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The map label for this gene is gmhA

Identifier: 21672522

GI number: 21672522

Start: 279530

End: 280114

Strand: Direct

Name: gmhA

Synonym: BUsg241

Alternate gene names: 21672522

Gene position: 279530-280114 (Clockwise)

Preceding gene: 21672521

Following gene: 21672523

Centisome position: 43.58

GC content: 27.18

Gene sequence:

>585_bases
ATGTATAAAAAAATTATTTCTTCTGAATTAGATGCTGCATTAAAAATATTAAAAAATTTTTTAAAAAACGAAGAGCAAAT
AGAAAATATTGAAAAGGCAGCTATCTTAATTGCAAAATCCTTTAAAAACAAAAATAAAGTAATTTCATGTGGAAACGGTG
GTTCTCATTGTGATGCAGTTCATTTTTCTGAAGAATTAACTGGTCTTTATCGAGAAAAAAGACCCGGATACGCTGCAATA
CCTATTTCTGATGTTGGTCATATTTCTGCAATAGGAAATGATTTTGGATATGATCAAATATTTTCACGTTATATAGAAAG
TATTGGTTTGCCTAACGACGTACTTCTAGCAATTTCTACTTCCGGAAACTCTATTAATATTATTAATGCAATACAGACTG
CACATAGAAAAAAAATGAAAGTAATTGTTTTAACGGGAAATGATGGAGGTCAAGTTAAACATTTATCTGATGTAGAAATT
TGTATTCCATATCATGGTTATTCAGACCGAATACAAGAAATGCATATTAAGATTATTCATATATTAATATTAATTATTGA
AAAAGAAATGAAAAAAATAAACTAA

Upstream 100 bases:

>100_bases
GTCACGCCGGGGGTCGCGGGTTCGAATCCCGTCCGCACCGAAAAAAATAATTCTCTTTAATAATTTTTTCTATTTTTTTA
AATTTTAAGAACATTCAAAA

Downstream 100 bases:

>100_bases
TTAATCATTGACTTTTATTTTAATAATTATAAATCCTACAATAATTACAAATTATTTCCACTTTTCTAATAAATACTATT
TTATAGTTTTGGATTTTTTT

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MYKKIISSELDAALKILKNFLKNEEQIENIEKAAILIAKSFKNKNKVISCGNGGSHCDAVHFSEELTGLYREKRPGYAAI
PISDVGHISAIGNDFGYDQIFSRYIESIGLPNDVLLAISTSGNSINIINAIQTAHRKKMKVIVLTGNDGGQVKHLSDVEI
CIPYHGYSDRIQEMHIKIIHILILIIEKEMKKIN

Sequences:

>Translated_194_residues
MYKKIISSELDAALKILKNFLKNEEQIENIEKAAILIAKSFKNKNKVISCGNGGSHCDAVHFSEELTGLYREKRPGYAAI
PISDVGHISAIGNDFGYDQIFSRYIESIGLPNDVLLAISTSGNSINIINAIQTAHRKKMKVIVLTGNDGGQVKHLSDVEI
CIPYHGYSDRIQEMHIKIIHILILIIEKEMKKIN
>Mature_194_residues
MYKKIISSELDAALKILKNFLKNEEQIENIEKAAILIAKSFKNKNKVISCGNGGSHCDAVHFSEELTGLYREKRPGYAAI
PISDVGHISAIGNDFGYDQIFSRYIESIGLPNDVLLAISTSGNSINIINAIQTAHRKKMKVIVLTGNDGGQVKHLSDVEI
CIPYHGYSDRIQEMHIKIIHILILIIEKEMKKIN

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=192, Percent_Identity=62.5, Blast_Score=257, Evalue=4e-70,
Organism=Escherichia coli, GI1789539, Length=167, Percent_Identity=38.3233532934132, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_BUCAP (Q8K9R9)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660589.1
- ProteinModelPortal:   Q8K9R9
- SMR:   Q8K9R9
- EnsemblBacteria:   EBBUCT00000000228
- GeneID:   1005442
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg241
- GeneTree:   EBGT00050000008131
- HOGENOM:   HBG671955
- OMA:   ANDLGYD
- ProtClustDB:   PRK00414
- BioCyc:   BAPH198804:BUSG241-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 21631; Mature: 21631

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS51464 SIS

Important sites: BINDING 65-65 BINDING 124-124 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKKIISSELDAALKILKNFLKNEEQIENIEKAAILIAKSFKNKNKVISCGNGGSHCDAV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHH
HFSEELTGLYREKRPGYAAIPISDVGHISAIGNDFGYDQIFSRYIESIGLPNDVLLAIST
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGNSINIINAIQTAHRKKMKVIVLTGNDGGQVKHLSDVEICIPYHGYSDRIQEMHIKIIH
CCCEEEHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHH
ILILIIEKEMKKIN
HHHHHHHHHHHHCC
>Mature Secondary Structure
MYKKIISSELDAALKILKNFLKNEEQIENIEKAAILIAKSFKNKNKVISCGNGGSHCDAV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHH
HFSEELTGLYREKRPGYAAIPISDVGHISAIGNDFGYDQIFSRYIESIGLPNDVLLAIST
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGNSINIINAIQTAHRKKMKVIVLTGNDGGQVKHLSDVEICIPYHGYSDRIQEMHIKIIH
CCCEEEHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHH
ILILIIEKEMKKIN
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438