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The map label for this gene is uvrY [H]

Identifier: 218548549

GI number: 218548549

Start: 1219146

End: 1219802

Strand: Direct

Name: uvrY [H]

Synonym: EFER_1180

Alternate gene names: 218548549

Gene position: 1219146-1219802 (Clockwise)

Preceding gene: 218548547

Following gene: 218548550

Centisome position: 26.57

GC content: 49.92

Gene sequence:

>657_bases
TTGATCAACGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTTGTCGGTGAGGCATGTTGCGGCGAAGACGCCGTTAAATGGTGCCGTTCTAACACCGTCGATGTGGTGTTGATGG
ACATGAGTATGCCTGGTATCGGTGGCCTTGAAGCAACGCGCAAAATCGCGCGCTCTTCAGCAGATATCAAAGTGATTATG
TTGACCGTTCACACTGAAAACCCGTTGCCTGCAAAAGTCATGCAGGCGGGTGCGGCAGGTTACCTGAGCAAAGGAGCAGC
CCCCCAGGAAGTGGTTAGCGCGATTCGTTCTGTTTATTCAGGGCAGCGGTATATTGCGTCGGATATTGCGCAGCAGATGG
CGCTCAGCCAGATCGAGCCGGAAAAAACCGAAACGCCTTTTGCCAGTTTGTCCGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAAGGCCAGAAGGTTAATGAGATCTCAGAACAACTGAATCTCAGCCCGAAAACGGTGAACAGTTATCGCTACCG
TATGTTCAGTAAACTAAACATTCACGGTGATGTTGAACTGACCCACCTGGCGATTCGCCATGGCCTGTGTAATGCGGAGA
CATTATCAAGCCAGTGA

Upstream 100 bases:

>100_bases
CTAATGACGGACATTTTAACATTTCAAAGTTGGGGTAAAACCCGCTAATATAGGGACGACATAATATCAGTAGCGTTATC
CCTATTCTGGAGATATTCCT

Downstream 100 bases:

>100_bases
GTGATCAGTTTGATGCCAAAGCGTTTTTAAAAACCGTTACCAGTCAGCCCGGCGTCTATCGTATGTATGATGCCGGCGGT
ACGGTCATTTATGTGGGTAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRSNTVDVVLMDMSMPGIGGLEATRKIARSSADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Sequences:

>Translated_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRSNTVDVVLMDMSMPGIGGLEATRKIARSSADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
>Mature_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRSNTVDVVLMDMSMPGIGGLEATRKIARSSADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=96.7889908256881, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=36.318407960199, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=31.5533980582524, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=27.3170731707317, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=26.5700483091787, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23925; Mature: 23925

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRSNTVDVVLMDMSMPGI
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSSADIKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPEKTETPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRSNTVDVVLMDMSMPGI
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSSADIKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPEKTETPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]