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The map label for this gene is galR [H]

Identifier: 218550087

GI number: 218550087

Start: 2838567

End: 2839595

Strand: Direct

Name: galR [H]

Synonym: EFER_2772

Alternate gene names: 218550087

Gene position: 2838567-2839595 (Clockwise)

Preceding gene: 218550083

Following gene: 218550089

Centisome position: 61.86

GC content: 53.06

Gene sequence:

>1029_bases
ATGGCGACAATAAAGGATGTAGCCCGACTGGCTGGTGTTTCAGTCGCCACCGTCTCTCGCGTTATTAATGGTTCCCCAAA
AGCAAGCGAAGCATCGCGGATTGCGGTGCAAAGCGCAATGGAATCGCTCAGCTACCATCCAAATGCTAATGCACGTGCAT
TGGCCCAACAGGCAACTGAAACTGTCGGTCTGGTGGTAGGTGATGTTTCCGATCCCTTTTTCGGTGCGATGGTAAAAGCG
GTTGAGCAGGTGGCCTATAACACCGGCAATTTTCTGCTGATTGGTAATGGTTACCACGATGAGCAAAAAGAGCGCCAGGC
TATTGAGCAACTAATGCGCCATCGCTGTGCCGCACTGGTCGTACACGCCAAAATGATCCCGGATGAAGACCTGGCGTCAT
TAATGAAACAAATGCCGGGGATGGTATTGATCAACCGAATTCTTCCTGGGTTTGAGAATCGTTGCATCGCCCTGGACGAT
CGCTACGGGGCATGGCTGGCAACGCGCCACTTAATTCAGCAGGGCCATACACGGATTGGCTATCTCTGTTCTAATCATTC
CATTTCTGACGCCGAAGATCGTTTGCAAGGTTATTACGACGCCCTTGCAGAAAGCGGTATTACGGCGAATGACAGGCTGG
TGACATTTGGTGAACCAGATGAAAGTGGTGGTGAACAGGCGATGACTGAATTGTTGGGGCGGGGAAGAAATTTCACTGCC
GTGGCCTGTTATAACGACTCAATGGCTGCTGGCGCGATGGGTGTTCTCAATGACAATGGCATCGACGTACCTGGCGAGAT
CTCACTGATTGGTTTCGATGATGTACTGGTATCACGCTACGTCCGCCCACGCTTAACCACCGTGCGTTATCCGGTGGTGA
CGATGGCAACCCAGGCCGCAGAACTGGCACTGGCGCTGGCAGAAAAACGTCCGCTCCCGGAAGTCACGCACGTTTTCATC
CCTACCCTGGTGCGCAGGCACTCCGTGACGCCGCCACTGGAAGCCAGTCATTCAGCTTCCAGCAACTGA

Upstream 100 bases:

>100_bases
GACGCACATTTCCTTCTCCCCGCGCCGTAAGCCCCTTGAACACGCCATCATTTTCCGTAACACTGGCACAATGTAAGCGT
TTACCCACAAAGGTATTTTC

Downstream 100 bases:

>100_bases
ACACAAGCTGGCACTCAGATTAACTCCAGTGCCAGTAACTCCTCAATAGTTTGGCGACGACGAATTAACCGCGCCTGACC
ATTATCAAACAGTACTTCTG

Product: DNA-binding transcriptional regulator GalR

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MATIKDVARLAGVSVATVSRVINGSPKASEASRIAVQSAMESLSYHPNANARALAQQATETVGLVVGDVSDPFFGAMVKA
VEQVAYNTGNFLLIGNGYHDEQKERQAIEQLMRHRCAALVVHAKMIPDEDLASLMKQMPGMVLINRILPGFENRCIALDD
RYGAWLATRHLIQQGHTRIGYLCSNHSISDAEDRLQGYYDALAESGITANDRLVTFGEPDESGGEQAMTELLGRGRNFTA
VACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPVVTMATQAAELALALAEKRPLPEVTHVFI
PTLVRRHSVTPPLEASHSASSN

