| Definition | Escherichia fergusonii ATCC 35469 chromosome, complete genome. |
|---|---|
| Accession | NC_011740 |
| Length | 4,588,711 |
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The map label for this gene is yvgN [H]
Identifier: 218549987
GI number: 218549987
Start: 2750728
End: 2751579
Strand: Direct
Name: yvgN [H]
Synonym: EFER_2672
Alternate gene names: 218549987
Gene position: 2750728-2751579 (Clockwise)
Preceding gene: 218549986
Following gene: 218549988
Centisome position: 59.95
GC content: 51.41
Gene sequence:
>852_bases ATGCAAACTGTAAAACTGAACAACGGTATTGAAATGCCCTTGCTGGGCTTTGGTGTCTTCCAGATGACGGATGCTGCTGA ATGCGAAAGAGCCGTTATTGATGCGATCGATACGGGATACCGCCTGATCGATACCGCAGCGTCTTACCAGAATGAAACCC AGGTCGGGAATGCGCTGAAACAAAGCGGCATTGCGCGTAACGAACTCTTTGTCACCACGAAACTCTGGTTGCAGGATACC AGTTACGAAGGGGCCAAAGCCCAGTTCGAACGCTCTCTGAATCGACTGCAACTTGATTACGTTGACCTGTACTTGATTCA CCAGCCATACGGCGATGTCCACGGAGCCTGGCGTGCCATGGAAGAGCTGCAACAGGCCGGTAAAATTCGCGCTATTGGCG TCAGCAACTTCCACCCTGACCGACTGGCTGACCTTATCGCCTTTAATAAAGTCGTTCCTGCGGTAAACCAGATTGAAGTT AACCCCTTCAACCAGCAGCTACACGCCGTTCCGTGGATGCAAAGTCGTGGCATTCAGCCAGAAGCCTGGGCACCGTTTGC GGAAGGGAAAAATGGTCTGTTCCAGCATCCTGTTCTCACGGCAATTGGCGAGAAGTATGGCAAAAGCGTGGGCCAGGTTA TTCTGCGCTGGATTTACCAACGAGGCATTGTTTCACTGGCAAAATCAGTGCGCAAAGAGCGCATGGAAGAGAACATCAAC ATTCTCGATTTTGAACTCACTCCTGAAGATATGCTGCAAATTACCGCCCTGGATACCGCAACCAGCGCGTTCTTCTCTCA CCGCGACCCAGCGATGGTGGAATGGCTGACTGGCCGCAAACTTGATGTTTAA
Upstream 100 bases:
>100_bases TTAATGAACACAACTAATAAACCCTAGCAAATTACCCCATCTAATCGCATAAATAACTTTTCGTTATGCTTTTCCTACAC AACAGCTGAAGGATAACGTC
Downstream 100 bases:
>100_bases GCCGTAATACAAGAGGTATTCATTCAATGCAAAAACGTTATCTGGGTAATTCCGGACTCGAAGTTTCCGCTCTTGGACTC GGTTGCATGGGCTTAAGCCA
Product: aldo-keto reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 283; Mature: 283
Protein sequence:
>283_residues MQTVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAIDTGYRLIDTAASYQNETQVGNALKQSGIARNELFVTTKLWLQDT SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNKVVPAVNQIEV NPFNQQLHAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVILRWIYQRGIVSLAKSVRKERMEENIN ILDFELTPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV
Sequences:
>Translated_283_residues MQTVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAIDTGYRLIDTAASYQNETQVGNALKQSGIARNELFVTTKLWLQDT SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNKVVPAVNQIEV NPFNQQLHAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVILRWIYQRGIVSLAKSVRKERMEENIN ILDFELTPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV >Mature_283_residues MQTVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAIDTGYRLIDTAASYQNETQVGNALKQSGIARNELFVTTKLWLQDT SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNKVVPAVNQIEV NPFNQQLHAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVILRWIYQRGIVSLAKSVRKERMEENIN ILDFELTPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=34.4827586206897, Blast_Score=185, Evalue=5e-47, Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=34.4827586206897, Blast_Score=185, Evalue=5e-47, Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=36.3636363636364, Blast_Score=167, Evalue=8e-42, Organism=Homo sapiens, GI310109920, Length=296, Percent_Identity=34.4594594594595, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI45446745, Length=296, Percent_Identity=34.4594594594595, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI4503285, Length=296, Percent_Identity=34.4594594594595, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI5453543, Length=295, Percent_Identity=33.5593220338983, Blast_Score=164, Evalue=1e-40, Organism=Homo sapiens, GI24497583, Length=303, Percent_Identity=33.003300330033, Blast_Score=163, Evalue=2e-40, Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=33.5593220338983, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=32.4137931034483, Blast_Score=156, Evalue=2e-38, Organism=Homo sapiens, GI24497585, Length=296, Percent_Identity=33.445945945946, Blast_Score=155, Evalue=4e-38, Organism=Homo sapiens, GI4502049, Length=306, Percent_Identity=35.6209150326797, Blast_Score=150, Evalue=9e-37, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=32.0143884892086, Blast_Score=146, Evalue=3e-35, Organism=Homo sapiens, GI93277124, Length=298, Percent_Identity=31.2080536912752, Blast_Score=145, Evalue=4e-35, Organism=Homo sapiens, GI291291012, Length=281, Percent_Identity=30.9608540925267, Blast_Score=137, Evalue=1e-32, Organism=Homo sapiens, GI300116271, Length=271, Percent_Identity=32.1033210332103, Blast_Score=136, Evalue=2e-32, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=44.7368421052632, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=44.7368421052632, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI310109924, Length=151, Percent_Identity=31.7880794701987, Blast_Score=83, Evalue=2e-16, Organism=Escherichia coli, GI87082198, Length=259, Percent_Identity=42.0849420849421, Blast_Score=208, Evalue=3e-55, Organism=Escherichia coli, GI1786400, Length=253, Percent_Identity=34.7826086956522, Blast_Score=147, Evalue=6e-37, Organism=Escherichia coli, GI1788081, Length=269, Percent_Identity=28.6245353159851, Blast_Score=97, Evalue=2e-21, Organism=Escherichia