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The map label for this gene is kefC [H]

Identifier: 21244797

GI number: 21244797

Start: 4780372

End: 4782204

Strand: Direct

Name: kefC [H]

Synonym: XAC4080

Alternate gene names: 21244797

Gene position: 4780372-4782204 (Clockwise)

Preceding gene: 21244796

Following gene: 21244803

Centisome position: 92.36

GC content: 65.79

Gene sequence:

>1833_bases
ATGCCTCAATGGAGAGTACGCATGCATAGCGGTGGTCTGGAACTGGCCTTGGTGCTGATGCTGGCCGCCATCGTGGCAGT
GCCGGTGTTCAAGCGCTTCGGCCTGGGCGCGGTGTTGGCCTACCTGGTCGCCGGCGTGGTGCTCGGGCCCGATGGCGCGG
GTGTCGTGCAGGATGCCGAACGCATCAGCGGCGCGGCCGAGATCGGCGTGGTGATGCTGCTGTTCGTGATCGGGCTGGAA
CTGTCGCCGGCGCGTCTGAAGGTGATGCGCCATTCGGTGTTCGGCGCTGGCGCCACCCAGGTGCTGGTGACGGCGGTGAT
CCTGGGCGGTTTGTTGATGGCAGCCCAGCTGGGCTGGAAGAGCGCGTTGATCGTCGGCGTGGCGCTGGCGCTTTCATCCA
CCGCGGTGGGGCTGCAATTGCTGGCCGAACGCAAGGCGCTGAGCAGCGACTACGGACGGCTGGCGTTTGCCATTTTGCTG
TTCCAGGATTTGATTGCGATCCCGTTGCTGGCGGCCATCCCGTTGCTCGGCGGCAGCAAGAACGCAACGCTCCAATGGCA
GGACGTGGCCAAGGCGGTGGCGGCCCTGGCGCTGGTGATCGTGTGCGGGCGCTTTGTGTTGCGTCACCTGTTCAACGTGG
TGGCGCGTACGCGCATGCCGGAAGTGTTCACCGCCAGCGCCTTGCTGGTGGTGCTGGGCACCGCCTGGATCATGCAGGAG
GCCGGACTGAGCGCCAGCCTGGGCGCCTTCATCGCCGGCGTGTTGCTGGCCGATTCGGAGTTCCGCCACGAACTGGAATC
GCAGATCGAACCGTTCGAAGGCTTGCTGCTGGGCCTGTTCTTCATCTCGGTGGGCATGGGGATCGATCTCCACCGCGTGG
TGGCCGAGCCGTGGTTGATCGCAGCGGGCGTGGCGATATTGCTGGTGGTGAAGTTCTCGCTGCTGGTCGGCATCGGCAGC
GTGGCCAAGCTGCCGCTGCGCAGCAGCCTGATGCTGGGCAGCGTGCTGTGGCTGGGCGGCGAATTCGCCTTCGTGGTGTT
CAACGAAGCCGACCGCGTGGGCCTGCTGGAACCGGCCAATCACGATCGGCTGGTGGCCATCGTCGGCGTGTCGATGGCAT
TGACCCCGCTGTTGCTGCTGGGCATGCAACGCATCCTCAACGGACCGCTGCGTGCGCGCGCACCCAAGACCGATCGCCCG
TTCGACACCATCGATGCGCAGACCCCCAAGGTGCTGGTCGCCGGCATGGGCCGCTTCGGCCAGGTGGTCGCGCGCCTGCT
CACCGCACGGCATGTGCCGTTCGTGGCGCTGGAACACAACCCCGACACGGTGGAAGACCTGCGTCGGTTCGGCAGCCAGC
TCTATTACGGCGATCCCACCCGTCCCGAGCTGCTGCGCGCTGCCGGTGCCGAGCGCATCAAGGTGTTCGTGATCGCGGTG
GACGACCCGGAAACCAACATCAAGACGGTGCGACTGATCCGTCGCCTGTACCCGCAAGCCACCGTGCTGGCGCGTGCACG
CAACCGCCAACACGCCTGGAAATTGATGGACCTGGGCGCAGAACCGTTCCGCGAGGTATTCGCCTCCAGCCTGGAGCTGA
GCGAGCGCGTACTCACCTCGCTCGGCCTGGGCGAAGCCCTCGCACACGATCACGTCAAACGCTTCCGCCAGCACGACGAA
GACCTGCTGCGCCGCCAGCACCTGGTCTACGACGACGAAGCCAAGGTCATCCAGACCTCGCGCGATGCACGTGCCGACCT
GATGAACCTGTTCGAAGCCGACGTCAGGGCGGATGTGGATGGGGAACCTGCACCCACCCTGCGGGAACGTTGA