Sequences:

>Translated_342_residues
MATIKDVARLAGVSVATVSRVINGSPKASEASRIAVQSAMESLSYHPNANARALAQQATETVGLVVGDVSDPFFGAMVKA
VEQVAYNTGNFLLIGNGYHDEQKERQAIEQLMRHRCAALVVHAKMIPDEDLASLMKQMPGMVLINRILPGFENRCIALDD
RYGAWLATRHLIQQGHTRIGYLCSNHSISDAEDRLQGYYDALAESGITANDRLVTFGEPDESGGEQAMTELLGRGRNFTA
VACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPVVTMATQAAELALALAEKRPLPEVTHVFI
PTLVRRHSVTPPLEASHSASSN
>Mature_341_residues
ATIKDVARLAGVSVATVSRVINGSPKASEASRIAVQSAMESLSYHPNANARALAQQATETVGLVVGDVSDPFFGAMVKAV
EQVAYNTGNFLLIGNGYHDEQKERQAIEQLMRHRCAALVVHAKMIPDEDLASLMKQMPGMVLINRILPGFENRCIALDDR
YGAWLATRHLIQQGHTRIGYLCSNHSISDAEDRLQGYYDALAESGITANDRLVTFGEPDESGGEQAMTELLGRGRNFTAV
ACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPVVTMATQAAELALALAEKRPLPEVTHVFIP
TLVRRHSVTPPLEASHSASSN

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789202, Length=343, Percent_Identity=94.1690962099125, Blast_Score=648, Evalue=0.0,
Organism=Escherichia coli, GI1788474, Length=329, Percent_Identity=55.3191489361702, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1789068, Length=337, Percent_Identity=34.4213649851632, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1790369, Length=303, Percent_Identity=32.3432343234323, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=32.7327327327327, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=32.1212121212121, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787906, Length=332, Percent_Identity=28.9156626506024, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=26.8221574344023, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787580, Length=320, Percent_Identity=26.25, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790715, Length=319, Percent_Identity=25.3918495297806, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994940, Length=307, Percent_Identity=22.8013029315961, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790689, Length=319, Percent_Identity=25.0783699059561, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786268, Length=128, Percent_Identity=32.8125, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36990; Mature: 36858

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVARLAGVSVATVSRVINGSPKASEASRIAVQSAMESLSYHPNANARALAQQATE
CCCHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TVGLVVGDVSDPFFGAMVKAVEQVAYNTGNFLLIGNGYHDEQKERQAIEQLMRHRCAALV
HHEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VHAKMIPDEDLASLMKQMPGMVLINRILPGFENRCIALDDRYGAWLATRHLIQQGHTRIG
HHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEE
YLCSNHSISDAEDRLQGYYDALAESGITANDRLVTFGEPDESGGEQAMTELLGRGRNFTA
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEE
VACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPVVTMATQAA
EEEECCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHCCCHHEEECHHHHHHHHHH
ELALALAEKRPLPEVTHVFIPTLVRRHSVTPPLEASHSASSN
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATIKDVARLAGVSVATVSRVINGSPKASEASRIAVQSAMESLSYHPNANARALAQQATE
CCHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TVGLVVGDVSDPFFGAMVKAVEQVAYNTGNFLLIGNGYHDEQKERQAIEQLMRHRCAALV
HHEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VHAKMIPDEDLASLMKQMPGMVLINRILPGFENRCIALDDRYGAWLATRHLIQQGHTRIG
HHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEE
YLCSNHSISDAEDRLQGYYDALAESGITANDRLVTFGEPDESGGEQAMTELLGRGRNFTA
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEE
VACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPVVTMATQAA
EEEECCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHCCCHHEEECHHHHHHHHHH
ELALALAEKRPLPEVTHVFIPTLVRRHSVTPPLEASHSASSN
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6283521; 9278503; 6350601; 8188660; 8982002 [H]