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The map label for this gene is nupC [H]

Identifier: 218234991

GI number: 218234991

Start: 630024

End: 631202

Strand: Reverse

Name: nupC [H]

Synonym: BCB4264_A0644

Alternate gene names: 218234991

Gene position: 631202-630024 (Counterclockwise)

Preceding gene: 218232487

Following gene: 218235568

Centisome position: 11.65

GC content: 34.1

Gene sequence:

>1179_bases
ATGAAATTCATTACTTTTTTCGTCGGACTAATTGTTGTTTTCTTGCTCGCTTATATTGCTAGCAATAATAAGAAGCATAT
TAAATTTAAACCAATTTTTATCATGCTTATTATACAGTTAATTTTAACCTATTTACTATTAAATACAGAAATCGGCCTCA
TACTTATTAGAATCATTTCCAGTTTGTTTACCAAGCTACTCGAGTATGCTGCTGATGGAATAAATTTCGTATTTGGTGGT
CTTGCAAATAAAGGTGAAATGCCATTTTTCCTTACTGTATTATTACCAATCGTCTTTATTTCTGTTTTAATCGGTATATT
ACAACATTTCAAAATATTACCATTTTTTATTCGTTGGATCGGGTACTTTCTTAGTAAAATAAATGGTCTTGGTAAATTAG
AATCTTACAACGCTATCGCCTCTGCCATTGTCGGCCAATCAGAAGTTTTTATTACAGTGAAAAAACAATTAACTCAAATT
CCAAAACACCGTCTTTATACACTTTGTGCCTCTGCTATGTCAACCGTATCTATGTCTATCGTAGGTGCCTATATGACAAT
GATTGAACCTAAATATGTAGTAACTGCACTCGTTCTCAATTTATTTAGCGGTTTTATTATCATACTCATCATTAACCCTT
ACGACGTTAAAGATGACGAAGATATTTTAGAAATCAAAGGTGAAAAACAAAGCTTTTTTGAAATGCTTGGAGAATACATT
CTTGATGGTTTTCGTGTAGCCATTGTTGTCGGCGCTATGCTCATCGGATTCGTCGCATTAATTAGTTGTATTAATGACCT
GTTCCTCATTATATTCGGTATTACGTTCCAACAATTAATCGGCTATGTATTTGCACCTATCGCATTCCTTATCGGTGTAC
CCAGTTCTGAAATTGTCGCAGCTGGCAGCATTATGGCAACGAAGCTTGTAACGAATGAATTTGTCGCAATGATGGACCTT
AGTAAAATTTCTAATAGCCTTTCTCCCCGTACAGTTGGTATTATTTCTGTTTTCCTTGTATCTTTTGCCAATTTTTCTTC
CATTGGTATTATTTCAGGTGCGGTAAAAGGACTAAACGAAGAACAAGGAAACGTTGTTGCGAGGTTTGGCCTTAAATTAC
TATATGGAGCTACTCTCGTTAGTATTTTATCTGCAATTATCGTAAGCATTATGTTGTAA

Upstream 100 bases:

>100_bases
TATATTCATGCTCTCTCTATTCCTTTCTTTACCAAAGATGCATATTCTCCCTTGAAATGAAAAACATATATAGCAGAATA
TCTCTTTTAGGGGGCTTACC

Downstream 100 bases:

>100_bases
TTAGGTAAAATTTTATCATTTTCTTATCCCTATCTTTTGTATACAATAACGAATAGGTGTCTTATAAATAATCAAGACAT
CTATTTTTTATACATGTACA

Product: nucleoside transporter, NupC family

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKFITFFVGLIVVFLLAYIASNNKKHIKFKPIFIMLIIQLILTYLLLNTEIGLILIRIISSLFTKLLEYAADGINFVFGG
LANKGEMPFFLTVLLPIVFISVLIGILQHFKILPFFIRWIGYFLSKINGLGKLESYNAIASAIVGQSEVFITVKKQLTQI
PKHRLYTLCASAMSTVSMSIVGAYMTMIEPKYVVTALVLNLFSGFIIILIINPYDVKDDEDILEIKGEKQSFFEMLGEYI
LDGFRVAIVVGAMLIGFVALISCINDLFLIIFGITFQQLIGYVFAPIAFLIGVPSSEIVAAGSIMATKLVTNEFVAMMDL
SKISNSLSPRTVGIISVFLVSFANFSSIGIISGAVKGLNEEQGNVVARFGLKLLYGATLVSILSAIIVSIML

Sequences:

