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The map label for this gene is exuT [H]

Identifier: 21244972

GI number: 21244972

Start: 5021696

End: 5023186

Strand: Reverse

Name: exuT [H]

Synonym: XAC4255

Alternate gene names: 21244972

Gene position: 5023186-5021696 (Counterclockwise)

Preceding gene: 21244977

Following gene: 21244971

Centisome position: 97.06

GC content: 64.79

Gene sequence:

>1491_bases
ATGATAGCGCTATCATCCGTGGCGCAAGGCCACCTTCGTGCAGGTGCAGTGGTCGATGAATCGAACCGAAGAACACGGCA
GCGATGGGTCCGGCCGGCACCTGATGGATGCATGCATGCACCACATCAGCCAGGCCGCCGGCGCGCTGGCGCGGTTGCAC
AGGCCGCGCGCATGAGCAACGTGCCCACCGCAGCGCCGGAGGCTGCATCGGCAAGGCTCGGCCGGGTGCGCTGGCGGGTT
TGCGCCTTGCTGCTGGCCGCCACCACCATCAACTATGTGGATCGCCAGGTACTGGGCGTGCTGGCGCCGTTCCTGCAGAC
GCAGATCGGTTGGAACGAAATCCAGTACGGCTATATCGTCACCGCATTCCAGGCGGCGTATGCGCTGGGTCTGCTGTGCA
GCGGTGCGGTGATCGACCGCTTCGGCACGCGGCTCGGCTATGCGCTGGCGATCGGCCTCTGGAGCCTGGCGGCGATGGGG
CATGCCCTGGCCACCAGCGTGGTGGGGTTTGCGATTGCGCGGTTTTTCCTGGGCCTTGGCGAATCGGGCAATTTTCCTGC
AGCGCTCAAGACGGTAGCCGAATGGTTCCCGCGCCGTGAGCGTGCGCTGGCCACCGGCATCTTCAATTCCGGCTCCAATA
TCGGGGCCATTGTCGCCCCGTTGCTGGTGCCGTTGATTGCCACAGCCTGGGGCTGGCAGGCGGCATTCCTGTTCACCGGC
GTGCTCAGTGCAACCTGGTTGGCGGTGTGGTGGTTCAGCTATCACCCGCCCGAGCAACAACCCCGTTTGTCTGCCGCAGA
ACTGGCGTATATCCGCAGCGATGCGCATGAGCCGGTGCAACGCCGGCTGTCGTGGTTACAGGTGCTGCGACATCGGCAAG
CCTGGGCGTTTGTGCTGGGCAAGTTCATCACCGACCCGATCTGGTGGTTCTTCCTGTTCTGGCTGCCGAAGTTCCTGCAC
GCCGAATACGACTTGAGCCTGCTGCAATTGGGCGTGCCCCTGATCGTGATCTTCGTGCTGGCCGACATCGGCAGCATTGC
CGGCGGTTGGGTGGCCGGGCGTTTCATCGCGCGTGGCTGGAGCGTCAACCGCGCACGCAAGACCGCGATGTTGATCTGCG
CGATTTCGGTGGTGCCCATCGTATTTGCCGCACGCGCCGACAACCTGTGGCTGGCGGTCGCGCTGATCGGGCTGGCCACC
GCCGCACATCAGGGCTGGTCGGCGAATCTGTTTACGCTGCCTTCGGACATGTTTCCGCGCCACGCGGTCGCCACGGTGGT
GGGTATCGGCGGCTTTGCCGGTGCGGTGGGCGGCATGTTGATCGCCACCTTCATCGGCTTCCTGTTGCAAGCGACCGGCA
GCTATGTGCCGGTGTTTCTGATGGCAGGCTCCGCCTACCTGCTGGCATTGGCGCTCGTGCACACTCTGGTGCCGCGGCTG
GAGCCGGCGCAGTTGCCTGCCGATCCCAGCGCCGACATCGTCCTGAGGTGA

Upstream 100 bases:

>100_bases
CCGGCAGGCCGCCAGCCAACCCACGCCATCGTGCCAGACTCGCTTGCGTACGGTGGCGCAGTGCTGCACTGCGCGATGGA
TTTATCGCGATGCCGTGGTA

Downstream 100 bases:

>100_bases
GCTTATGCACATGCGCGCAGTAATACTGGGGTTGTCGATGGCGGCCGGCATGGCCGCGCCTGTACACGCGGCACCACTGG
CAGCGACAGCGTCCAAGTTC

Product: hexuranate transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MIALSSVAQGHLRAGAVVDESNRRTRQRWVRPAPDGCMHAPHQPGRRRAGAVAQAARMSNVPTAAPEAASARLGRVRWRV
CALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIVTAFQAAYALGLLCSGAVIDRFGTRLGYALAIGLWSLAAMG
HALATSVVGFAIARFFLGLGESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAIVAPLLVPLIATAWGWQAAFLFTG
VLSATWLAVWWFSYHPPEQQPRLSAAELAYIRSDAHEPVQRRLSWLQVLRHRQAWAFVLGKFITDPIWWFFLFWLPKFLH
AEYDLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGWSVNRARKTAMLICAISVVPIVFAARADNLWLAVALIGLAT
AAHQGWSANLFTLPSDMFPRHAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVPVFLMAGSAYLLALALVHTLVPRL
EPAQLPADPSADIVLR

Sequences:

>Translated_496_residues
MIALSSVAQGHLRAGAVVDESNRRTRQRWVRPAPDGCMHAPHQPGRRRAGAVAQAARMSNVPTAAPEAASARLGRVRWRV
CALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIVTAFQAAYALGLLCSGAVIDRFGTRLGYALAIGLWSLAAMG
HALATSVVGFAIARFFLGLGESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAIVAPLLVPLIATAWGWQAAFLFTG
VLSATWLAVWWFSYHPPEQQPRLSAAELAYIRSDAHEPVQRRLSWLQVLRHRQAWAFVLGKFITDPIWWFFLFWLPKFLH
AEYDLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGWSVNRARKTAMLICAISVVPIVFAARADNLWLAVALIGLAT
AAHQGWSANLFTLPSDMFPRHAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVPVFLMAGSAYLLALALVHTLVPRL
EPAQLPADPSADIVLR
>Mature_496_residues
MIALSSVAQGHLRAGAVVDESNRRTRQRWVRPAPDGCMHAPHQPGRRRAGAVAQAARMSNVPTAAPEAASARLGRVRWRV
CALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIVTAFQAAYALGLLCSGAVIDRFGTRLGYALAIGLWSLAAMG
HALATSVVGFAIARFFLGLGESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAIVAPLLVPLIATAWGWQAAFLFTG
VLSATWLAVWWFSYHPPEQQPRLSAAELAYIRSDAHEPVQRRLSWLQVLRHRQAWAFVLGKFITDPIWWFFLFWLPKFLH
AEYDLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGWSVNRARKTAMLICAISVVPIVFAARADNLWLAVALIGLAT
AAHQGWSANLFTLPSDMFPRHAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVPVFLMAGSAYLLALALVHTLVPRL
EPAQLPADPSADIVLR

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=381, Percent_Identity=25.4593175853018, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI6912666, Length=342, Percent_Identity=24.5614035087719, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI21322234, Length=419, Percent_Identity=23.3890214797136, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI148743791, Length=329, Percent_Identity=22.7963525835866, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI9966811, Length=388, Percent_Identity=22.4226804123711, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI9945322, Length=358, Percent_Identity=22.9050279329609, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367193, Length=422, Percent_Identity=33.4123222748815, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082320, Length=420, Percent_Identity=30.2380952380952, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI1789515, Length=431, Percent_Identity=28.0742459396752, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789152, Length=445, Percent_Identity=26.2921348314607, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI2367379, Length=438, Percent_Identity=26.9406392694064, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87082231, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082404, Length=361, Percent_Identity=24.0997229916898, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082071, Length=384, Percent_Identity=23.1770833333333, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533556, Length=395, Percent_Identity=26.0759493670886, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI115533554, Length=401, Percent_Identity=25.6857855361596, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17535049, Length=427, Percent_Identity=21.7798594847775, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552542, Length=290, Percent_Identity=28.9655172413793, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32565914, Length=379, Percent_Identity=22.1635883905013, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI32565916, Length=247, Percent_Identity=25.9109311740891, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71991448, Length=405, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71991453, Length=405, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560030, Length=216, Percent_Identity=24.0740740740741, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17566884, Length=198, Percent_Identity=25.2525252525253, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193205400, Length=236, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583789, Length=355, Percent_Identity=25.0704225352113, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24584153, Length=349, Percent_Identity=23.7822349570201, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648416, Length=368, Percent_Identity=24.4565217391304, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356189, Length=368, Percent_Identity=24.4565217391304, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19920686, Length=395, Percent_Identity=22.0253164556962, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24580790, Length=295, Percent_Identity=23.728813559322, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641682, Length=386, Percent_Identity=23.0569948186528, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639764, Length=336, Percent_Identity=25.5952380952381, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573708, Length=410, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573707, Length=410, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62484226, Length=341, Percent_Identity=24.3401759530792, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573299, Length=241, Percent_Identity=26.1410788381743, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653727, Length=400, Percent_Identity=23.5, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53674; Mature: 53674

Theoretical pI: Translated: 10.80; Mature: 10.80

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALSSVAQGHLRAGAVVDESNRRTRQRWVRPAPDGCMHAPHQPGRRRAGAVAQAARMSN
CCCCHHHHHHHHHCCCEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
VPTAAPEAASARLGRVRWRVCALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TAFQAAYALGLLCSGAVIDRFGTRLGYALAIGLWSLAAMGHALATSVVGFAIARFFLGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAIVAPLLVPLIATAWGWQAAFLFTG
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
VLSATWLAVWWFSYHPPEQQPRLSAAELAYIRSDAHEPVQRRLSWLQVLRHRQAWAFVLG
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KFITDPIWWFFLFWLPKFLHAEYDLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGW
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SVNRARKTAMLICAISVVPIVFAARADNLWLAVALIGLATAAHQGWSANLFTLPSDMFPR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCH
HAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVPVFLMAGSAYLLALALVHTLVPRL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EPAQLPADPSADIVLR
CCCCCCCCCCCCCEEC
>Mature Secondary Structure
MIALSSVAQGHLRAGAVVDESNRRTRQRWVRPAPDGCMHAPHQPGRRRAGAVAQAARMSN
CCCCHHHHHHHHHCCCEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
VPTAAPEAASARLGRVRWRVCALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TAFQAAYALGLLCSGAVIDRFGTRLGYALAIGLWSLAAMGHALATSVVGFAIARFFLGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAIVAPLLVPLIATAWGWQAAFLFTG
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
VLSATWLAVWWFSYHPPEQQPRLSAAELAYIRSDAHEPVQRRLSWLQVLRHRQAWAFVLG
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KFITDPIWWFFLFWLPKFLHAEYDLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGW
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SVNRARKTAMLICAISVVPIVFAARADNLWLAVALIGLATAAHQGWSANLFTLPSDMFPR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCH
HAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVPVFLMAGSAYLLALALVHTLVPRL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EPAQLPADPSADIVLR
CCCCCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]