCTAAAGTTGCAAAGGAGATAAATAATTGGA
CACTTAGTCCTAGTGGTATAGCTTTATTATCCTTTTCTAATAGCGCTACAGATGAACTTTTCTCACGGGTTAAAAAGTAC
TCCCCCGATACGGTCAGTAGATTCCCACACTTCATTGGAACTTTTGATAGTTTTATATTTAAGTTTTTAATTGGTCCTAA
CGCAAAATGTTTGACTCATTTTGAAGGGGAATGTAATAAAAATACTTTAAGGATTATAGAGTCTGCGTCACCATTATTCA
TTCAAACAAAATATGCTTACAATAAAAGAGGGAAGATCAAAGCACACCATTATACTTTTGATAGAAGAAATGATTCCATA
CTGTTCAACTCGGATAGCCCCGAACTTGACAGAATGAGAAACGCCATAAACCTGCAGGAATGGCAAATTAAAGATTTAAT
AGAAACAAAATATAAGTTATTTAAATCTGGATTAATGACTCACGATGACTCACTATTTCTTGCTGCTGAAATCTTCATTA
ATGAAAAGTATAAAAATTATGCTTTATTACTCTCTAAAAGATTTCCACTAATTATTATTGATGAGTGCCAAGATTTATCA
TACGAGCACTTATTTATATTACAGGGGCTTCATGATTTAGGAGTTAAACTTCACTTTGTCGGTGATTTAGAACAATCCAT
TTATGGTTTCCGTGCTGTAGATCCTAAAGATACAATAAAATTCATTACTGACAATGAATTCGAAAGAATGCCATTAAAAA
TTAATTATCGGAGCTGTCAGCAAATCATTGATCTTTGTTCAAAATTAACAGCACATGATGGTGTTAATGGCCAATTTAGT
TCAATTGAATCTCCCTGTATCGTTTTGCAGTATAATGAAACGCCTCTAGAATTAATCGATAAAATTGGACAGCTATGTTT
CGGATACAGTAATAATGTAATCGTAGCTCGTGGGCACTCTATTTTGGAAAAGTTCACATTTAATGGTGTTGAAGATAATA
TTGTGAAAAACCTTGTTAATGCAATAAATATTTTCTCATTACATGGAACTCAAAATATAAAAAACTCACTGCAGTTATTT
TCAACAGTGATACGCGCGAGATCAAATCATCCAATTAGAGAATCTAAGTATAATTGTCCTAATGAGATTGAGTCATCCGT
GCAATGGCGAGCATTTCTTTTCTATACATTGGAATACTTCATCGAGAATAAGCTCAACAATTTTGAATTAACATGGAGTA
AGTGGTGTAAAAATGCAAATGCAATCCTTATCAATCTTCATCAGCAACCGTTCATAACTGATGAATTAAAACCTATAGTA
GAGGAAGTATTTTCCTTATCTATAAAAGCTCCTTCAGGACTTGCAAAAATTAATGTTTCGGAGTTCACTGCAATAGAAAA
AGTAAATACTGAAAATTATAAATATGCTACAATTCATAGCGTTAAAGGTGAAACTCATGATGTAACAATTCTATTATCAT
CGCCTTCAAACTCCGGAAATAATGGTTCACACTGGAAACAGTGGATAAGTAATCAAAAATCAGAATCAACCAGATTTGCC
TATGTTGCAAGCTCAAGGCCTAGATATCGATTAGTCTGGGGTGTCAAAAAATTAAAAAATAGTGAAGCTGATACATTAAG
AAAACTTGGTTTTACTATTGAATGA

Upstream 100 bases:

>100_bases
TAGGAAAAGGATATTTCGCACAAAGTCTTTCAGATAACATATTAAATAATAGAGTTAAATTTGAAACACCAGAATATATT
AAAAATGCTATTCTCTGGGT

Downstream 100 bases:

