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The map label for this gene is yhdG [H]

Identifier: 21245066

GI number: 21245066

Start: 5146339

End: 5147754

Strand: Direct

Name: yhdG [H]

Synonym: XAC4354

Alternate gene names: 21245066

Gene position: 5146339-5147754 (Clockwise)

Preceding gene: 21245065

Following gene: 21245077

Centisome position: 99.44

GC content: 66.6

Gene sequence:

>1416_bases
ATGTCGTCTTGGCTCAGGCGCAAATCCATCGATCAGGTCACCGTGCACGAGGCCGGCCGGCAACTGGTCCGCAGCCTGAG
TTGGCCGCATCTGATCGCGCTGGGCATCGGCGCCATCGTCGGTACCGGGATCTACACGTTGATCGGCGTGGGCGCCGACA
AGGCCGGACCGGCAGTGTTGCTGTCGTTCGTGGCGGCCGGCATCGTGTGCGCCTGCGCGGCGCTGGCCTATGCCGAGATG
GCCACGATGATGCCGGCTGCCGGCAGTGCGTATACCTACAGCTACACCGCGCTGGGCGAGAGCATTGCCTGGGTGGTGGG
CTGGAGCCTGGTGCTGGAATACTCGCTGGTGGTCAGCACGGTGGCGGTCGGCTGGTCGGGCTATTTCGTCGGTTTCCTGC
AATGGTTGGGCGTGGGGTTGCCGCAGGCACTCATTGCCGGGCCGCACGCCGGCGGCATCGTCAACCTGCCGGCGGTGGCG
ATCACTTTCCTGGTGGCTGGCCTGTTGATGGCCGGCACCAAGGAAAGCGCCACGCTCAACGCGGTACTGGTCGTGCTGAA
GATCATCGCGCTGGGCGTGTTCGTGGCCATTGCGCTGCCGGCCTTCAACAGCGCCAACCTGCAGCCGTTCATGCCGTATG
GCTTCTCCAAGGCGATGGGCCCCGATGGCATCGAGCGCGGGGTGATGGCAGCGGCGGCGATCATCTTCTTTGCGTTCTAC
GGCTTCGATGCGATTTCCACCGCGGCCGAGGAAACCAAGAACCCCGGGCGCGATCTGTCGATCGGCATCGTCGGTTCGAT
GATCGGCTGCACGCTGATCTATGTGCTGGTGGCGCTGGCCGCGGTGGGTGCGATGAGCTTTACCGTGTTCGGCAAGAGCC
CCGAGCCGTTGGCGCTGATCCTGCGCGAACTCGGCCACGGCAAGGCGGCCTTGGTGATCGGTGCGGTGGCGATCATTGCG
TTACCCACGGTGTTGCTGGCGTTTTTGTACGGGCAGAGCCGCATCTTCTTCGTGATGTCGCGCGATGGCTTGTTGCCGCG
CGGCTTGTCCAAGGTCAATGCACGCACCGGCACGCCGGTGGCGATCACGCTGTTCACCGCGGTGCTGGTGGCGGCACTGG
CCGGCGTGGCCCGGCTGGACGAAATCGCCGCCTTGGCCAACGCCGGCACGCTGGCGGCGTTCACGGCGGTGGCGGCCTGC
CTGTTGGTGTTGCGCGTGCGCGAGCCCGGCCGCGCGCGCGCCTTCCGCACGCCGCTGGCGTGGGTGGTGGGACCGGTGGC
GATCGGCGGCTGCCTGTATCTGTTCTGGAGCCTGCCGAGCAAGACGCAGGGCTGGTTCCTGCTGTGGAATGCGCTGGGCG
TGGTGGTGTACCTGGCGTATGGGCGGCGGAATAGCCGGTTGAATCAGGCGGGCTGA

Upstream 100 bases:

>100_bases
CACCTTGCCCAGGCACGGCTGCTGCATGACCTTGGACCGATAGCTTTGCTGCGCTGCGTTGGGCGACACTCGCGCATTCT
TTGATTCCCGCGAGGTCCGC

Downstream 100 bases:

>100_bases
GCGTCCTTCTCCCTGCGGGAGAAGGTGCCCCGCAGGGGCGGATGAGGGTGCGGGCGTAGCCTCTTGCAGGGGGTAACACG
AGGGCTTTGCCTCGTCCCCT

Product: amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSSWLRRKSIDQVTVHEAGRQLVRSLSWPHLIALGIGAIVGTGIYTLIGVGADKAGPAVLLSFVAAGIVCACAALAYAEM
ATMMPAAGSAYTYSYTALGESIAWVVGWSLVLEYSLVVSTVAVGWSGYFVGFLQWLGVGLPQALIAGPHAGGIVNLPAVA
ITFLVAGLLMAGTKESATLNAVLVVLKIIALGVFVAIALPAFNSANLQPFMPYGFSKAMGPDGIERGVMAAAAIIFFAFY
GFDAISTAAEETKNPGRDLSIGIVGSMIGCTLIYVLVALAAVGAMSFTVFGKSPEPLALILRELGHGKAALVIGAVAIIA
LPTVLLAFLYGQSRIFFVMSRDGLLPRGLSKVNARTGTPVAITLFTAVLVAALAGVARLDEIAALANAGTLAAFTAVAAC
LLVLRVREPGRARAFRTPLAWVVGPVAIGGCLYLFWSLPSKTQGWFLLWNALGVVVYLAYGRRNSRLNQAG

Sequences:

>Translated_471_residues
MSSWLRRKSIDQVTVHEAGRQLVRSLSWPHLIALGIGAIVGTGIYTLIGVGADKAGPAVLLSFVAAGIVCACAALAYAEM
ATMMPAAGSAYTYSYTALGESIAWVVGWSLVLEYSLVVSTVAVGWSGYFVGFLQWLGVGLPQALIAGPHAGGIVNLPAVA
ITFLVAGLLMAGTKESATLNAVLVVLKIIALGVFVAIALPAFNSANLQPFMPYGFSKAMGPDGIERGVMAAAAIIFFAFY
GFDAISTAAEETKNPGRDLSIGIVGSMIGCTLIYVLVALAAVGAMSFTVFGKSPEPLALILRELGHGKAALVIGAVAIIA
LPTVLLAFLYGQSRIFFVMSRDGLLPRGLSKVNARTGTPVAITLFTAVLVAALAGVARLDEIAALANAGTLAAFTAVAAC
LLVLRVREPGRARAFRTPLAWVVGPVAIGGCLYLFWSLPSKTQGWFLLWNALGVVVYLAYGRRNSRLNQAG
>Mature_470_residues
SSWLRRKSIDQVTVHEAGRQLVRSLSWPHLIALGIGAIVGTGIYTLIGVGADKAGPAVLLSFVAAGIVCACAALAYAEMA
TMMPAAGSAYTYSYTALGESIAWVVGWSLVLEYSLVVSTVAVGWSGYFVGFLQWLGVGLPQALIAGPHAGGIVNLPAVAI
TFLVAGLLMAGTKESATLNAVLVVLKIIALGVFVAIALPAFNSANLQPFMPYGFSKAMGPDGIERGVMAAAAIIFFAFYG
FDAISTAAEETKNPGRDLSIGIVGSMIGCTLIYVLVALAAVGAMSFTVFGKSPEPLALILRELGHGKAALVIGAVAIIAL
PTVLLAFLYGQSRIFFVMSRDGLLPRGLSKVNARTGTPVAITLFTAVLVAALAGVARLDEIAALANAGTLAAFTAVAACL
LVLRVREPGRARAFRTPLAWVVGPVAIGGCLYLFWSLPSKTQGWFLLWNALGVVVYLAYGRRNSRLNQAG

