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The map label for this gene is apaH

Identifier: 21672425

GI number: 21672425

Start: 149082

End: 149903

Strand: Direct

Name: apaH

Synonym: BUsg135

Alternate gene names: 21672425

Gene position: 149082-149903 (Clockwise)

Preceding gene: 21672424

Following gene: 21672434

Centisome position: 23.24

GC content: 25.18

Gene sequence:

>822_bases
ATGAGCATTTATTTTATCAGTGATATTCATGGTTGTTATAAAGAATTCAAGTTACTTTTAAAAAAATCTTTTTTTAATGA
TAAAAAAGATTTTTTATGGATTGCAGGTGATCTAGTATCTAGAGGACCAGATTCTCTTAAAGTAATAAGATATCTTTATT
CTTTAAGAAAACGAATAAAAATCATACTTGGAAATCATGATTTAAACTTAATTGCAGTGTATTCTGGTGTTAAAGAAAAT
AAAAAAGAAAATTATTTTGATGAATTTTTATCTGCAAAAGATAATTTACAATTGATTAATTGGTTGCGATGTCAATCTAT
TTTAAAAATTGATGAAGAAAGAAAAATTATTATGTCACATGCTGGTATTAGTCCTAAATGGGATATCGATACAGCAAAAA
AATATGCGTTAGAAATTGAAAAATGTTTATCAGGTAAAAATTATTCTTCATTTTTAAGATCTGTTTTTAACAATAAAATT
AATTATTGGAACTTAAATTTAAATAAATTAGACCGATTACGATATAGTATTAACGTTTTTACGCGTATGCGATATTGTTA
TCCTGATAGTAGATTAAACCTTATTTGTAAAAAATCTCCTAATTTAGTTAAATATCCTCTGATACCATGGTTTAAAATAC
CAAATAAGATTCCAAAAGAATATTCAGTTTTTTTTGGACACTGGTCTTCTTTAATAGGAACAAAGGTACCTCAACCATTT
TTTCCATTAGATAGTGGTTGTTGTTGGGGAGGAAAATTAACCATGTTTCGATGGGAAGATAAAAAATACTTTTTTCAATC
TTTTCAAAAAAACAATAGTTAA

Upstream 100 bases:

>100_bases
TACTGCAGTATTGCCAACTATCTAATTATATAATTGAAAATGATATTTTAAAAAATAAAAATTTTAATTAATTATTTTCT
TTTAAAAAAGTGAAAAATAT

Downstream 100 bases:

>100_bases
AATTAAATTAAAAATATTTAATTAATATATTTTTTTATCTTGATAAAATTTCAAAACAAAAATTATAAGGATTATTTTTA
TCTTTAAAATGTTGTTTTCT

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSIYFISDIHGCYKEFKLLLKKSFFNDKKDFLWIAGDLVSRGPDSLKVIRYLYSLRKRIKIILGNHDLNLIAVYSGVKEN
KKENYFDEFLSAKDNLQLINWLRCQSILKIDEERKIIMSHAGISPKWDIDTAKKYALEIEKCLSGKNYSSFLRSVFNNKI
NYWNLNLNKLDRLRYSINVFTRMRYCYPDSRLNLICKKSPNLVKYPLIPWFKIPNKIPKEYSVFFGHWSSLIGTKVPQPF
FPLDSGCCWGGKLTMFRWEDKKYFFQSFQKNNS

Sequences:

>Translated_273_residues
MSIYFISDIHGCYKEFKLLLKKSFFNDKKDFLWIAGDLVSRGPDSLKVIRYLYSLRKRIKIILGNHDLNLIAVYSGVKEN
KKENYFDEFLSAKDNLQLINWLRCQSILKIDEERKIIMSHAGISPKWDIDTAKKYALEIEKCLSGKNYSSFLRSVFNNKI
NYWNLNLNKLDRLRYSINVFTRMRYCYPDSRLNLICKKSPNLVKYPLIPWFKIPNKIPKEYSVFFGHWSSLIGTKVPQPF
FPLDSGCCWGGKLTMFRWEDKKYFFQSFQKNNS
>Mature_272_residues
SIYFISDIHGCYKEFKLLLKKSFFNDKKDFLWIAGDLVSRGPDSLKVIRYLYSLRKRIKIILGNHDLNLIAVYSGVKENK
KENYFDEFLSAKDNLQLINWLRCQSILKIDEERKIIMSHAGISPKWDIDTAKKYALEIEKCLSGKNYSSFLRSVFNNKIN
YWNLNLNKLDRLRYSINVFTRMRYCYPDSRLNLICKKSPNLVKYPLIPWFKIPNKIPKEYSVFFGHWSSLIGTKVPQPFF
PLDSGCCWGGKLTMFRWEDKKYFFQSFQKNNS

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=271, Percent_Identity=48.3394833948339, Blast_Score=305, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_BUCAP (Q8K9Z9)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660492.1
- ProteinModelPortal:   Q8K9Z9
- SMR:   Q8K9Z9
- EnsemblBacteria:   EBBUCT00000000093
- GeneID:   1005952
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg135
- GeneTree:   EBGT00050000008157
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- ProtClustDB:   PRK00166
- BioCyc:   BAPH198804:BUSG135-MONOMER
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 32424; Mature: 32293

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYFISDIHGCYKEFKLLLKKSFFNDKKDFLWIAGDLVSRGPDSLKVIRYLYSLRKRIK
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHEE
IILGNHDLNLIAVYSGVKENKKENYFDEFLSAKDNLQLINWLRCQSILKIDEERKIIMSH
EEECCCCCEEEEEECCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHEEEHH
AGISPKWDIDTAKKYALEIEKCLSGKNYSSFLRSVFNNKINYWNLNLNKLDRLRYSINVF
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
TRMRYCYPDSRLNLICKKSPNLVKYPLIPWFKIPNKIPKEYSVFFGHWSSLIGTKVPQPF
HHHHEECCCCCEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
FPLDSGCCWGGKLTMFRWEDKKYFFQSFQKNNS
CCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCC
>Mature Secondary Structure 
SIYFISDIHGCYKEFKLLLKKSFFNDKKDFLWIAGDLVSRGPDSLKVIRYLYSLRKRIK
EEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHEE
IILGNHDLNLIAVYSGVKENKKENYFDEFLSAKDNLQLINWLRCQSILKIDEERKIIMSH
EEECCCCCEEEEEECCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHEEEHH
AGISPKWDIDTAKKYALEIEKCLSGKNYSSFLRSVFNNKINYWNLNLNKLDRLRYSINVF
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
TRMRYCYPDSRLNLICKKSPNLVKYPLIPWFKIPNKIPKEYSVFFGHWSSLIGTKVPQPF
HHHHEECCCCCEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
FPLDSGCCWGGKLTMFRWEDKKYFFQSFQKNNS
CCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438