>100_bases
AGATATTTTTACCTGCTTCATTCATTGTGAGTTGAAGCAGGTTGCAATTAGTTCTGTCAATTATTAATGATCAAATCTCC
ATACCACTGCATCATCTCCC

Product: helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MPRWRGIKMTHFNSQQMDYIESSIASSIYLEACPGSGKTEVIAAKVAKEINNWTLSPSGIALLSFSNSATDELFSRVKKY
SPDTVSRFPHFIGTFDSFIFKFLIGPNAKCLTHFEGECNKNTLRIIESASPLFIQTKYAYNKRGKIKAHHYTFDRRNDSI
LFNSDSPELDRMRNAINLQEWQIKDLIETKYKLFKSGLMTHDDSLFLAAEIFINEKYKNYALLLSKRFPLIIIDECQDLS
YEHLFILQGLHDLGVKLHFVGDLEQSIYGFRAVDPKDTIKFITDNEFERMPLKINYRSCQQIIDLCSKLTAHDGVNGQFS
SIESPCIVLQYNETPLELIDKIGQLCFGYSNNVIVARGHSILEKFTFNGVEDNIVKNLVNAINIFSLHGTQNIKNSLQLF
STVIRARSNHPIRESKYNCPNEIESSVQWRAFLFYTLEYFIENKLNNFELTWSKWCKNANAILINLHQQPFITDELKPIV
EEVFSLSIKAPSGLAKINVSEFTAIEKVNTENYKYATIHSVKGETHDVTILLSSPSNSGNNGSHWKQWISNQKSESTRFA
YVASSRPRYRLVWGVKKLKNSEADTLRKLGFTIE

Sequences:

>Translated_594_residues
MPRWRGIKMTHFNSQQMDYIESSIASSIYLEACPGSGKTEVIAAKVAKEINNWTLSPSGIALLSFSNSATDELFSRVKKY
SPDTVSRFPHFIGTFDSFIFKFLIGPNAKCLTHFEGECNKNTLRIIESASPLFIQTKYAYNKRGKIKAHHYTFDRRNDSI
LFNSDSPELDRMRNAINLQEWQIKDLIETKYKLFKSGLMTHDDSLFLAAEIFINEKYKNYALLLSKRFPLIIIDECQDLS
YEHLFILQGLHDLGVKLHFVGDLEQSIYGFRAVDPKDTIKFITDNEFERMPLKINYRSCQQIIDLCSKLTAHDGVNGQFS
SIESPCIVLQYNETPLELIDKIGQLCFGYSNNVIVARGHSILEKFTFNGVEDNIVKNLVNAINIFSLHGTQNIKNSLQLF
STVIRARSNHPIRESKYNCPNEIESSVQWRAFLFYTLEYFIENKLNNFELTWSKWCKNANAILINLHQQPFITDELKPIV
EEVFSLSIKAPSGLAKINVSEFTAIEKVNTENYKYATIHSVKGETHDVTILLSSPSNSGNNGSHWKQWISNQKSESTRFA
YVASSRPRYRLVWGVKKLKNSEADTLRKLGFTIE
>Mature_593_residues
PRWRGIKMTHFNSQQMDYIESSIASSIYLEACPGSGKTEVIAAKVAKEINNWTLSPSGIALLSFSNSATDELFSRVKKYS
PDTVSRFPHFIGTFDSFIFKFLIGPNAKCLTHFEGECNKNTLRIIESASPLFIQTKYAYNKRGKIKAHHYTFDRRNDSIL
FNSDSPELDRMRNAINLQEWQIKDLIETKYKLFKSGLMTHDDSLFLAAEIFINEKYKNYALLLSKRFPLIIIDECQDLSY
EHLFILQGLHDLGVKLHFVGDLEQSIYGFRAVDPKDTIKFITDNEFERMPLKINYRSCQQIIDLCSKLTAHDGVNGQFSS
IESPCIVLQYNETPLELIDKIGQLCFGYSNNVIVARGHSILEKFTFNGVEDNIVKNLVNAINIFSLHGTQNIKNSLQLFS
TVIRARSNHPIRESKYNCPNEIESSVQWRAFLFYTLEYFIENKLNNFELTWSKWCKNANAILINLHQQPFITDELKPIVE
EVFSLSIKAPSGLAKINVSEFTAIEKVNTENYKYATIHSVKGETHDVTILLSSPSNSGNNGSHWKQWISNQKSESTRFAY
VASSRPRYRLVWGVKKLKNSEADTLRKLGFTIE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 68122; Mature: 67991