Upstream 100 bases:

>100_bases
GCCGCAGATAGGTGCCGGGCCGCATCGCGCAGCCGCGCATCGCCGCCGTGCAGATGGCACACGCGTGCGCGCAGGCCAAC
GGACCTGCGCGGCATAATGC

Downstream 100 bases:

>100_bases
GCTCTTCCGTAGGAGCGCGCCTGCGCGCGACCAGGTGTTTACCGGCAGAGTCCCGTCGCGCGCGGGCACGCTCCTACGCG
GATGTGGTGCACCGGTCGTC

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MPQWRVRMHSGGLELALVLMLAAIVAVPVFKRFGLGAVLAYLVAGVVLGPDGAGVVQDAERISGAAEIGVVMLLFVIGLE
LSPARLKVMRHSVFGAGATQVLVTAVILGGLLMAAQLGWKSALIVGVALALSSTAVGLQLLAERKALSSDYGRLAFAILL
FQDLIAIPLLAAIPLLGGSKNATLQWQDVAKAVAALALVIVCGRFVLRHLFNVVARTRMPEVFTASALLVVLGTAWIMQE
AGLSASLGAFIAGVLLADSEFRHELESQIEPFEGLLLGLFFISVGMGIDLHRVVAEPWLIAAGVAILLVVKFSLLVGIGS
VAKLPLRSSLMLGSVLWLGGEFAFVVFNEADRVGLLEPANHDRLVAIVGVSMALTPLLLLGMQRILNGPLRARAPKTDRP
FDTIDAQTPKVLVAGMGRFGQVVARLLTARHVPFVALEHNPDTVEDLRRFGSQLYYGDPTRPELLRAAGAERIKVFVIAV
DDPETNIKTVRLIRRLYPQATVLARARNRQHAWKLMDLGAEPFREVFASSLELSERVLTSLGLGEALAHDHVKRFRQHDE
DLLRRQHLVYDDEAKVIQTSRDARADLMNLFEADVRADVDGEPAPTLRER

Sequences:

>Translated_610_residues
MPQWRVRMHSGGLELALVLMLAAIVAVPVFKRFGLGAVLAYLVAGVVLGPDGAGVVQDAERISGAAEIGVVMLLFVIGLE
LSPARLKVMRHSVFGAGATQVLVTAVILGGLLMAAQLGWKSALIVGVALALSSTAVGLQLLAERKALSSDYGRLAFAILL
FQDLIAIPLLAAIPLLGGSKNATLQWQDVAKAVAALALVIVCGRFVLRHLFNVVARTRMPEVFTASALLVVLGTAWIMQE
AGLSASLGAFIAGVLLADSEFRHELESQIEPFEGLLLGLFFISVGMGIDLHRVVAEPWLIAAGVAILLVVKFSLLVGIGS
VAKLPLRSSLMLGSVLWLGGEFAFVVFNEADRVGLLEPANHDRLVAIVGVSMALTPLLLLGMQRILNGPLRARAPKTDRP
FDTIDAQTPKVLVAGMGRFGQVVARLLTARHVPFVALEHNPDTVEDLRRFGSQLYYGDPTRPELLRAAGAERIKVFVIAV
DDPETNIKTVRLIRRLYPQATVLARARNRQHAWKLMDLGAEPFREVFASSLELSERVLTSLGLGEALAHDHVKRFRQHDE
DLLRRQHLVYDDEAKVIQTSRDARADLMNLFEADVRADVDGEPAPTLRER
>Mature_609_residues
PQWRVRMHSGGLELALVLMLAAIVAVPVFKRFGLGAVLAYLVAGVVLGPDGAGVVQDAERISGAAEIGVVMLLFVIGLEL
SPARLKVMRHSVFGAGATQVLVTAVILGGLLMAAQLGWKSALIVGVALALSSTAVGLQLLAERKALSSDYGRLAFAILLF
QDLIAIPLLAAIPLLGGSKNATLQWQDVAKAVAALALVIVCGRFVLRHLFNVVARTRMPEVFTASALLVVLGTAWIMQEA
GLSASLGAFIAGVLLADSEFRHELESQIEPFEGLLLGLFFISVGMGIDLHRVVAEPWLIAAGVAILLVVKFSLLVGIGSV
AKLPLRSSLMLGSVLWLGGEFAFVVFNEADRVGLLEPANHDRLVAIVGVSMALTPLLLLGMQRILNGPLRARAPKTDRPF
DTIDAQTPKVLVAGMGRFGQVVARLLTARHVPFVALEHNPDTVEDLRRFGSQLYYGDPTRPELLRAAGAERIKVFVIAVD
DPETNIKTVRLIRRLYPQATVLARARNRQHAWKLMDLGAEPFREVFASSLELSERVLTSLGLGEALAHDHVKRFRQHDED
LLRRQHLVYDDEAKVIQTSRDARADLMNLFEADVRADVDGEPAPTLRER

