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The map label for this gene is yebK [H]

Identifier: 218548586

GI number: 218548586

Start: 1260966

End: 1261835

Strand: Reverse

Name: yebK [H]

Synonym: EFER_1219

Alternate gene names: 218548586

Gene position: 1261835-1260966 (Counterclockwise)

Preceding gene: 218548590

Following gene: 218548585

Centisome position: 27.5

GC content: 48.51

Gene sequence:

>870_bases
ATGAACATGCTGGAAAAAGTCCAGGCTCAACTGGAACATTTGAGCAAATCCGAACGTAAAGTCGCTGACGTGATCCTCGC
CTCGCCTGACCGGGCTATTCACTCAAGTATCGCTGCACTGGCGCTGGAAGCGAATGTCAGCGAACCAACGGTGAATCGTT
TTTGCCGCAGCATGGACACTCGTGGCTTTCCTGATTTTAAACTGCATTTAGCACAAAGTCTGGCGAATGGAACGCTCTAT
GTTAATCATAATGTGAATGAAGATGACAGCGTAGAGTCTTATACACGGAAAATTTTCGAATCGGCGATGGCAAGCCTGGA
CCATGTTCGCCAGTCGCTGGATAACACGGCAATCAACCGCGCCGTTGATCTTCTCACTCAGGCAAAGAAAATTGCCTTTT
TTGGCCTCGGTTCATCTGCAGCTGTTGCGCACGATGCTATGAATAAATTTTTCCGCTTTAACGTTCCAGTCATCTACTCT
GATGACATCGTATTGCAGCGGATGAGCTGCATGAACTGTAATGACGATGATGTCGTAGTGCTGATTTCCCACACTGGCAG
AACCAAAAATGTGGTTGAACTGGCGCAACTGGCTCGCGAAAACGATGCCATGGTCATCGCGATTACTTCTCCCGGCACGC
CTCTGGCCCTGGAAGCTACTCTGGCAATAACCCTGGATGTACCGGAAGATACTGACATTTATATGCCCATGGTCTCTCGA
CTTGCACAGCTGACCGTGATAGATGTGCTGGCAACCGGATTTACTTTGCGCCGTGGCGCGAAATTCAGAGATAACTTGAA
GCGTGTCAAGGAAGCACTTAAGGAATCGCGTTTTGATAAGGGACTTCTTATCAAGGGTGATGATCGCTAA

Upstream 100 bases:

>100_bases
GAAAAAAAACAACACCTCTTTATCCTTTTTTGCCCCTGCTACTGTGATGGAGGGGTAATATCTACAGCAATCTTCTTTCA
CCCTTGAGTCTTTCTACATC

Downstream 100 bases:

>100_bases
AAGCAATAATAATGTTCTAACCTTTTCGTCATCCGGCGTGTTCATTTACCCCACGTGAAGTTGGGGAACACCCGGATCAA
TATTCACGCAACACCTAGTT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNMLEKVQAQLEHLSKSERKVADVILASPDRAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTLY
VNHNVNEDDSVESYTRKIFESAMASLDHVRQSLDNTAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYS
DDIVLQRMSCMNCNDDDVVVLISHTGRTKNVVELAQLARENDAMVIAITSPGTPLALEATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGLLIKGDDR

Sequences:

>Translated_289_residues
MNMLEKVQAQLEHLSKSERKVADVILASPDRAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTLY
VNHNVNEDDSVESYTRKIFESAMASLDHVRQSLDNTAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYS
DDIVLQRMSCMNCNDDDVVVLISHTGRTKNVVELAQLARENDAMVIAITSPGTPLALEATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGLLIKGDDR
>Mature_289_residues
MNMLEKVQAQLEHLSKSERKVADVILASPDRAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTLY
VNHNVNEDDSVESYTRKIFESAMASLDHVRQSLDNTAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYS
DDIVLQRMSCMNCNDDDVVVLISHTGRTKNVVELAQLARENDAMVIAITSPGTPLALEATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGLLIKGDDR

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=289, Percent_Identity=92.0415224913495, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1788767, Length=264, Percent_Identity=27.6515151515151, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082130, Length=222, Percent_Identity=27.027027027027, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=24.1666666666667, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32010; Mature: 32010

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLEKVQAQLEHLSKSERKVADVILASPDRAIHSSIAALALEANVSEPTVNRFCRSMDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RGFPDFKLHLAQSLANGTLYVNHNVNEDDSVESYTRKIFESAMASLDHVRQSLDNTAINR
CCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYSDDIVLQRMSCMNCNDDDVVV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKNVVELAQLARENDAMVIAITSPGTPLALEATLAITLDVPEDTDIYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGLLIKGDDR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCC
>Mature Secondary Structure
MNMLEKVQAQLEHLSKSERKVADVILASPDRAIHSSIAALALEANVSEPTVNRFCRSMDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RGFPDFKLHLAQSLANGTLYVNHNVNEDDSVESYTRKIFESAMASLDHVRQSLDNTAINR
CCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVIYSDDIVLQRMSCMNCNDDDVVV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKNVVELAQLARENDAMVIAITSPGTPLALEATLAITLDVPEDTDIYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKGLLIKGDDR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]