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The map label for this gene is treR [H]

Identifier: 218235459

GI number: 218235459

Start: 656437

End: 657147

Strand: Direct

Name: treR [H]

Synonym: BCB4264_A0666

Alternate gene names: 218235459

Gene position: 656437-657147 (Clockwise)

Preceding gene: 218230897

Following gene: 218234137

Centisome position: 12.11

GC content: 33.05

Gene sequence:

>711_bases
ATGATGAGTAAGTATGAACAAATTTATACAGAAATCAGTAAATCTATTGATAATAAACAATTAAAAGAGGGATGCAAAAT
CCCATCAGAAACAGAATTAATGAAGCAGTATGAGGCAAGCCGAGGCACGGTAAGAAAAGCTGTAGATTTACTGCAAGAGC
GTGGATATGTGCAAAAAATTCATGGGAAAGGTGTTTTTGTTTTAAAGCGAAAAAATATTGAATTTAATTTTGGCGGTATT
GTAAGTTTCCAAGAAGAAAATGAACGTTTAGGACGTCATTGTATTACGGAAGTTGTGGAAATGGACAAAGAAAAAGCCAC
AAAAGACATTGCGAAATTATTAAATGTAAAAGAAAAAACAGAGATTGACCATATTAAACGTGTACGAAATATTGATGGAG
AAAAAGTAATTTTAGATATAAATCATTTTGTATCTGAGTTTATTCCAGGATTAACGAAAGAAATTGCAACTGCATCGATT
TATAAATACATCGAGAAAGAGCTTGGGCTACATATTAGTTATTCGCAGAGGGTAATAGAAGTACAGCCATGTACAGAGGA
TGACAGAAAGTATTTAGATTTAAATGGAACAGACTATGTTGTCGTTGTGAAAAACTTTACACATTTGTATGATGGAAGTC
AGTTTGAATATACAGAATCACGCCACCGTTTAGATATTTTTCACTTTTCGGATGTGGCACGCAGGAAGTAA

Upstream 100 bases:

>100_bases
CTATATTTTTCTTGTACTGGAAAATAAGTGAGAGATTGGCAGAAGAGTGAAGCATGTTATAATACATATAGAATTAGAAG
GTGACAAGGGGCTATTGTAG

Downstream 100 bases:

>100_bases
AGAGGTGGAACAAAATATTGTTTCATCTCTTTTTTTTATAAAAAAAACACAAACTCGTATATACGAGTGTTGACTAACTT
ATATATACGAGTTAATATGT

Product: trehalose operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MMSKYEQIYTEISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKIHGKGVFVLKRKNIEFNFGGI
VSFQEENERLGRHCITEVVEMDKEKATKDIAKLLNVKEKTEIDHIKRVRNIDGEKVILDINHFVSEFIPGLTKEIATASI
YKYIEKELGLHISYSQRVIEVQPCTEDDRKYLDLNGTDYVVVVKNFTHLYDGSQFEYTESRHRLDIFHFSDVARRK

Sequences:

>Translated_236_residues
MMSKYEQIYTEISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKIHGKGVFVLKRKNIEFNFGGI
VSFQEENERLGRHCITEVVEMDKEKATKDIAKLLNVKEKTEIDHIKRVRNIDGEKVILDINHFVSEFIPGLTKEIATASI
YKYIEKELGLHISYSQRVIEVQPCTEDDRKYLDLNGTDYVVVVKNFTHLYDGSQFEYTESRHRLDIFHFSDVARRK
>Mature_236_residues
MMSKYEQIYTEISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKIHGKGVFVLKRKNIEFNFGGI
VSFQEENERLGRHCITEVVEMDKEKATKDIAKLLNVKEKTEIDHIKRVRNIDGEKVILDINHFVSEFIPGLTKEIATASI
YKYIEKELGLHISYSQRVIEVQPCTEDDRKYLDLNGTDYVVVVKNFTHLYDGSQFEYTESRHRLDIFHFSDVARRK

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=236, Percent_Identity=28.8135593220339, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790540, Length=235, Percent_Identity=24.6808510638298, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790118, Length=168, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082252, Length=172, Percent_Identity=26.1627906976744, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27573; Mature: 27573

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSKYEQIYTEISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKI
CCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
HGKGVFVLKRKNIEFNFGGIVSFQEENERLGRHCITEVVEMDKEKATKDIAKLLNVKEKT
CCCCEEEEEECCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EIDHIKRVRNIDGEKVILDINHFVSEFIPGLTKEIATASIYKYIEKELGLHISYSQRVIE
HHHHHHHHHCCCCCEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCEEEECCCCEEE
VQPCTEDDRKYLDLNGTDYVVVVKNFTHLYDGSQFEYTESRHRLDIFHFSDVARRK
EECCCCCCCEEEECCCCCEEEEEECCHHHHCCCCCCCCCCCCEEEEEEHHHHHHCC
>Mature Secondary Structure
MMSKYEQIYTEISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKI
CCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
HGKGVFVLKRKNIEFNFGGIVSFQEENERLGRHCITEVVEMDKEKATKDIAKLLNVKEKT
CCCCEEEEEECCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EIDHIKRVRNIDGEKVILDINHFVSEFIPGLTKEIATASIYKYIEKELGLHISYSQRVIE
HHHHHHHHHCCCCCEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCEEEECCCCEEE
VQPCTEDDRKYLDLNGTDYVVVVKNFTHLYDGSQFEYTESRHRLDIFHFSDVARRK
EECCCCCCCEEEECCCCCEEEEEECCHHHHCCCCCCCCCCCCEEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]