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=356, Percent_Identity=25.8426966292135, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786232, Length=569, Percent_Identity=43.0579964850615, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789749, Length=590, Percent_Identity=40.8474576271186, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1786685, Length=550, Percent_Identity=27.6363636363636, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65995; Mature: 65864

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQWRVRMHSGGLELALVLMLAAIVAVPVFKRFGLGAVLAYLVAGVVLGPDGAGVVQDAE
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEECCCCCCHHHHHH
RISGAAEIGVVMLLFVIGLELSPARLKVMRHSVFGAGATQVLVTAVILGGLLMAAQLGWK
HHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHH
SALIVGVALALSSTAVGLQLLAERKALSSDYGRLAFAILLFQDLIAIPLLAAIPLLGGSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NATLQWQDVAKAVAALALVIVCGRFVLRHLFNVVARTRMPEVFTASALLVVLGTAWIMQE
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AGLSASLGAFIAGVLLADSEFRHELESQIEPFEGLLLGLFFISVGMGIDLHRVVAEPWLI
CCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCHHHH
AAGVAILLVVKFSLLVGIGSVAKLPLRSSLMLGSVLWLGGEFAFVVFNEADRVGLLEPAN
HHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
HDRLVAIVGVSMALTPLLLLGMQRILNGPLRARAPKTDRPFDTIDAQTPKVLVAGMGRFG
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHH
QVVARLLTARHVPFVALEHNPDTVEDLRRFGSQLYYGDPTRPELLRAAGAERIKVFVIAV
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEEE
DDPETNIKTVRLIRRLYPQATVLARARNRQHAWKLMDLGAEPFREVFASSLELSERVLTS
CCCCCCHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGLGEALAHDHVKRFRQHDEDLLRRQHLVYDDEAKVIQTSRDARADLMNLFEADVRADVD
HCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCC
GEPAPTLRER
CCCCCCCCCC
>Mature Secondary Structure 
PQWRVRMHSGGLELALVLMLAAIVAVPVFKRFGLGAVLAYLVAGVVLGPDGAGVVQDAE
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEECCCCCCHHHHHH
RISGAAEIGVVMLLFVIGLELSPARLKVMRHSVFGAGATQVLVTAVILGGLLMAAQLGWK
HHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHH
SALIVGVALALSSTAVGLQLLAERKALSSDYGRLAFAILLFQDLIAIPLLAAIPLLGGSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NATLQWQDVAKAVAALALVIVCGRFVLRHLFNVVARTRMPEVFTASALLVVLGTAWIMQE
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AGLSASLGAFIAGVLLADSEFRHELESQIEPFEGLLLGLFFISVGMGIDLHRVVAEPWLI
CCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCHHHH
AAGVAILLVVKFSLLVGIGSVAKLPLRSSLMLGSVLWLGGEFAFVVFNEADRVGLLEPAN
HHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
HDRLVAIVGVSMALTPLLLLGMQRILNGPLRARAPKTDRPFDTIDAQTPKVLVAGMGRFG
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHH
QVVARLLTARHVPFVALEHNPDTVEDLRRFGSQLYYGDPTRPELLRAAGAERIKVFVIAV
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEEE
DDPETNIKTVRLIRRLYPQATVLARARNRQHAWKLMDLGAEPFREVFASSLELSERVLTS
CCCCCCHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGLGEALAHDHVKRFRQHDEDLLRRQHLVYDDEAKVIQTSRDARADLMNLFEADVRADVD
HCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCC
GEPAPTLRER
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA