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The map label for this gene is elaC [H]

Identifier: 218548281

GI number: 218548281

Start: 916717

End: 917679

Strand: Reverse

Name: elaC [H]

Synonym: EFER_0900

Alternate gene names: 218548281

Gene position: 917679-916717 (Counterclockwise)

Preceding gene: 218548291

Following gene: 218548280

Centisome position: 20.0

GC content: 48.81

Gene sequence:

>963_bases
TTGTTTTATACTAGCCGCAATACTTTTGAAAAATGTGATGGTCTCATGGAATTAATTTTTTTAGGTACGTCTGCGGGTGT
ACCGACCCGGACTCGAAATGTCACAGCGATATTACTCAACCTGCAACATCCAACCCAGGCCGGCCTGTGGTTATTTGACT
GTGGTGAAGGTACGCAACATCAATTGCTAAGCACAAGTTATAATCCCGGCAAACTGGATCGGATTTTTATCAGCCACTTA
CATGGCGATCATCTTTTTGGCTTGCCGGGTTTGCTTTGCAGCCGCTCTATGGCAGGGAGTATGCAACCGCTCACTATTTA
CGGACCAAAAGGTATTCAGGAATTTGTAGAAACCACCCTACGGTTGAGCAGTTCCTGGACGGATTATCCGCTGGACGTCA
TTGAAATCAGTGCAGGAGAGATCCTGGATGATGGCCTGCGCAAGGTGACCGCGTACCCGATGGAACACCCACTGGAGTGT
TATGGTTTTCGCATTGAAGAGCATGAAAAACCTGGCGCATTGGATGCTAAAGGGTTAAAAGCGGCAGGCGTGCAGCCCGG
TCCCCTGTTTCAGGATTTAAAAGCGGGCAAAACAGTAACCCTGGAAGACGGCAGGCAAATTAACGGTGCTGATTATTTAG
CGCCAGCAACGCCAGGAAAAGTGCTCGCTATTTTTGGTGACACAGCACCCTGTGATAACGCGCTTGAACTTGCCCGACAC
GCAGACGTGATGATCCATGAAGCAACCCTGGATATGTCGATGGAAGCTAAAGCTAACAGCCGGGGGCACAGTTCGACGTG
TCAGGCAGCAACATTGGCGCGAGAAGCCGGTGTAAGTAAATTGATTATTACCCATATCAGCTCACGTTATGACGATAAAG
GCTGTCAGCGTATGTTACAGGAGTGCCGCGATATTTTCCCGGCAACCGATCTGGCTCACGATTACGCAGTTTTTAGCGTT
TAA

Upstream 100 bases:

>100_bases
ACTGCACAACGCAGTTGTAATAAAGCATAAAGCTGAGAGACGTTGAGTTCGGAATTATGCAGATCTTGCCAGTCAATCAT
CGGGCGCTCCTTTGTGATGT

Downstream 100 bases:

>100_bases
CGCTGTATTTTTTGTCCTCACTGCCGATAACTGTTTTGTTACAGGCTTTCGCTGAGGACAGGATGGACAATTTCCAGAAA
GATATTGATGACAGAGCCAA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MFYTSRNTFEKCDGLMELIFLGTSAGVPTRTRNVTAILLNLQHPTQAGLWLFDCGEGTQHQLLSTSYNPGKLDRIFISHL
HGDHLFGLPGLLCSRSMAGSMQPLTIYGPKGIQEFVETTLRLSSSWTDYPLDVIEISAGEILDDGLRKVTAYPMEHPLEC
YGFRIEEHEKPGALDAKGLKAAGVQPGPLFQDLKAGKTVTLEDGRQINGADYLAPATPGKVLAIFGDTAPCDNALELARH
ADVMIHEATLDMSMEAKANSRGHSSTCQAATLAREAGVSKLIITHISSRYDDKGCQRMLQECRDIFPATDLAHDYAVFSV

Sequences:

