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The map label for this gene is cadA [H]

Identifier: 218549240

GI number: 218549240

Start: 1944092

End: 1946239

Strand: Reverse

Name: cadA [H]

Synonym: EFER_1900

Alternate gene names: 218549240

Gene position: 1946239-1944092 (Counterclockwise)

Preceding gene: 218549241

Following gene: 218549239

Centisome position: 42.41

GC content: 47.49

Gene sequence:

>2148_bases
ATGAACGTTATTGCAATATTGAATCACATGGGGGTTTACTTTAAAGAAGAACCCATCCGTGAACTTCATCGTGCGCTTGA
GCGTCTGAACTTCCAGATTGTTTACCCGAATGACCGTGACGACTTATTAAAACTGATCGAAAACAATGCGCGTCTGTGCG
GCGTTATTTTTGACTGGGATAAATATAATCTCGAGTTGTGCGAAGAAATTAGCAAAATGAACGAGAACTTACCGTTGTAC
GCGTTCGCTAATACGTATTCCACACTCGATGTAAGCCTGAACGATCTGCGTTTACAGATTAGCTTCTTTGAATATGCGCT
GGGTGCTGCTGATGATATTGCTAATAAGATCAAGCAGACCACAGACGAATATATCAACACTATTCTGCCTCCACTGACTA
AAGCGCTGTTTAAATATGTACGTGAAGGTAAATATACTTTCTGTACTCCTGGCCACATGGGCGGTACTGCATTCCAGAAA
AGCCCGGTAGGTAGCCTGTTCTATGATTTCTTTGGTCCGAACACCATGAAATCTGATATTTCCATTTCAGTATCTGAACT
GGGTTCTCTGCTGGATCACAGCGGTCCACACAAAGAAGCAGAACAGTATATCGCTCGCGTCTTTAACGCAGACCGCAGCT
ACATGGTGACTAACGGTACTTCCACTGCGAACAAAATTGTCGGTATGTACTCTGCTCCGGCAGGCAGCACCATTCTGATT
GACCGTAACTGCCACAAATCGTTGACCCATCTGATGATGATGAGCGATGTTACGCCAATCTATTTCCGCCCGACCCGTAA
CGCTTACGGTATTCTTGGTGGTATCCCACAGAGTGAATTCCAGCACGCTACCATTGCTAAGCGCGTGAAAGAAACACCAA
ACGCGACCTGGCCGGTACATGCCGTAATTACTAACTCTACCTATGATGGTCTGCTGTACAACACCGACTTCATCAAGAAA
ACTCTGGATGTGAAATCCATCCACTTTGACTCCGCGTGGGTGCCTTACACCAACTTCTCACCGATTTACGAAGGTAAATG
CGGTATGAGCGGTGGCCGTGTAGAAGGGAAAGTGATTTACGAAACCCAGTCCACTCACAAACTGCTGGCGGCGTTCTCTC
AGGCTTCCATGATCCACGTTAAAGGTGATGTAAACGAAGAAACCTTTAACGAAGCCTACATGATGCACACCACCACTTCT
CCGCACTACGGTATCGTGGCTTCCACTGAAACCGCGGCGGCGATGATGAAAGGTAATGCAGGTAAACGTCTGATCGACGG
TTCCATTGAACGTGCGATCAAGTTCCGTAAAGAGATCAAACGTCTGAGAACGGAATCTGATGGCTGGTTCTTTGATGTAT
GGCAGCCGGATCATATCGATACCACTGAATGCTGGCCGCTGCGTTCTGACAGCTCCTGGCACGGCTTCAAAAACATCGAT
AACGAGCATATGTATCTTGACCCGATCAAAGTCACTCTGCTGACTCCGGGGATGGAAAAAGACGGCACCATGAGCGACTT
CGGTATTCCGGCCAGCATCGTGGCGAAATACCTCGACGAACATGGCATCATTGTTGAGAAAACCGGTCCGTATAACCTGC
TGTTCCTGTTCAGCATCGGTATCGATAAGACCAAAGCACTGAGCCTGCTGCGTGCTCTGACTGACTTCAAACGTGCGTTC
GACCTGAACCTGCGTGTGAAAAACATGCTGCCGTCTCTGTATCGTGAAGATCCTGAATTCTATGAAAACATGCGTATTCA
GGAACTGGCTCAGAATATCCACAAACTGATTGTTCACCACAATCTGCCGGATCTGATGTATCGCGCATTTGAAGTCCTGC
CGACTATGGTAATGACCCCGTATGCTGCGTTCCAGAAAGAGCTGCACGGTATGACCGAAGAAGTTTACATCGACGAAATG
GTAGGTCGTGTTAACGCCAACATGATCCTTCCGTATCCGCCGGGAGTTCCTCTGGTAATGCCGGGTGAAATGATCACCGA
AGAAAGCCGTCCGGTTCTGGAGTTCCTGCAGATGCTGTGTGAAATCGGCGCTCACTATCCGGGCTTTGAAACCGATATTC
ACGGTGCATACCGTCAGGCTGATGGTCGCTATACCGTTAAGGTATTGAAAGAAGAAAACAAAAAATAA

Upstream 100 bases:

>100_bases
ACAGCGTCTAACGCCCATTAATTAAAAGTATTTTCCGAAAGCGCCTCCTTTCATTTGTCCCATGTGTTGGGAGGGGCTTT
CTTTACCTGGAGATATTACT

Downstream 100 bases:

>100_bases
TTAGTTAGTACAAGGGAAGTGGCTTGCCACTTCCCTTTTTCGCTCGTAAGGAGAACACATGAAAACACCCTCACAGCCGC
GCGCGATATACTATATCGTG

Product: lysine decarboxylase 1

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 715; Mature: 715

Protein sequence:

>715_residues
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLY
AFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKK
TLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLIDGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSSWHGFKNID
NEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAF
DLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYIDEM
VGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENKK

Sequences:

>Translated_715_residues
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLY
AFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKK
TLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLIDGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSSWHGFKNID
NEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAF
DLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYIDEM
VGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENKK
>Mature_715_residues
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLY
AFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKK
TLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLIDGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSSWHGFKNID
NEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAF
DLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYIDEM
VGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENKK

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=715, Percent_Identity=99.020979020979, Blast_Score=1489, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=69.0140845070423, Blast_Score=1084, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=740, Percent_Identity=36.0810810810811, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI87082193, Length=619, Percent_Identity=33.9256865912762, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1786909, Length=625, Percent_Identity=33.12, Blast_Score=308, Evalue=7e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 81261; Mature: 81261

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00703 OKR_DC_1 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWD
CCCEEEEHHCCCEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCEEEEEEEECC
KYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQT
CCCHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEEEEEEEEHHHHHHCCHHHHHHHHHHH
TDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDI
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
SISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
EEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIY
EEEECCCCCCEEEEHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNA
ECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEEECCCCCCEEEECCHHHHHHHCCCC
GKRLIDGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSSWHGFKNID
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYIDEMVGRVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENKK
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWD
CCCEEEEHHCCCEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCEEEEEEEECC
KYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAADDIANKIKQT
CCCHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEEEEEEEEHHHHHHCCHHHHHHHHHHH
TDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDI
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
SISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
EEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIY
EEEECCCCCCEEEEHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNA
ECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEEECCCCCCEEEECCHHHHHHHCCCC
GKRLIDGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSSWHGFKNID
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYIDEMVGRVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENKK
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]