>Translated_392_residues
MKFITFFVGLIVVFLLAYIASNNKKHIKFKPIFIMLIIQLILTYLLLNTEIGLILIRIISSLFTKLLEYAADGINFVFGG
LANKGEMPFFLTVLLPIVFISVLIGILQHFKILPFFIRWIGYFLSKINGLGKLESYNAIASAIVGQSEVFITVKKQLTQI
PKHRLYTLCASAMSTVSMSIVGAYMTMIEPKYVVTALVLNLFSGFIIILIINPYDVKDDEDILEIKGEKQSFFEMLGEYI
LDGFRVAIVVGAMLIGFVALISCINDLFLIIFGITFQQLIGYVFAPIAFLIGVPSSEIVAAGSIMATKLVTNEFVAMMDL
SKISNSLSPRTVGIISVFLVSFANFSSIGIISGAVKGLNEEQGNVVARFGLKLLYGATLVSILSAIIVSIML
>Mature_392_residues
MKFITFFVGLIVVFLLAYIASNNKKHIKFKPIFIMLIIQLILTYLLLNTEIGLILIRIISSLFTKLLEYAADGINFVFGG
LANKGEMPFFLTVLLPIVFISVLIGILQHFKILPFFIRWIGYFLSKINGLGKLESYNAIASAIVGQSEVFITVKKQLTQI
PKHRLYTLCASAMSTVSMSIVGAYMTMIEPKYVVTALVLNLFSGFIIILIINPYDVKDDEDILEIKGEKQSFFEMLGEYI
LDGFRVAIVVGAMLIGFVALISCINDLFLIIFGITFQQLIGYVFAPIAFLIGVPSSEIVAAGSIMATKLVTNEFVAMMDL
SKISNSLSPRTVGIISVFLVSFANFSSIGIISGAVKGLNEEQGNVVARFGLKLLYGATLVSILSAIIVSIML

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=411, Percent_Identity=24.5742092457421, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI11545853, Length=413, Percent_Identity=25.4237288135593, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI227116277, Length=412, Percent_Identity=22.5728155339806, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1788737, Length=398, Percent_Identity=59.7989949748744, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788485, Length=408, Percent_Identity=26.7156862745098, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788488, Length=409, Percent_Identity=27.8728606356968, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17560276, Length=409, Percent_Identity=24.6943765281174, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71991794, Length=405, Percent_Identity=24.1975308641975, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45552517, Length=393, Percent_Identity=23.4096692111959, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921868, Length=393, Percent_Identity=23.4096692111959, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45552519, Length=393, Percent_Identity=23.4096692111959, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360430, Length=358, Percent_Identity=23.7430167597765, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 43117; Mature: 43117

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFITFFVGLIVVFLLAYIASNNKKHIKFKPIFIMLIIQLILTYLLLNTEIGLILIRIIS
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLFTKLLEYAADGINFVFGGLANKGEMPFFLTVLLPIVFISVLIGILQHFKILPFFIRWI
HHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYFLSKINGLGKLESYNAIASAIVGQSEVFITVKKQLTQIPKHRLYTLCASAMSTVSMSI
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAYMTMIEPKYVVTALVLNLFSGFIIILIINPYDVKDDEDILEIKGEKQSFFEMLGEYI
HHHHHHHHCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHH
LDGFRVAIVVGAMLIGFVALISCINDLFLIIFGITFQQLIGYVFAPIAFLIGVPSSEIVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AGSIMATKLVTNEFVAMMDLSKISNSLSPRTVGIISVFLVSFANFSSIGIISGAVKGLNE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
EQGNVVARFGLKLLYGATLVSILSAIIVSIML
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFITFFVGLIVVFLLAYIASNNKKHIKFKPIFIMLIIQLILTYLLLNTEIGLILIRIIS
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLFTKLLEYAADGINFVFGGLANKGEMPFFLTVLLPIVFISVLIGILQHFKILPFFIRWI
HHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYFLSKINGLGKLESYNAIASAIVGQSEVFITVKKQLTQIPKHRLYTLCASAMSTVSMSI
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAYMTMIEPKYVVTALVLNLFSGFIIILIINPYDVKDDEDILEIKGEKQSFFEMLGEYI
HHHHHHHHCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHH
LDGFRVAIVVGAMLIGFVALISCINDLFLIIFGITFQQLIGYVFAPIAFLIGVPSSEIVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AGSIMATKLVTNEFVAMMDLSKISNSLSPRTVGIISVFLVSFANFSSIGIISGAVKGLNE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
EQGNVVARFGLKLLYGATLVSILSAIIVSIML
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]