coli, GI48994888, Length=243, Percent_Identity=27.5720164609054, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1788070, Length=190, Percent_Identity=26.8421052631579, Blast_Score=61, Evalue=9e-11, Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=36.3295880149813, Blast_Score=173, Evalue=1e-43, Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=34.3137254901961, Blast_Score=169, Evalue=1e-42, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=33.6996336996337, Blast_Score=166, Evalue=2e-41, Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=32.8767123287671, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17537075, Length=292, Percent_Identity=32.8767123287671, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=33.0985915492958, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17537079, Length=295, Percent_Identity=30.8474576271186, Blast_Score=145, Evalue=2e-35, Organism=Caenorhabditis elegans, GI17566692, Length=276, Percent_Identity=33.695652173913, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17552492, Length=280, Percent_Identity=30.7142857142857, Blast_Score=137, Evalue=5e-33, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=28.0575539568345, Blast_Score=134, Evalue=5e-32, Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=31.021897810219, Blast_Score=133, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17538386, Length=275, Percent_Identity=30.9090909090909, Blast_Score=127, Evalue=9e-30, Organism=Saccharomyces cerevisiae, GI6320576, Length=286, Percent_Identity=38.8111888111888, Blast_Score=182, Evalue=5e-47, Organism=Saccharomyces cerevisiae, GI6324694, Length=287, Percent_Identity=37.6306620209059, Blast_Score=181, Evalue=1e-46, Organism=Saccharomyces cerevisiae, GI6321896, Length=325, Percent_Identity=32.3076923076923, Blast_Score=152, Evalue=8e-38, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=33.587786259542, Blast_Score=144, Evalue=1e-35, Organism=Saccharomyces cerevisiae, GI6320079, Length=285, Percent_Identity=32.280701754386, Blast_Score=132, Evalue=5e-32, Organism=Saccharomyces cerevisiae, GI6319625, Length=286, Percent_Identity=29.020979020979, Blast_Score=109, Evalue=4e-25, Organism=Drosophila melanogaster, GI24663317, Length=281, Percent_Identity=35.5871886120996, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI24657054, Length=278, Percent_Identity=37.7697841726619, Blast_Score=174, Evalue=6e-44, Organism=Drosophila melanogaster, GI45553081, Length=291, Percent_Identity=34.3642611683849, Blast_Score=168, Evalue=4e-42, Organism=Drosophila melanogaster, GI24644950, Length=296, Percent_Identity=35.472972972973, Blast_Score=167, Evalue=9e-42, Organism=Drosophila melanogaster, GI21356425, Length=310, Percent_Identity=33.8709677419355, Blast_Score=166, Evalue=1e-41, Organism=Drosophila melanogaster, GI20129731, Length=278, Percent_Identity=36.6906474820144, Blast_Score=164, Evalue=6e-41, Organism=Drosophila melanogaster, GI221378297, Length=316, Percent_Identity=33.2278481012658, Blast_Score=159, Evalue=2e-39, Organism=Drosophila melanogaster, GI24662789, Length=290, Percent_Identity=35.5172413793103, Blast_Score=158, Evalue=4e-39, Organism=Drosophila melanogaster, GI24662781, Length=281, Percent_Identity=33.4519572953737, Blast_Score=135, Evalue=3e-32, Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=32.156862745098, Blast_Score=131, Evalue=5e-31, Organism=Drosophila melanogaster, GI24662785, Length=274, Percent_Identity=33.2116788321168, Blast_Score=131, Evalue=6e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31923; Mature: 31923
Theoretical pI: Translated: 5.38; Mature: 5.38
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQTVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAIDTGYRLIDTAASYQNETQVGNALK CCEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH QSGIARNELFVTTKLWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAM HCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHH EELQQAGKIRAIGVSNFHPDRLADLIAFNKVVPAVNQIEVNPFNQQLHAVPWMQSRGIQP HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHEEECCCCCHHHHCCCCHHHCCCCC EAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVILRWIYQRGIVSLAKSVRKERMEENIN CCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC ILDFELTPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV EEEEEECHHHHHEEHHHHHHHHHHHHCCCCHHHHHHCCCCCCC >Mature Secondary Structure MQTVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAIDTGYRLIDTAASYQNETQVGNALK CCEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH QSGIARNELFVTTKLWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAM HCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHH EELQQAGKIRAIGVSNFHPDRLADLIAFNKVVPAVNQIEVNPFNQQLHAVPWMQSRGIQP HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHEEECCCCCHHHHCCCCHHHCCCCC EAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVILRWIYQRGIVSLAKSVRKERMEENIN CCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC ILDFELTPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV EEEEEECHHHHHEEHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]