>Translated_320_residues
MFYTSRNTFEKCDGLMELIFLGTSAGVPTRTRNVTAILLNLQHPTQAGLWLFDCGEGTQHQLLSTSYNPGKLDRIFISHL
HGDHLFGLPGLLCSRSMAGSMQPLTIYGPKGIQEFVETTLRLSSSWTDYPLDVIEISAGEILDDGLRKVTAYPMEHPLEC
YGFRIEEHEKPGALDAKGLKAAGVQPGPLFQDLKAGKTVTLEDGRQINGADYLAPATPGKVLAIFGDTAPCDNALELARH
ADVMIHEATLDMSMEAKANSRGHSSTCQAATLAREAGVSKLIITHISSRYDDKGCQRMLQECRDIFPATDLAHDYAVFSV
>Mature_320_residues
MFYTSRNTFEKCDGLMELIFLGTSAGVPTRTRNVTAILLNLQHPTQAGLWLFDCGEGTQHQLLSTSYNPGKLDRIFISHL
HGDHLFGLPGLLCSRSMAGSMQPLTIYGPKGIQEFVETTLRLSSSWTDYPLDVIEISAGEILDDGLRKVTAYPMEHPLEC
YGFRIEEHEKPGALDAKGLKAAGVQPGPLFQDLKAGKTVTLEDGRQINGADYLAPATPGKVLAIFGDTAPCDNALELARH
ADVMIHEATLDMSMEAKANSRGHSSTCQAATLAREAGVSKLIITHISSRYDDKGCQRMLQECRDIFPATDLAHDYAVFSV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=361, Percent_Identity=34.0720221606648, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI145553959, Length=291, Percent_Identity=27.4914089347079, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI260166619, Length=291, Percent_Identity=27.4914089347079, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI260166622, Length=291, Percent_Identity=27.4914089347079, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=83.2786885245902, Blast_Score=546, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71985808, Length=291, Percent_Identity=26.8041237113402, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985814, Length=291, Percent_Identity=26.8041237113402, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24652403, Length=294, Percent_Identity=29.5918367346939, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471
- InterPro:   IPR013469 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 34943; Mature: 34943

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYTSRNTFEKCDGLMELIFLGTSAGVPTRTRNVTAILLNLQHPTQAGLWLFDCGEGTQH
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHH
QLLSTSYNPGKLDRIFISHLHGDHLFGLPGLLCSRSMAGSMQPLTIYGPKGIQEFVETTL
HHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHH
RLSSSWTDYPLDVIEISAGEILDDGLRKVTAYPMEHPLECYGFRIEEHEKPGALDAKGLK
HHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHCEEEECCCCCCCCCCCCCE
AAGVQPGPLFQDLKAGKTVTLEDGRQINGADYLAPATPGKVLAIFGDTAPCDNALELARH
ECCCCCCCHHHHHHCCCEEEECCCCEECCCCEECCCCCCCEEEEECCCCCCHHHHHHHHH
ADVMIHEATLDMSMEAKANSRGHSSTCQAATLAREAGVSKLIITHISSRYDDKGCQRMLQ
HCEEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
ECRDIFPATDLAHDYAVFSV
HHHHHCCCHHHCCCEEEECC
>Mature Secondary Structure
MFYTSRNTFEKCDGLMELIFLGTSAGVPTRTRNVTAILLNLQHPTQAGLWLFDCGEGTQH
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHH
QLLSTSYNPGKLDRIFISHLHGDHLFGLPGLLCSRSMAGSMQPLTIYGPKGIQEFVETTL
HHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHH
RLSSSWTDYPLDVIEISAGEILDDGLRKVTAYPMEHPLECYGFRIEEHEKPGALDAKGLK
HHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHCEEEECCCCCCCCCCCCCE
AAGVQPGPLFQDLKAGKTVTLEDGRQINGADYLAPATPGKVLAIFGDTAPCDNALELARH
ECCCCCCCHHHHHHCCCEEEECCCCEECCCCEECCCCCCCEEEEECCCCCCHHHHHHHHH
ADVMIHEATLDMSMEAKANSRGHSSTCQAATLAREAGVSKLIITHISSRYDDKGCQRMLQ
HCEEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
ECRDIFPATDLAHDYAVFSV
HHHHHCCCHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA