Click here to switch to the map view.

The map label for this gene is lysR [H]

Identifier: 218550089

GI number: 218550089

Start: 2840982

End: 2841917

Strand: Direct

Name: lysR [H]

Synonym: EFER_2774

Alternate gene names: 218550089

Gene position: 2840982-2841917 (Clockwise)

Preceding gene: 218550087

Following gene: 218550091

Centisome position: 61.91

GC content: 52.14

Gene sequence:

>936_bases
ATGGCTGCCGTCACTCTACGTCATATAGAAATATTCCACGCGGTGATGACCGCCGGAAGCCTGACCGAAGCGGCTCGTTT
GCTGCATACTTCGCAACCGACGGTCAGCCGGGAACTGGCACGGTGTGAAAAATTGCTCGGGCTAAAGCTCTTTGAGCGAA
CACGTGGACGCTTACACCCAACGGTGCAAGGTTTGCGCTTGTTTGAAGAAGTGCAACGTTCATGGTATGGGCTGGATCGC
ATTGTGAGTGCGGCAGAAAGCCTGCGTGAATTTCGTCAGGGCGAGCTTTCTATTGTCTGTCTGCCAGTTTTTTCCCAATC
CTTACTACCGCCGCTATTGCAGCCATTTCTCGCCCGCTACCCGGATGTCAGTTTAAATGTTGTTCCTCAGGAGTCACCGT
TACTGGAAGAGTGGCTATCTGCCCAACGTCACGATCTGGGATTAACAGAAACGCTGCATACGCCTGCGGGAACTGAGCGT
ACGGAGTTGCTTTCCCTGGATGAAGTCTGCGTCTTACCGCCGGGGCATCCGCTGGCAGCAAAACATTGTTTAACGCCTCA
GGATTTTCAGGGAGAGAACTATATCAGTCTCTCCCGCACTGACAGTTACCGTCAGTTGCTGGATAGTTTATTTACAGAGC
ATCAGGTGAAACGGCGGATGGTCGTTGAAACACACAGTGCCGCGTCAGTATGTGCGATGGTACGTGCAGGTGCTGGGGTT
TCTGTCGTAAACCCACTCACTGCGCTGGATTATGCTGCCAGTGGCGTGGAAGTACGTCGTTTTAGTATTGCCGTGCCATT
CACGATAAGTCTGATTCGCCCCTTGCACCGCCCCTCTTCTGCACTGGTCGATGCTTTTAGTGAACACTTACAAACCAGCT
TACAGGGCCTGGTAACTTCACTTGATGCCATCCTGCAAGGTGCAAAGCAACATTAA

Upstream 100 bases:

>100_bases
CTCTTTTTTTTATGATTACGCCACAGGAAAAACCGAATAAAAAATATCGTTTTTTCGTAAGTCTATGCAAAAATGATATG
GATTAATGCTGGAGAAAATA

Downstream 100 bases:

>100_bases
CGGCTTATTCGTCGCGCTCTATCGTTAAAGCCACGCCCTGACCACCGCCGATGCAAAGCGTCGCCAGCCCTTTACGCGCT
TTGCGTTTGACCATTTCATG

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAAVTLRHIEIFHAVMTAGSLTEAARLLHTSQPTVSRELARCEKLLGLKLFERTRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIVCLPVFSQSLLPPLLQPFLARYPDVSLNVVPQESPLLEEWLSAQRHDLGLTETLHTPAGTER
TELLSLDEVCVLPPGHPLAAKHCLTPQDFQGENYISLSRTDSYRQLLDSLFTEHQVKRRMVVETHSAASVCAMVRAGAGV
SVVNPLTALDYAASGVEVRRFSIAVPFTISLIRPLHRPSSALVDAFSEHLQTSLQGLVTSLDAILQGAKQH

Sequences:

>Translated_311_residues
MAAVTLRHIEIFHAVMTAGSLTEAARLLHTSQPTVSRELARCEKLLGLKLFERTRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIVCLPVFSQSLLPPLLQPFLARYPDVSLNVVPQESPLLEEWLSAQRHDLGLTETLHTPAGTER
TELLSLDEVCVLPPGHPLAAKHCLTPQDFQGENYISLSRTDSYRQLLDSLFTEHQVKRRMVVETHSAASVCAMVRAGAGV
SVVNPLTALDYAASGVEVRRFSIAVPFTISLIRPLHRPSSALVDAFSEHLQTSLQGLVTSLDAILQGAKQH
>Mature_310_residues
AAVTLRHIEIFHAVMTAGSLTEAARLLHTSQPTVSRELARCEKLLGLKLFERTRGRLHPTVQGLRLFEEVQRSWYGLDRI
VSAAESLREFRQGELSIVCLPVFSQSLLPPLLQPFLARYPDVSLNVVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERT
ELLSLDEVCVLPPGHPLAAKHCLTPQDFQGENYISLSRTDSYRQLLDSLFTEHQVKRRMVVETHSAASVCAMVRAGAGVS
VVNPLTALDYAASGVEVRRFSIAVPFTISLIRPLHRPSSALVDAFSEHLQTSLQGLVTSLDAILQGAKQH

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=308, Percent_Identity=90.5844155844156, Blast_Score=563, Evalue=1e-162,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=28.2608695652174, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693105, Length=238, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788887, Length=250, Percent_Identity=28.4, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787530, Length=226, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788481, Length=304, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=25.2, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790262, Length=211, Percent_Identity=28.436018957346, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787879, Length=308, Percent_Identity=26.6233766233766, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081904, Length=180, Percent_Identity=30, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34433; Mature: 34302

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVTLRHIEIFHAVMTAGSLTEAARLLHTSQPTVSRELARCEKLLGLKLFERTRGRLHP
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIVCLPVFSQSLLPPLLQPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHC
PDVSLNVVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTELLSLDEVCVLPPGHPLAA
CCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHCCCCCEEECCCCCCHHH
KHCLTPQDFQGENYISLSRTDSYRQLLDSLFTEHQVKRRMVVETHSAASVCAMVRAGAGV
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVVNPLTALDYAASGVEVRRFSIAVPFTISLIRPLHRPSSALVDAFSEHLQTSLQGLVTS
HHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LDAILQGAKQH
HHHHHHHHCCC
>Mature Secondary Structure 
AAVTLRHIEIFHAVMTAGSLTEAARLLHTSQPTVSRELARCEKLLGLKLFERTRGRLHP
CCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIVCLPVFSQSLLPPLLQPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHC
PDVSLNVVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTELLSLDEVCVLPPGHPLAA
CCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHCCCCCEEECCCCCCHHH
KHCLTPQDFQGENYISLSRTDSYRQLLDSLFTEHQVKRRMVVETHSAASVCAMVRAGAGV
HHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVVNPLTALDYAASGVEVRRFSIAVPFTISLIRPLHRPSSALVDAFSEHLQTSLQGLVTS
HHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LDAILQGAKQH
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]