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The map label for this gene is tdk

Identifier: 21244999

GI number: 21244999

Start: 5058832

End: 5059461

Strand: Direct

Name: tdk

Synonym: XAC4282

Alternate gene names: 21244999

Gene position: 5058832-5059461 (Clockwise)

Preceding gene: 21244995

Following gene: 21245000

Centisome position: 97.74

GC content: 65.56

Gene sequence:

>630_bases
ATGGCCAAGCTCTATTTCTACTATTCGGCAATGAATGCCGGCAAGACCACCACCTTGCTGCAATCGGCGCACAACTACCG
CGAGCGCGGCATGCGCACGCTGATCCTTACGCCCAAGCTCGACCACCGCGCCGGCAGCGGCGTGGTCGCCTCGCGAATCG
GCCTGCGCGCGGACGGGCGTATCTTCGAGCGCGACACCGAGCTGCAACAGCTGGTCGAACGCGACATCCACAACGACGGC
GCGTTGCACTGCGTGCTGGTGGACGAAGCGCAATTCCTCAGCCGCGCCCAGGTCTGGCAGTTGAGCGAGGTGGTCGACCG
CCTGCGCATTCCGGTGCTGTGCTACGGCCTGCGCACCGATTTTCGCGGCGAGCTGTTCGAGGGCAGCCAGTTCCTGCTGG
CCTGGGCCGACGAGCTGGAAGAGATCAAGACCATCTGCCACAGCGGCAGCAAGGCGACCATGACCGTGCGCGTGGATGCG
CACGGGCACGCGGTGCAGGACGGCCCGCAGGTGGAGATCGGCGGCAACGAGCGCTATGTGTCGGTCAGCCGGGCCGAGTT
CAAGAAGATCATGCGCGGCGAAGGCCGCATCGATCCGCTACAGATCGCCTTGCCGCTGCCGGTTGCCTAG

Upstream 100 bases:

>100_bases
TGCGCTTCCCCCCACTCGACGGCGGACATTGGCGCCGCCTGGCCGCGCCAACGCAGCGCACAGGCGCCGCATCCTGCCGC
CCGGCCGGTAAAATCGCCCG

Downstream 100 bases:

>100_bases
CGCCGGGGCCGGGTCACGCACCCGCAGCCATCCGCGCCCCGTGGTGCATTCAGGACGGCAGTACCCCATGAGCAGCAGCA
TTCGGGCGCATCCTCGTTTG

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MAKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTLILTPKLDHRAGSGVVASRIGLRADGRIFERDTELQQLVERDIHNDG
ALHCVLVDEAQFLSRAQVWQLSEVVDRLRIPVLCYGLRTDFRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDA
HGHAVQDGPQVEIGGNERYVSVSRAEFKKIMRGEGRIDPLQIALPLPVA

Sequences:

>Translated_209_residues
MAKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTLILTPKLDHRAGSGVVASRIGLRADGRIFERDTELQQLVERDIHNDG
ALHCVLVDEAQFLSRAQVWQLSEVVDRLRIPVLCYGLRTDFRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDA
HGHAVQDGPQVEIGGNERYVSVSRAEFKKIMRGEGRIDPLQIALPLPVA
>Mature_208_residues
AKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTLILTPKLDHRAGSGVVASRIGLRADGRIFERDTELQQLVERDIHNDGA
LHCVLVDEAQFLSRAQVWQLSEVVDRLRIPVLCYGLRTDFRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDAH
GHAVQDGPQVEIGGNERYVSVSRAEFKKIMRGEGRIDPLQIALPLPVA

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=192, Percent_Identity=60.4166666666667, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_XANAC (Q8PEQ8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644581.1
- ProteinModelPortal:   Q8PEQ8
- SMR:   Q8PEQ8
- GeneID:   1158353
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC4282
- NMPDR:   fig|190486.1.peg.4225
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- ProtClustDB:   PRK04296
- BioCyc:   XAXO190486:XAC4282-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 23480; Mature: 23349

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTLILTPKLDHRAGSGVVASRIGLRADGR
CCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCE
IFERDTELQQLVERDIHNDGALHCVLVDEAQFLSRAQVWQLSEVVDRLRIPVLCYGLRTD
EEECCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
FRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDAHGHAVQDGPQVEIGGNERYV
CCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEECCCCEEE
SVSRAEFKKIMRGEGRIDPLQIALPLPVA
EEHHHHHHHHHCCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
AKLYFYYSAMNAGKTTTLLQSAHNYRERGMRTLILTPKLDHRAGSGVVASRIGLRADGR
CEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCE
IFERDTELQQLVERDIHNDGALHCVLVDEAQFLSRAQVWQLSEVVDRLRIPVLCYGLRTD
EEECCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
FRGELFEGSQFLLAWADELEEIKTICHSGSKATMTVRVDAHGHAVQDGPQVEIGGNERYV
CCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEECCCCEEE
SVSRAEFKKIMRGEGRIDPLQIALPLPVA
EEHHHHHHHHHCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217