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The map label for this gene is fabB

Identifier: 21672376

GI number: 21672376

Start: 94715

End: 95938

Strand: Direct

Name: fabB

Synonym: BUsg084

Alternate gene names: 21672376

Gene position: 94715-95938 (Clockwise)

Preceding gene: 21672374

Following gene: 21672377

Centisome position: 14.77

GC content: 29.25

Gene sequence:

>1224_bases
GTGAAACGAGTCGTAATTACTGGATTTGGTATTATTTCAAGTATTGGAAATAATAAAAAAGAAGTTTTAAATTCTTTATA
TAATGGTATTTCTGGAATTACATTTTCAGAAGAAATGAAAGAATCAGGTATGCGTAGTCAAGTTTGGGGAAATATAAAAT
TAGAAAATAAAAAATTTTTTAAAAAAAATAAAATCTCTCGTTTTATGAACAATGGATCTATTTATGCTTTTTTGTCAATG
GAGCAAGCAATAAAAGATGCTAACTTACAAACTAAACAATATCAAAAAAATCCACGTATTGGAATTATTGCTGGTTCTGG
AGGTGGTTTTCCAAAATATCATATACAGGGCATAGATGCTATCAGAAGCAATCGAGGTCTAAATTCTGTTAGTCCTTATA
TTGCAATTAAAGCTATGAATTCTGGAATATCCGCTTGTTTGTCAACTTTATTTAAAATATATGGAGTAAATTATTCTATA
AGTTCAGCTTGTGCGACTTCTGGACATTGTATTGGTAATGCATTTGAGTTAATTAAATTTGGTAAGCAAGATCTTATTTT
TGCAGGAGGAGGTGAAGAGGTAAGTTGGGAATTAGCATATGAATTTGATGCAATGAAAGCTCTTTCTAGTAATTTTAACA
AAAATCCTACTAAATCATCGCGTGTTTATGATGTAAACCGTGATGGTTTTGTCATATCTGGTGGTGGAGGTATAATAGTT
ATTGAAGAGTTAAATTGTGCTTTATCTAGATCTGCTCACATTTATGCTGAAATTATTGGCTATGCTGCAACATCTGACGG
TAAAGATATGGTTGTACCATCAGGAGATGGAGCGGTACGCTGTATGAATTTAGCAAAAAAACAAAACAAAATGTTATTTA
TTGATTATTTAAATGTTCATGGGACTTCTACTAAAATTGGTGATCTTATTGAATTAGAAGCAATTAAAAAATCTTTTTTT
CATGAAAAAAAACCTATGATTTCAGCAACAAAATCGATGACTGGTCATGCTTTAGGAGTATCTGGAGTACATGAAATTAT
TTATACATTATTAATGATGAAGTATAATTTTATAGCTCCTTCAATTAATATTGAAACAATAGAACCTTCTGCTGACAATA
TGAATATTGTACAAAAAACTTTTCATAAAAAAATTAAAACAGCACTATCTAATAGTTTTGGTTTTGGTGGAACTAATGTT
TCTTTGATATTAAAAAAGTATTAA

Upstream 100 bases:

>100_bases
GTAATAAAAAAAAATAATAATTTATTATATAAGTAATATTAAATTTAAGTTGTTTTTATATGTAAATTTGATGTTAAAGA
ATAATTATAAGGTATTTTAA

Downstream 100 bases:

>100_bases
TTTTTTATAAAAAAATACTTTTTAATATTTTTCATGCACAATGTATTTAATATTGTTAAGTAAAATACGTTTTTTTTACA
TATAATTTTAATCTTTGATT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKRVVITGFGIISSIGNNKKEVLNSLYNGISGITFSEEMKESGMRSQVWGNIKLENKKFFKKNKISRFMNNGSIYAFLSM
EQAIKDANLQTKQYQKNPRIGIIAGSGGGFPKYHIQGIDAIRSNRGLNSVSPYIAIKAMNSGISACLSTLFKIYGVNYSI
SSACATSGHCIGNAFELIKFGKQDLIFAGGGEEVSWELAYEFDAMKALSSNFNKNPTKSSRVYDVNRDGFVISGGGGIIV
IEELNCALSRSAHIYAEIIGYAATSDGKDMVVPSGDGAVRCMNLAKKQNKMLFIDYLNVHGTSTKIGDLIELEAIKKSFF
HEKKPMISATKSMTGHALGVSGVHEIIYTLLMMKYNFIAPSINIETIEPSADNMNIVQKTFHKKIKTALSNSFGFGGTNV
SLILKKY

Sequences:

>Translated_407_residues
MKRVVITGFGIISSIGNNKKEVLNSLYNGISGITFSEEMKESGMRSQVWGNIKLENKKFFKKNKISRFMNNGSIYAFLSM
EQAIKDANLQTKQYQKNPRIGIIAGSGGGFPKYHIQGIDAIRSNRGLNSVSPYIAIKAMNSGISACLSTLFKIYGVNYSI
SSACATSGHCIGNAFELIKFGKQDLIFAGGGEEVSWELAYEFDAMKALSSNFNKNPTKSSRVYDVNRDGFVISGGGGIIV
IEELNCALSRSAHIYAEIIGYAATSDGKDMVVPSGDGAVRCMNLAKKQNKMLFIDYLNVHGTSTKIGDLIELEAIKKSFF
HEKKPMISATKSMTGHALGVSGVHEIIYTLLMMKYNFIAPSINIETIEPSADNMNIVQKTFHKKIKTALSNSFGFGGTNV
SLILKKY
>Mature_407_residues
MKRVVITGFGIISSIGNNKKEVLNSLYNGISGITFSEEMKESGMRSQVWGNIKLENKKFFKKNKISRFMNNGSIYAFLSM
EQAIKDANLQTKQYQKNPRIGIIAGSGGGFPKYHIQGIDAIRSNRGLNSVSPYIAIKAMNSGISACLSTLFKIYGVNYSI
SSACATSGHCIGNAFELIKFGKQDLIFAGGGEEVSWELAYEFDAMKALSSNFNKNPTKSSRVYDVNRDGFVISGGGGIIV
IEELNCALSRSAHIYAEIIGYAATSDGKDMVVPSGDGAVRCMNLAKKQNKMLFIDYLNVHGTSTKIGDLIELEAIKKSFF
HEKKPMISATKSMTGHALGVSGVHEIIYTLLMMKYNFIAPSINIETIEPSADNMNIVQKTFHKKIKTALSNSFGFGGTNV
SLILKKY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=32.9355608591885, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=36.4705882352941, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=22.5882352941176, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=62.807881773399, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=33.0143540669856, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=32.2195704057279, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=36.9230769230769, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17550940, Length=277, Percent_Identity=27.4368231046931, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI212642053, Length=294, Percent_Identity=27.2108843537415, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=29.6875, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=35.781990521327, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI221330659, Length=426, Percent_Identity=25.1173708920188, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19920632, Length=274, Percent_Identity=27.007299270073, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=21.1267605633803, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FABB_BUCAP (Q8KA28)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660443.1
- ProteinModelPortal:   Q8KA28
- SMR:   Q8KA28
- EnsemblBacteria:   EBBUCT00000000508
- GeneID:   1005901
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg084
- GeneTree:   EBGT00050000007996
- HOGENOM:   HBG757733
- OMA:   RSAHIYA
- ProtClustDB:   CLSK315248
- BioCyc:   BAPH198804:BUSG084-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR11712

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 44524; Mature: 44524

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: ACT_SITE 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGFGIISSIGNNKKEVLNSLYNGISGITFSEEMKESGMRSQVWGNIKLENKKFF
CCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHCCCCHHHCCCEEECCCHHH
KKNKISRFMNNGSIYAFLSMEQAIKDANLQTKQYQKNPRIGIIAGSGGGFPKYHIQGIDA
HHHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCCEEECCHHH
IRSNRGLNSVSPYIAIKAMNSGISACLSTLFKIYGVNYSISSACATSGHCIGNAFELIKF
HHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHC
GKQDLIFAGGGEEVSWELAYEFDAMKALSSNFNKNPTKSSRVYDVNRDGFVISGGGGIIV
CCCCEEEECCCCCEEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCEEE
IEELNCALSRSAHIYAEIIGYAATSDGKDMVVPSGDGAVRCMNLAKKQNKMLFIDYLNVH
EEECCHHHCCCCEEEEHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEEECC
GTSTKIGDLIELEAIKKSFFHEKKPMISATKSMTGHALGVSGVHEIIYTLLMMKYNFIAP
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SINIETIEPSADNMNIVQKTFHKKIKTALSNSFGFGGTNVSLILKKY
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKRVVITGFGIISSIGNNKKEVLNSLYNGISGITFSEEMKESGMRSQVWGNIKLENKKFF
CCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHCCCCHHHCCCEEECCCHHH
KKNKISRFMNNGSIYAFLSMEQAIKDANLQTKQYQKNPRIGIIAGSGGGFPKYHIQGIDA
HHHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCCEEECCHHH
IRSNRGLNSVSPYIAIKAMNSGISACLSTLFKIYGVNYSISSACATSGHCIGNAFELIKF
HHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHC
GKQDLIFAGGGEEVSWELAYEFDAMKALSSNFNKNPTKSSRVYDVNRDGFVISGGGGIIV
CCCCEEEECCCCCEEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCEEE
IEELNCALSRSAHIYAEIIGYAATSDGKDMVVPSGDGAVRCMNLAKKQNKMLFIDYLNVH
EEECCHHHCCCCEEEEHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEEECC
GTSTKIGDLIELEAIKKSFFHEKKPMISATKSMTGHALGVSGVHEIIYTLLMMKYNFIAP
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SINIETIEPSADNMNIVQKTFHKKIKTALSNSFGFGGTNVSLILKKY
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438