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The map label for this gene is ilvC

Identifier: 21672831

GI number: 21672831

Start: 630756

End: 632231

Strand: Reverse

Name: ilvC

Synonym: BUsg575

Alternate gene names: 21672831

Gene position: 632231-630756 (Counterclockwise)

Preceding gene: 21672832

Following gene: 21672830

Centisome position: 98.56

GC content: 26.83

Gene sequence:

>1476_bases
ATGAATTATTTTAATAAATTATGTTTTCGTAAAAGAATTAATGAAATCAAAAAATGTCGCTTTATGAAAGAAAACGAATT
TAAAAATGAAAATAAAATTTTAAAAAATAAAAAAATAGTTATTGTAGGTTGTGGGTCACAAGGTTTAAATCAAGCTTTAA
ATATGAGAGATTCTGGATTAAATATCTCCTTTGCACTTAAAAAAAACAGTATTTTAAGAAAAAACTCTTCTTGGTTAAAC
GCAACTAAAAATAATTTTGAAGTTAATGACTATGAATCATTAATACCAAATGCTGATTTAGTTATCAATTTAACACCAGA
TAAACAACATGAAAATGTTGTGAAAGAACTACAAAAACTGATGAAAAAAAATTCATGTTTAGGTTATTCACATGGTTTTA
ATATTGTAGAATGTGGTGAAATTATACGAAAAGATATAACAGTCGTTATGGTGGCACCAAAATGTCCTGGAACAGAAGTG
AGAGAAGAATTCAAAAGAGGATTTGGGGTACCTACGTTAATTGCGGTTCATACTGAAAATGATCCTAAAAAAATAGGATT
AGAAATTGCAAAAGCATGGGCTTTCTCAACAGGTGGGCATCGTGCAGGAGTTTTAGAATCTTCATTTATAGCTGAAGTAA
AATCAGATTTAATGGGAGAACAAACAATTTTATGTGGATTATTACAAACAGCTTCTCTAATATGTTATGAAAAATTAATT
AAAGATAAACATAATCCTTCTTATGCAGCAAAGTTAATACAATATGGTTGGGAAACAATCACAGAATCTCTTAAGCATGG
GGGTATCACACTCATGATGGATAGACTTTCTAATCCATCAAAAATCAAAGCATTTAAAATATCTAAAAAAATAAAAAAAA
TATTATCACCTCTCTTTAAAAAACATATGGACGATATTATTTCAGGTTCTTTTTCTAAAGAAATGATGATAGATTGGCAT
AATAACGATAAAAAATTATTAAATTGGCGAGAAGATACAAAAAAAACACCTTTTGAAAAAAATATTCTTTCTTACTCTGA
AAAAATATCAGAACAAGAATATTACGATCATGGAACACTAATGGTATCTATATTAAAATCAGGCATTGAATTAGCTTTTG
AAACGATGATCAACACAGGTATCATAAATGAGTCAGCCTATTACGAATCTTTACATGAATTACCATTAATTGCTAATACA
ATTGCAAGAAAGAAATTATATGAAATGAATATAGTCATTTCAGATACAGCAGAATATGGAAGCTATCTTTTTTCTGAAGC
AGCATATCCTATTTTAAAAGATTTTATTATGAGTCTTGAAAAAAATGTTTTAGGATTGTCATTACCAAATACAAAAATAG
ATAATATTGAATTATATAAAATTAATGAAGAAATTCGTAATCATCCAATTGAAATTGTTGGGAAAAAATTAAGAAAACAT
ATGAAAGAAATGAAATCAATTTGTGTTGCAAAATAA

Upstream 100 bases:

>100_bases
TAAGAAATAAAAAGAAACTATTTAATTTTTAAAAAATAAAATTTATCATCAATAACAATAAATATTAAATCAATTTTAAA
TTATTCAGGAATTACTAAAA

Downstream 100 bases:

>100_bases
ACAATAAATTCTCTAAATTTTACCTTAATTTTTTAAGAATTTTTAAAAATTAATTTTCTAATCAATCTGAAATTATTATT
TTATGTCTCTTAATTTTAAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNYFNKLCFRKRINEIKKCRFMKENEFKNENKILKNKKIVIVGCGSQGLNQALNMRDSGLNISFALKKNSILRKNSSWLN
ATKNNFEVNDYESLIPNADLVINLTPDKQHENVVKELQKLMKKNSCLGYSHGFNIVECGEIIRKDITVVMVAPKCPGTEV
REEFKRGFGVPTLIAVHTENDPKKIGLEIAKAWAFSTGGHRAGVLESSFIAEVKSDLMGEQTILCGLLQTASLICYEKLI
KDKHNPSYAAKLIQYGWETITESLKHGGITLMMDRLSNPSKIKAFKISKKIKKILSPLFKKHMDDIISGSFSKEMMIDWH
NNDKKLLNWREDTKKTPFEKNILSYSEKISEQEYYDHGTLMVSILKSGIELAFETMINTGIINESAYYESLHELPLIANT
IARKKLYEMNIVISDTAEYGSYLFSEAAYPILKDFIMSLEKNVLGLSLPNTKIDNIELYKINEEIRNHPIEIVGKKLRKH
MKEMKSICVAK

Sequences:

>Translated_491_residues
MNYFNKLCFRKRINEIKKCRFMKENEFKNENKILKNKKIVIVGCGSQGLNQALNMRDSGLNISFALKKNSILRKNSSWLN
ATKNNFEVNDYESLIPNADLVINLTPDKQHENVVKELQKLMKKNSCLGYSHGFNIVECGEIIRKDITVVMVAPKCPGTEV
REEFKRGFGVPTLIAVHTENDPKKIGLEIAKAWAFSTGGHRAGVLESSFIAEVKSDLMGEQTILCGLLQTASLICYEKLI
KDKHNPSYAAKLIQYGWETITESLKHGGITLMMDRLSNPSKIKAFKISKKIKKILSPLFKKHMDDIISGSFSKEMMIDWH
NNDKKLLNWREDTKKTPFEKNILSYSEKISEQEYYDHGTLMVSILKSGIELAFETMINTGIINESAYYESLHELPLIANT
IARKKLYEMNIVISDTAEYGSYLFSEAAYPILKDFIMSLEKNVLGLSLPNTKIDNIELYKINEEIRNHPIEIVGKKLRKH
MKEMKSICVAK
>Mature_491_residues
MNYFNKLCFRKRINEIKKCRFMKENEFKNENKILKNKKIVIVGCGSQGLNQALNMRDSGLNISFALKKNSILRKNSSWLN
ATKNNFEVNDYESLIPNADLVINLTPDKQHENVVKELQKLMKKNSCLGYSHGFNIVECGEIIRKDITVVMVAPKCPGTEV
REEFKRGFGVPTLIAVHTENDPKKIGLEIAKAWAFSTGGHRAGVLESSFIAEVKSDLMGEQTILCGLLQTASLICYEKLI
KDKHNPSYAAKLIQYGWETITESLKHGGITLMMDRLSNPSKIKAFKISKKIKKILSPLFKKHMDDIISGSFSKEMMIDWH
NNDKKLLNWREDTKKTPFEKNILSYSEKISEQEYYDHGTLMVSILKSGIELAFETMINTGIINESAYYESLHELPLIANT
IARKKLYEMNIVISDTAEYGSYLFSEAAYPILKDFIMSLEKNVLGLSLPNTKIDNIELYKINEEIRNHPIEIVGKKLRKH
MKEMKSICVAK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=67.0756646216769, Blast_Score=701, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=290, Percent_Identity=30.3448275862069, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_BUCAP (O51888)

Other databases:

- EMBL:   AF008210
- EMBL:   AE013218
- RefSeq:   NP_660898.1
- ProteinModelPortal:   O51888
- SMR:   O51888
- EnsemblBacteria:   EBBUCT00000000415
- GeneID:   1005622
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg575
- GeneTree:   EBGT00050000007925
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- ProtClustDB:   PRK05225
- BioCyc:   BAPH198804:BUSG575-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 56097; Mature: 56097

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYFNKLCFRKRINEIKKCRFMKENEFKNENKILKNKKIVIVGCGSQGLNQALNMRDSGL
CCHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCCEEEEECCCHHHHHHHCCCCCCC
NISFALKKNSILRKNSSWLNATKNNFEVNDYESLIPNADLVINLTPDKQHENVVKELQKL
CEEEEECCCCHHHCCCCHHCCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
MKKNSCLGYSHGFNIVECGEIIRKDITVVMVAPKCPGTEVREEFKRGFGVPTLIAVHTEN
HHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCC
DPKKIGLEIAKAWAFSTGGHRAGVLESSFIAEVKSDLMGEQTILCGLLQTASLICYEKLI
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KDKHNPSYAAKLIQYGWETITESLKHGGITLMMDRLSNPSKIKAFKISKKIKKILSPLFK
HCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHH
KHMDDIISGSFSKEMMIDWHNNDKKLLNWREDTKKTPFEKNILSYSEKISEQEYYDHGTL
HHHHHHHCCCCCCCEEEEEECCCHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHH
MVSILKSGIELAFETMINTGIINESAYYESLHELPLIANTIARKKLYEMNIVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHEEEEEEECCHHHH
SYLFSEAAYPILKDFIMSLEKNVLGLSLPNTKIDNIELYKINEEIRNHPIEIVGKKLRKH
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHH
MKEMKSICVAK
HHHHHHHHCCC
>Mature Secondary Structure
MNYFNKLCFRKRINEIKKCRFMKENEFKNENKILKNKKIVIVGCGSQGLNQALNMRDSGL
CCHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCCEEEEECCCHHHHHHHCCCCCCC
NISFALKKNSILRKNSSWLNATKNNFEVNDYESLIPNADLVINLTPDKQHENVVKELQKL
CEEEEECCCCHHHCCCCHHCCCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
MKKNSCLGYSHGFNIVECGEIIRKDITVVMVAPKCPGTEVREEFKRGFGVPTLIAVHTEN
HHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCC
DPKKIGLEIAKAWAFSTGGHRAGVLESSFIAEVKSDLMGEQTILCGLLQTASLICYEKLI
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KDKHNPSYAAKLIQYGWETITESLKHGGITLMMDRLSNPSKIKAFKISKKIKKILSPLFK
HCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHH
KHMDDIISGSFSKEMMIDWHNNDKKLLNWREDTKKTPFEKNILSYSEKISEQEYYDHGTL
HHHHHHHCCCCCCCEEEEEECCCHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHH
MVSILKSGIELAFETMINTGIINESAYYESLHELPLIANTIARKKLYEMNIVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHEEEEEEECCHHHH
SYLFSEAAYPILKDFIMSLEKNVLGLSLPNTKIDNIELYKINEEIRNHPIEIVGKKLRKH
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHH
MKEMKSICVAK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9516544; 12089438