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=440, Percent_Identity=34.5454545454545, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI258614003, Length=441, Percent_Identity=34.6938775510204, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI258645169, Length=441, Percent_Identity=36.0544217687075, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4507047, Length=440, Percent_Identity=33.4090909090909, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI114326544, Length=443, Percent_Identity=32.5056433408578, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI114326550, Length=443, Percent_Identity=32.5056433408578, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI110347453, Length=416, Percent_Identity=34.6153846153846, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI181337167, Length=408, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI115648063, Length=407, Percent_Identity=25.7985257985258, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI115648022, Length=407, Percent_Identity=25.7985257985258, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI186910308, Length=404, Percent_Identity=25.2475247524752, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI186910306, Length=404, Percent_Identity=25.2475247524752, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI186910304, Length=404, Percent_Identity=25.2475247524752, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI71979932, Length=210, Percent_Identity=30.4761904761905, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1786302, Length=366, Percent_Identity=26.775956284153, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789017, Length=356, Percent_Identity=25.8426966292135, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081869, Length=472, Percent_Identity=24.1525423728814, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786789, Length=424, Percent_Identity=23.8207547169811, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081915, Length=439, Percent_Identity=24.373576309795, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=22.8637413394919, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082023, Length=484, Percent_Identity=25.4132231404959, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788480, Length=354, Percent_Identity=25.4237288135593, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082250, Length=348, Percent_Identity=24.4252873563218, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081708, Length=425, Percent_Identity=23.0588235294118, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=406, Percent_Identity=33.4975369458128, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17533459, Length=408, Percent_Identity=30.8823529411765, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17531343, Length=418, Percent_Identity=29.1866028708134, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17540018, Length=440, Percent_Identity=24.3181818181818, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32566699, Length=383, Percent_Identity=23.7597911227154, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71990446, Length=423, Percent_Identity=22.9314420803783, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321053, Length=383, Percent_Identity=24.2819843342037, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668806, Length=420, Percent_Identity=37.1428571428571, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI21356285, Length=420, Percent_Identity=37.1428571428571, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24668802, Length=420, Percent_Identity=37.1428571428571, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24667468, Length=425, Percent_Identity=34.3529411764706, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI221512776, Length=432, Percent_Identity=33.5648148148148, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24666159, Length=434, Percent_Identity=34.331797235023, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI161077963, Length=435, Percent_Identity=31.264367816092, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI281366235, Length=411, Percent_Identity=30.9002433090024, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI116007820, Length=411, Percent_Identity=30.9002433090024, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI116007818, Length=408, Percent_Identity=31.1274509803922, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI85725152, Length=408, Percent_Identity=31.1274509803922, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45550968, Length=418, Percent_Identity=24.4019138755981, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921172, Length=418, Percent_Identity=24.4019138755981, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331183, Length=412, Percent_Identity=24.7572815533981, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647653, Length=412, Percent_Identity=24.7572815533981, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664379, Length=412, Percent_Identity=24.7572815533981, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357367, Length=403, Percent_Identity=23.8213399503722, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48994; Mature: 48862

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSWLRRKSIDQVTVHEAGRQLVRSLSWPHLIALGIGAIVGTGIYTLIGVGADKAGPAVL
CCCHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LSFVAAGIVCACAALAYAEMATMMPAAGSAYTYSYTALGESIAWVVGWSLVLEYSLVVST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVGWSGYFVGFLQWLGVGLPQALIAGPHAGGIVNLPAVAITFLVAGLLMAGTKESATLN
HHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHH
AVLVVLKIIALGVFVAIALPAFNSANLQPFMPYGFSKAMGPDGIERGVMAAAAIIFFAFY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GFDAISTAAEETKNPGRDLSIGIVGSMIGCTLIYVLVALAAVGAMSFTVFGKSPEPLALI
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHH
LRELGHGKAALVIGAVAIIALPTVLLAFLYGQSRIFFVMSRDGLLPRGLSKVNARTGTPV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCH
AITLFTAVLVAALAGVARLDEIAALANAGTLAAFTAVAACLLVLRVREPGRARAFRTPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHH
WVVGPVAIGGCLYLFWSLPSKTQGWFLLWNALGVVVYLAYGRRNSRLNQAG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SSWLRRKSIDQVTVHEAGRQLVRSLSWPHLIALGIGAIVGTGIYTLIGVGADKAGPAVL
CCHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH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HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]