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The map label for this gene is hpt

Identifier: 21672476

GI number: 21672476

Start: 213256

End: 213789

Strand: Direct

Name: hpt

Synonym: BUsg189

Alternate gene names: 21672476

Gene position: 213256-213789 (Clockwise)

Preceding gene: 21672472

Following gene: 21672480

Centisome position: 33.25

GC content: 25.47

Gene sequence:

>534_bases
ATGAAACATACTATCAAAGTGATTATTTCTGAAAAAGAACTAGATATTCGCGTTCGTGAATTGGGTGAAGAAATTACTAA
AAAATATAAAAATAGTAAAAATAAAATAATATTAATTGCTTTATTACGTGGTTCATTTGTATTTATAGCAGATTTATGTC
GTAGAATTAAAATTGAACATGAAATTGATTTTATGACCACTTCTAGTTATGGACGTGGCATGATATCTACTGGAGATGTA
AAAATTATAAAAGATTTAGACGAGGATATCTATAACAAAAATGTTTTAATTGTTGAAGATATTATTGATTCTGGAAAAAC
GTTAAGTAAAGTACTAGGTATTTTAAAATTAAGAAATCCGAAATCATTATCAATTTGCACTCTTTTAGATAAGCCAGAAT
GTCGTGAAGTTAATATTAATATTGATTTTGTAGGTTTCTCTATACCTGATGAATTTATGGTTGGATATGGAATAGATTAT
GCTCAATCTTATCGATATTTACCATATATAGGAAAAGTGATTTTTAAAAAATAA

Upstream 100 bases:

>100_bases
CAATTTTTGTTGTTGAATATACTCGCTATTTTGAATAAATATCAATAAATGATTTTTAGTATAATAATTTAAAATATACA
TTAAAAACTTATTTCATATT

Downstream 100 bases:

>100_bases
AAATTTTTTTAATCTCTTAGTATTATTTTTTTATTGTCAATTAATCGAATTTTTCCTAACCAAACTGATGCTATTATAAT
AATATTTTTGCTGTCTTTAG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MKHTIKVIISEKELDIRVRELGEEITKKYKNSKNKIILIALLRGSFVFIADLCRRIKIEHEIDFMTTSSYGRGMISTGDV
KIIKDLDEDIYNKNVLIVEDIIDSGKTLSKVLGILKLRNPKSLSICTLLDKPECREVNINIDFVGFSIPDEFMVGYGIDY
AQSYRYLPYIGKVIFKK

Sequences:

>Translated_177_residues
MKHTIKVIISEKELDIRVRELGEEITKKYKNSKNKIILIALLRGSFVFIADLCRRIKIEHEIDFMTTSSYGRGMISTGDV
KIIKDLDEDIYNKNVLIVEDIIDSGKTLSKVLGILKLRNPKSLSICTLLDKPECREVNINIDFVGFSIPDEFMVGYGIDY
AQSYRYLPYIGKVIFKK
>Mature_177_residues
MKHTIKVIISEKELDIRVRELGEEITKKYKNSKNKIILIALLRGSFVFIADLCRRIKIEHEIDFMTTSSYGRGMISTGDV
KIIKDLDEDIYNKNVLIVEDIIDSGKTLSKVLGILKLRNPKSLSICTLLDKPECREVNINIDFVGFSIPDEFMVGYGIDY
AQSYRYLPYIGKVIFKK

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4504483, Length=175, Percent_Identity=37.1428571428571, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI9910262, Length=164, Percent_Identity=32.3170731707317, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI87081689, Length=175, Percent_Identity=68, Blast_Score=256, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17510817, Length=173, Percent_Identity=36.9942196531792, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_BUCAP (Q8K9U8)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660543.1
- ProteinModelPortal:   Q8K9U8
- SMR:   Q8K9U8
- EnsemblBacteria:   EBBUCT00000000419
- GeneID:   1005386
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg189
- GeneTree:   EBGT00050000007946
- HOGENOM:   HBG536385
- OMA:   INAHYAD
- ProtClustDB:   CLSK315778
- BioCyc:   BAPH198804:BUSG189-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20342; Mature: 20342

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTIKVIISEKELDIRVRELGEEITKKYKNSKNKIILIALLRGSFVFIADLCRRIKIEH
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
EIDFMTTSSYGRGMISTGDVKIIKDLDEDIYNKNVLIVEDIIDSGKTLSKVLGILKLRNP
EEEEEEECCCCCCCEECCCEEEEHHHHHHHHCCCEEEEEHHHCCCHHHHHHHHHHHCCCC
KSLSICTLLDKPECREVNINIDFVGFSIPDEFMVGYGIDYAQSYRYLPYIGKVIFKK
CCEEEEEECCCCCCEEEEEEEEEEEECCCHHHHEECCCCHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure
MKHTIKVIISEKELDIRVRELGEEITKKYKNSKNKIILIALLRGSFVFIADLCRRIKIEH
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
EIDFMTTSSYGRGMISTGDVKIIKDLDEDIYNKNVLIVEDIIDSGKTLSKVLGILKLRNP
EEEEEEECCCCCCCEECCCEEEEHHHHHHHHCCCEEEEEHHHCCCHHHHHHHHHHHCCCC
KSLSICTLLDKPECREVNINIDFVGFSIPDEFMVGYGIDYAQSYRYLPYIGKVIFKK
CCEEEEEECCCCCCEEEEEEEEEEEECCCHHHHEECCCCHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438