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The map label for this gene is proC [H]

Identifier: 218549952

GI number: 218549952

Start: 2707566

End: 2708375

Strand: Direct

Name: proC [H]

Synonym: EFER_2637

Alternate gene names: 218549952

Gene position: 2707566-2708375 (Clockwise)

Preceding gene: 218549946

Following gene: 218549957

Centisome position: 59.0

GC content: 50.99

Gene sequence:

>810_bases
ATGGATAAAAAAATCGGGTTTATCGGCTGCGGTAATATGGGGAAAGCCATTCTGGGTGGTCTGATTGCCAGCGGTCAGGT
TCTGCCGGGGCAAATCTGGGTCTACACCCCCTCTCCTGAAAAAGTTGCCGAACTCCACGATCGCTTTGGGATTAATGCAG
CGCAGTCGGCGCAAGAGGTGGCGCAGATTGCTGATATCGTTTTTGCTGCCGTCAAACCCGGCATTATGGTGAAAGTGTTG
AGTGAAATCGCGTCCAGTCTGAATAAAGACTCGCTGGTGGTCTCAATTGCTGCCGGCGTTACTCTGGATCAACTGGCTCG
CGCTCTGGGACATGATCGTAAAATAATTCGCGCCATGCCAAACACTCCAGCACTGGTGAATGCGGGTATGACCTCAGTAA
CGCCAAACGCCCTGGTGACACCAGAAGATACCGCTGATGTACTGAATATTTTCCGCTGCTTTGGTGAAGCAGAAGTGATT
GCAGAATCGATGATTCACCCGGTTGTTGGAGTCAGTGGTTCTTCTCCGGCGTATGTATTTATGTTTATTGAAGCGATGGC
TGATGCGGCGGTGCTGGGCGGAATGCCACGCGCACAAGCGTATAAATTTGCCGCACAGGCCGTTATGGGATCAGCGAAAA
TGGTACTCGAAACCGGAGAACATCCAGGTGCACTGAAAGATATGGTGTGTTCGCCAGGAGGAACTACTATTGAAGCGGTG
CGCGTTCTGGAAGATCGAGGCTTCCGTGCTGCCGTGATCGAAGCTATGGCGAAGTGTATGGAAAAATCAGAACAACTCAG
TAAATCCTGA

Upstream 100 bases:

>100_bases
TTTGCTAATCAGCATAGTGTTGTTTCCCTTCAGGAGACGGTTGTTACGCGTTAAGCTAGTCTCCATTAATAAAACAATGA
CGATCAAAGGGGGTAGTGAG

Downstream 100 bases:

>100_bases
GTCTGGTGCCGGACGTCAGGCCGCCACTTCGGTGCGATTACGTCCGGCGCTCTTTGCTTTGTAGAGCGCCATATCTGCAG
ATTTTAACCATTCACGATAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPEKVAELHDRFGINAAQSAQEVAQIADIVFAAVKPGIMVKVL
SEIASSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVI
AESMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAV
RVLEDRGFRAAVIEAMAKCMEKSEQLSKS

Sequences:

>Translated_269_residues
MDKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPEKVAELHDRFGINAAQSAQEVAQIADIVFAAVKPGIMVKVL
SEIASSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVI
AESMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAV
RVLEDRGFRAAVIEAMAKCMEKSEQLSKS
>Mature_269_residues
MDKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPEKVAELHDRFGINAAQSAQEVAQIADIVFAAVKPGIMVKVL
SEIASSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVI
AESMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAV
RVLEDRGFRAAVIEAMAKCMEKSEQLSKS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=34.9624060150376, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=37.9699248120301, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=37.593984962406, Blast_Score=167, Evalue=7e-42,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=37.593984962406, Blast_Score=167, Evalue=7e-42,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=95.1672862453532, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=40.0763358778626, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=37.8091872791519, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=27.8745644599303, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=39.7111913357401, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=39.622641509434, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.603550295858, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28146; Mature: 28146

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPEKVAELHDRFGINAAQSAQEV
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHH
AQIADIVFAAVKPGIMVKVLSEIASSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMP
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHCC
NTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAESMIHPVVGVSGSSPAYVF
CCCCEEECCCCCCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHH
MFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHEEECCCCCCHHHHHHCCCCCCHHHHH
RVLEDRGFRAAVIEAMAKCMEKSEQLSKS
HHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPEKVAELHDRFGINAAQSAQEV
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHH
AQIADIVFAAVKPGIMVKVLSEIASSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMP
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHCC
NTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAESMIHPVVGVSGSSPAYVF
CCCCEEECCCCCCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHH
MFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHEEECCCCCCHHHHHHCCCCCCHHHHH
RVLEDRGFRAAVIEAMAKCMEKSEQLSKS
HHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]