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRWRGIKMTHFNSQQMDYIESSIASSIYLEACPGSGKTEVIAAKVAKEINNWTLSPSGI
CCCCCCEEEEECCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCEECCCCE
ALLSFSNSATDELFSRVKKYSPDTVSRFPHFIGTFDSFIFKFLIGPNAKCLTHFEGECNK
EEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
NTLRIIESASPLFIQTKYAYNKRGKIKAHHYTFDRRNDSILFNSDSPELDRMRNAINLQE
CEEEEEECCCCEEEEEEECCCCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHCCCHH
WQIKDLIETKYKLFKSGLMTHDDSLFLAAEIFINEKYKNYALLLSKRFPLIIIDECQDLS
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEEECCCCEEEEECCCCCC
YEHLFILQGLHDLGVKLHFVGDLEQSIYGFRAVDPKDTIKFITDNEFERMPLKINYRSCQ
CCHHHEECCHHHCCEEEEEECCHHHHHCCEECCCHHHHEEEEECCCCCCCCEEECHHHHH
QIIDLCSKLTAHDGVNGQFSSIESPCIVLQYNETPLELIDKIGQLCFGYSNNVIVARGHS
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCHH
ILEKFTFNGVEDNIVKNLVNAINIFSLHGTQNIKNSLQLFSTVIRARSNHPIRESKYNCP
HHHHHHCCCCHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NEIESSVQWRAFLFYTLEYFIENKLNNFELTWSKWCKNANAILINLHQQPFITDELKPIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCEEEEEECCCCCCHHHHHHHH
EEVFSLSIKAPSGLAKINVSEFTAIEKVNTENYKYATIHSVKGETHDVTILLSSPSNSGN
HHHHHEEECCCCCCEEEEHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCC
NGSHWKQWISNQKSESTRFAYVASSRPRYRLVWGVKKLKNSEADTLRKLGFTIE
CCHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
PRWRGIKMTHFNSQQMDYIESSIASSIYLEACPGSGKTEVIAAKVAKEINNWTLSPSGI
CCCCCEEEEECCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCEECCCCE
ALLSFSNSATDELFSRVKKYSPDTVSRFPHFIGTFDSFIFKFLIGPNAKCLTHFEGECNK
EEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
NTLRIIESASPLFIQTKYAYNKRGKIKAHHYTFDRRNDSILFNSDSPELDRMRNAINLQE
CEEEEEECCCCEEEEEEECCCCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHCCCHH
WQIKDLIETKYKLFKSGLMTHDDSLFLAAEIFINEKYKNYALLLSKRFPLIIIDECQDLS
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEEECCCCEEEEECCCCCC
YEHLFILQGLHDLGVKLHFVGDLEQSIYGFRAVDPKDTIKFITDNEFERMPLKINYRSCQ
CCHHHEECCHHHCCEEEEEECCHHHHHCCEECCCHHHHEEEEECCCCCCCCEEECHHHHH
QIIDLCSKLTAHDGVNGQFSSIESPCIVLQYNETPLELIDKIGQLCFGYSNNVIVARGHS
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCHH
ILEKFTFNGVEDNIVKNLVNAINIFSLHGTQNIKNSLQLFSTVIRARSNHPIRESKYNCP
HHHHHHCCCCHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NEIESSVQWRAFLFYTLEYFIENKLNNFELTWSKWCKNANAILINLHQQPFITDELKPIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCEEEEEECCCCCCHHHHHHHH
EEVFSLSIKAPSGLAKINVSEFTAIEKVNTENYKYATIHSVKGETHDVTILLSSPSNSGN
HHHHHEEECCCCCCEEEEHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCC
NGSHWKQWISNQKSESTRFAYVASSRPRYRLVWGVKKLKNSEADTLRKLGFTIE
CCHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA