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The map label for this gene is cadB [H]

Identifier: 218549241

GI number: 218549241

Start: 1946319

End: 1947653

Strand: Reverse

Name: cadB [H]

Synonym: EFER_1901

Alternate gene names: 218549241

Gene position: 1947653-1946319 (Counterclockwise)

Preceding gene: 218549242

Following gene: 218549240

Centisome position: 42.44

GC content: 49.81

Gene sequence:

>1335_bases
ATGAGTTCTGCCAAGAAGATCGGGCTATTTGCCTGTACCGGTGTGGTTGCCGGTAATATGATGGGGAGCGGTATTGCATT
ATTACCTGCGAACCTCGCAAGTATCGGTGGTATTGCTATCTGGGGTTGGATTATCTCTATTATTGGTGCAATGTCGCTGG
CTTATGTATATGCCCGACTGGCAACCAAAAACCCGCAGCAAGGTGGCCCAATTGCTTATGCCGGGGAAATTTCTCCTGCA
TTTGGTTTCCAGACGGGTGTTCTTTATTACCATGCTAACTGGATTGGTAACCTGGCGATTGGTATTACCGCCGTGTCTTA
TCTTTCCACCTTCTTCCCGGTATTAAATGACCCGGTTCCGGCAGGTATTGCCTGTATTGCCATTGTTTGGGTATTTACCT
TTGTAAATATGCTCGGTGGTACCTGGGTAAGCCGTTTAACCACAATTGGTCTGGTACTGGTTCTTATTCCGGTAGTAATG
ACCGCTATTGTCGGCTGGCACTGGTTTGATTCTGCTACTTATGCAGCTAACTGGAATACTGCACAAACCACTGATGGTCA
TGCGATCATTAAAAGTATTCTGCTCTGCCTGTGGGCCTTCGTGGGTGTTGAATCCGCAGCGGTAAGTACTGGTATGGTTA
AAAACCCGAAACGTACTGTTCCGCTGGCAACCATGTTGGGTACTGGTTTAGCAGGTATTGTTTACATCGCTGCGACTCAG
GTGCTTTCCGGTATGTATCCGTCTTCTGTAATGGCAGGCTCCGGTGCTCCGTTTGCAATCAGTGCTTCTACTATCCTGGG
TAACTGGGCTGCGCCGATGGTTTCTGCATTCACCGCGTTTGCGTGCCTGACTTCTCTGGGCTCCTGGATGATGCTGGTAG
GTCAGGCAGGTGTGCGTGCCGCTAACGACGGTAACTTCCCGAAAGTTTATGGTGAAGTCGACAGCAACGGTATTCCGAAA
AAAGGTCTGCTGCTGGCTGCAGTGAAAATGACTGCCCTGATGATCCTTATCACTCTGATGAACTCTGCTGGTGGTAAAGC
ATCTGACCTGTTCGGTGAACTGACCGGTATCGCAGTACTGCTGACTATGCTGCCGTACTTCTACTCTTGCGTTGACCTGA
TTCGCTTCGAAGGCGTTAACATCCGCAACTTTGCCAGCCTGATCTGCTCTGTACTGGGTTGCGTGTTCTGCTTCATCGCG
CTGATGGGGGCAAGCTCCTTCGAACTGGCTGGTACCTTCATCGTCAGCCTGATTATCCTGATGTTCTACGCTCGCAAAAT
GCATGAGCGCCAGAGCCACTCAATGGATAACCACACAGCGTCTAACGCCCATTAA

Upstream 100 bases:

>100_bases
CCCTTTTTCGTGAGTAATCTTATCGCCAGTTTGGTCTGGTCAATAAATGGTTCTACATCATGATCCGGACTTCCAAAATG
AACTTAGGAGAAAAGAAAGC

Downstream 100 bases:

>100_bases
TTAAAAGTATTTTCCGAAAGCGCCTCCTTTCATTTGTCCCATGTGTTGGGAGGGGCTTTCTTTACCTGGAGATATTACTA
TGAACGTTATTGCAATATTG

Product: lysine/cadaverine antiporter

Products: cadaverine [Cytoplasm]; L-lysine [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVPAGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAIVGWHWFDSATYAANWNTAQTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQ
VLSGMYPSSVMAGSGAPFAISASTILGNWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPK
KGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGVNIRNFASLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYARKMHERQSHSMDNHTASNAH

Sequences:

>Translated_444_residues
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVPAGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAIVGWHWFDSATYAANWNTAQTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQ
VLSGMYPSSVMAGSGAPFAISASTILGNWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPK
KGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGVNIRNFASLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYARKMHERQSHSMDNHTASNAH
>Mature_443_residues
SSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPAF
GFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVPAGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVMT
AIVGWHWFDSATYAANWNTAQTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQV
LSGMYPSSVMAGSGAPFAISASTILGNWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPKK
GLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGVNIRNFASLICSVLGCVFCFIAL
MGASSFELAGTFIVSLIILMFYARKMHERQSHSMDNHTASNAH

Specific function: Probable cadaverine/lysine antiporter or part of it [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790575, Length=444, Percent_Identity=98.8738738738739, Blast_Score=880, Evalue=0.0,
Organism=Escherichia coli, GI2367353, Length=447, Percent_Identity=38.4787472035794, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1786908, Length=417, Percent_Identity=32.1342925659472, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1787890, Length=447, Percent_Identity=23.0425055928412, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082250, Length=324, Percent_Identity=26.5432098765432, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982612, Length=338, Percent_Identity=24.2603550295858, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71982608, Length=338, Percent_Identity=24.2603550295858, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221331183, Length=333, Percent_Identity=25.8258258258258, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647653, Length=333, Percent_Identity=25.8258258258258, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664379, Length=333, Percent_Identity=25.8258258258258, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46671; Mature: 46539

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARL
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVP
HCCCCCCCCCEEEECCCCCCCCCHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAIVGWHWFDSATYAANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
AQTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VLSGMYPSSVMAGSGAPFAISASTILGNWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHCCCCCHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKVYGEVDSNGIPKKGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVL
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGVNIRNFASLICSVLGCVFCFIALMGASSFELAGTFIVSLIIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MFYARKMHERQSHSMDNHTASNAH
HHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARL
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVP
HCCCCCCCCCEEEECCCCCCCCCHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAIVGWHWFDSATYAANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
AQTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VLSGMYPSSVMAGSGAPFAISASTILGNWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHCCCCCHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKVYGEVDSNGIPKKGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVL
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGVNIRNFASLICSVLGCVFCFIALMGASSFELAGTFIVSLIIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MFYARKMHERQSHSMDNHTASNAH
HHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cadaverine [Cytoplasm]; Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: cadaverine [Cytoplasm] + Proton [Periplasm] + L-lysine [Periplasm] = cadaverine [Cytoplasm] + L-lysine [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]