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The map label for this gene is cls1 [H]

Identifier: 218233854

GI number: 218233854

Start: 650274

End: 651803

Strand: Reverse

Name: cls1 [H]

Synonym: BCB4264_A0662

Alternate gene names: 218233854

Gene position: 651803-650274 (Counterclockwise)

Preceding gene: 218236039

Following gene: 218234349

Centisome position: 12.03

GC content: 33.92

Gene sequence:

>1530_bases
ATGAAGAAGCCTATCGTTCAATTACTATTAATATTTACAATTGTATCTATCGTTCTGTTCCTATTAAATACATCTTATAT
CTCGTTATATACATTTGTCGGTGCTCTATGGTCCATCACAATCGTAGGAATTTCATTCGTTATTTTTATAGAAAATAGAT
CTCCACAAAGTACATTAGCATGGTTTTTAGTATTAGCACTTCTTCCTATTATAGGTGTGCTTTTATACGCTATTTTCGGA
CGCAGCCGCTGGAGAAGAAAAAAACATCTCCATCGTTCAGAAGAACAAAGAAAATTATTCCGTGAAATATTAGAAGGAAG
AAGACTAGAGTTATTACTCACAGTCCCACTAAATGAACGTTCCATACATTTAACAGAAGTCATACAAAAATTTGGAGGCG
GTCCTGCCGCAGATAGAACAACTACAAAACTTTTAACAAACGGAGATCAAACATTTTCAGAAATTTTGCGAGCTATAGAG
CAAGCAAAACATCATATACATATTCAATACTACATTTATAAATCTGATGAAATTGGTACAAAAGTTCGAGATGCTTTAAT
ACAAAAAGCAAAAGATGGTGTTATTGTACGATTCCTTTATGATGGCCTTGGAAGTAATACGTTAAGAAGACGATTTTTAC
AACCTATGAAAGAAGCTGGGATTGAAATTGTAGAATTTGACCCTATTTTTTCAGCTTGGTTACTTGAAACTGTCAATTAT
CGTAACCATCGAAAAATTGTTATTGTAGATGGCGAAATTGGTTTTACCGGAGGACTCAATGTCGGTGATGAATATCTTGG
CCGTTCAAAGAAATTTCCTGTTTGGCGTGATAGTCATTTAAAAATAGAAGGAAAAGCATTATATAAATTACAAGCAATCT
TTCTAGAAGACTGGCTCTATGCCTCTAGTGGTTTAAATACTTATTCCTGGGATCAATTCATGAATAGACAATACTTCCCA
GGTAAAGAGATTTCAAATGCAGAAGGTGCTGTTCAAATCGTAGCAAGCGGACCAAGCTCCGATGATAAAAGTATTCGTAA
TACATTATTAGCTGTTATGGGCTCTGCAAAAAAATCCATTTGGATTGCTACACCCTACTTTATTCCAGATCAAGAAACTT
TAACATTATTACGCTTAAGTGCAATTGCCGGAATAGATGTACGGATTTTATATCCAGGTAAAAGTGATAGCATCATTAGT
GATCAAGCATCTCAATCCTATTTCACTCCGCTTTTAAAAGCTGGTGCTTCTATTTACAGTTATAAAGATGGTTTTATGCA
TGCAAAAATTGTACTCGTTGATGATACAATTGCAACTATTGGAACAGCGAACATGGATGTACGTAGCTTTGAATTGAATT
ACGAAATTATTAGCGTACTTTATGAATCAAAAACAGTTCACGATATTAAACGTGATTTTGAAGAAGATTTTAAACATTCG
ACTGAAATTAAATGGAACTCTTTCCAAAAAAGAAGTATAAAAAAACGCATATTGGAGTCTTTCATGAGGCTCATTTCTCC
TTTACTGTAG

Upstream 100 bases:

>100_bases
ATTTTGTAAAAAAAGCAAAACACCTTATAATAAAGATGTCATATTACATCTTCTATTTAAGAAGTCTATATTGAAAAAAG
ATTAGGGGAATTATATAGAA

Downstream 100 bases:

>100_bases
GCAATCAACTTCATCTTGATTGCTTTTTCTTTTCCCTTTATCCTCCTTCCTTTTCTTTGCATACCATATTAAAACAAGTT
ATCATAAGATGTATTACTTT

Product: cardiolipin synthetase

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGALWSITIVGISFVIFIENRSPQSTLAWFLVLALLPIIGVLLYAIFG
RSRWRRKKHLHRSEEQRKLFREILEGRRLELLLTVPLNERSIHLTEVIQKFGGGPAADRTTTKLLTNGDQTFSEILRAIE
QAKHHIHIQYYIYKSDEIGTKVRDALIQKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKIEGKALYKLQAIFLEDWLYASSGLNTYSWDQFMNRQYFP
GKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSIWIATPYFIPDQETLTLLRLSAIAGIDVRILYPGKSDSIIS
DQASQSYFTPLLKAGASIYSYKDGFMHAKIVLVDDTIATIGTANMDVRSFELNYEIISVLYESKTVHDIKRDFEEDFKHS
TEIKWNSFQKRSIKKRILESFMRLISPLL

Sequences:

>Translated_509_residues
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGALWSITIVGISFVIFIENRSPQSTLAWFLVLALLPIIGVLLYAIFG
RSRWRRKKHLHRSEEQRKLFREILEGRRLELLLTVPLNERSIHLTEVIQKFGGGPAADRTTTKLLTNGDQTFSEILRAIE
QAKHHIHIQYYIYKSDEIGTKVRDALIQKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKIEGKALYKLQAIFLEDWLYASSGLNTYSWDQFMNRQYFP
GKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSIWIATPYFIPDQETLTLLRLSAIAGIDVRILYPGKSDSIIS
DQASQSYFTPLLKAGASIYSYKDGFMHAKIVLVDDTIATIGTANMDVRSFELNYEIISVLYESKTVHDIKRDFEEDFKHS
TEIKWNSFQKRSIKKRILESFMRLISPLL
>Mature_509_residues
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGALWSITIVGISFVIFIENRSPQSTLAWFLVLALLPIIGVLLYAIFG
RSRWRRKKHLHRSEEQRKLFREILEGRRLELLLTVPLNERSIHLTEVIQKFGGGPAADRTTTKLLTNGDQTFSEILRAIE
QAKHHIHIQYYIYKSDEIGTKVRDALIQKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKIEGKALYKLQAIFLEDWLYASSGLNTYSWDQFMNRQYFP
GKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSIWIATPYFIPDQETLTLLRLSAIAGIDVRILYPGKSDSIIS
DQASQSYFTPLLKAGASIYSYKDGFMHAKIVLVDDTIATIGTANMDVRSFELNYEIISVLYESKTVHDIKRDFEEDFKHS
TEIKWNSFQKRSIKKRILESFMRLISPLL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=496, Percent_Identity=27.2177419354839, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1787007, Length=321, Percent_Identity=27.7258566978193, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87081826, Length=420, Percent_Identity=25.4761904761905, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 58193; Mature: 58193

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGALWSITIVGISFVIFIENRSPQSTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHH
WFLVLALLPIIGVLLYAIFGRSRWRRKKHLHRSEEQRKLFREILEGRRLELLLTVPLNER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
SIHLTEVIQKFGGGPAADRTTTKLLTNGDQTFSEILRAIEQAKHHIHIQYYIYKSDEIGT
CCHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCH
KVRDALIQKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
HHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCC
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKIEGKALYKLQAIFLEDWLY
CCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
ASSGLNTYSWDQFMNRQYFPGKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSI
HCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEE
WIATPYFIPDQETLTLLRLSAIAGIDVRILYPGKSDSIISDQASQSYFTPLLKAGASIYS
EEECCEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHEE
YKDGFMHAKIVLVDDTIATIGTANMDVRSFELNYEIISVLYESKTVHDIKRDFEEDFKHS
ECCCCEEEEEEEEECCHHHHCCCCCCEEEEECCHHHHHHHHHCHHHHHHHHHHHHHHCCC
TEIKWNSFQKRSIKKRILESFMRLISPLL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGALWSITIVGISFVIFIENRSPQSTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHH
WFLVLALLPIIGVLLYAIFGRSRWRRKKHLHRSEEQRKLFREILEGRRLELLLTVPLNER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
SIHLTEVIQKFGGGPAADRTTTKLLTNGDQTFSEILRAIEQAKHHIHIQYYIYKSDEIGT
CCHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCH
KVRDALIQKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
HHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCC
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKIEGKALYKLQAIFLEDWLY
CCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
ASSGLNTYSWDQFMNRQYFPGKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSI
HCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEE
WIATPYFIPDQETLTLLRLSAIAGIDVRILYPGKSDSIISDQASQSYFTPLLKAGASIYS
EEECCEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHEE
YKDGFMHAKIVLVDDTIATIGTANMDVRSFELNYEIISVLYESKTVHDIKRDFEEDFKHS
ECCCCEEEEEEEEECCHHHHCCCCCCEEEEECCHHHHHHHHHCHHHHHHHHHHHHHHCCC
TEIKWNSFQKRSIKKRILESFMRLISPLL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]