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The map label for this gene is ecaA [H]

Identifier: 21244796

GI number: 21244796

Start: 4779359

End: 4780174

Strand: Direct

Name: ecaA [H]

Synonym: XAC4079

Alternate gene names: 21244796

Gene position: 4779359-4780174 (Clockwise)

Preceding gene: 21244786

Following gene: 21244797

Centisome position: 92.34

GC content: 64.34

Gene sequence:

>816_bases
TTGCTACAGTCCGCTTCCCGCAACGCCTGGCGCGTTGCTTTTCCGCCATGGCATCGGCCATCGCATCCACGCAGTGCGTT
TTTTCTTCCGGAGTTTGTGCATGCCCGCTTCCAGGTCGCTTCTGTCACGTCGCATCAGCCCGCTGTGCCTGTGCATCGCC
GCCGGCTGGGGCGCGGTGGGCATGGCGCAAACCGCACTGCCCGAAAGCAAGCCGGTGGAGGCGCACGAGACCGCGCCGCA
TACCGCGCCATCGACGCCAACCTGGGCACGCTGCTGCTGAGCTACAGCGCCGTGCCGCTGGTCGTGCGCAACACCGGCCA
TTCCATCCAGCTGGATCTGCACGATGGCGGCAGCATGGCGACCGGCGGCAAGCAGTATCAAGCCTTGCAACTGCACTTCC
ATCACCCCAGCGAGCATCTGTTGAACGGCCGTCGTTTCCCGATGGAAGCGCACCTGGTGCATCAGGGCCCGGACGGAACG
CTGGGTGTGCTGGCGATCTTCTTCGAAACCGGCAAGGCCAACACGGCCTTCCAGCGGGTGCTCGACGCCATGCCCAAGGA
CAAGGATCAGACCCGGCAGGTCGCCAACGCGACGGTGAGCGCCGAGGCGTTTCTTCCGCCGAGCAATCAACGCAGCTTCT
ATCGCTACGAAGGCTCGCTGACCACGCCGCCGTGCAGCGAAACGGTGGACTGGGTGGTGCTCAGCCAGCCGGTGCAGGTC
TCGGAGGCGCAGATCAACGCATTCGAACGCGTGTACCCGTTCAATGCACGCCCACTGCAGCCGCTGGACCGGCGTTTTCT
GCTTAAAAGCCACTGA

Upstream 100 bases:

>100_bases
TTTTGGCGGATGCCGATGCACCGTTGCCGTGGCGGCGCTGGCCGCCGCGACAGCGCCGCGCAACCGCCTGTCGCCGCGCC
GTGCTGAGAGTCACACTTCA

Downstream 100 bases:

>100_bases
TTGCTCGCGCGGTGTGTCGACCGTGCGCGGCGTGTCACGCACCGCCTGCGCACCGACCGTGCGGGCGCGGGCGGTGCCGG
ACTGATCCGCGCACACAGCC

Product: a-type carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MLQSASRNAWRVAFPPWHRPSHPRSAFFLPEFVHARFQVASVTSHQPAVPVHRRRLGRGGHGANRTARKQAGGGARDRAA
YRAIDANLGTLLLSYSAVPLVVRNTGHSIQLDLHDGGSMATGGKQYQALQLHFHHPSEHLLNGRRFPMEAHLVHQGPDGT
LGVLAIFFETGKANTAFQRVLDAMPKDKDQTRQVANATVSAEAFLPPSNQRSFYRYEGSLTTPPCSETVDWVVLSQPVQV
SEAQINAFERVYPFNARPLQPLDRRFLLKSH

Sequences:

>Translated_271_residues
MLQSASRNAWRVAFPPWHRPSHPRSAFFLPEFVHARFQVASVTSHQPAVPVHRRRLGRGGHGANRTARKQAGGGARDRAA
YRAIDANLGTLLLSYSAVPLVVRNTGHSIQLDLHDGGSMATGGKQYQALQLHFHHPSEHLLNGRRFPMEAHLVHQGPDGT
LGVLAIFFETGKANTAFQRVLDAMPKDKDQTRQVANATVSAEAFLPPSNQRSFYRYEGSLTTPPCSETVDWVVLSQPVQV
SEAQINAFERVYPFNARPLQPLDRRFLLKSH
>Mature_271_residues
MLQSASRNAWRVAFPPWHRPSHPRSAFFLPEFVHARFQVASVTSHQPAVPVHRRRLGRGGHGANRTARKQAGGGARDRAA
YRAIDANLGTLLLSYSAVPLVVRNTGHSIQLDLHDGGSMATGGKQYQALQLHFHHPSEHLLNGRRFPMEAHLVHQGPDGT
LGVLAIFFETGKANTAFQRVLDAMPKDKDQTRQVANATVSAEAFLPPSNQRSFYRYEGSLTTPPCSETVDWVVLSQPVQV
SEAQINAFERVYPFNARPLQPLDRRFLLKSH

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4885101, Length=220, Percent_Identity=35.4545454545455, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI169636420, Length=209, Percent_Identity=36.3636363636364, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI62240989, Length=206, Percent_Identity=34.9514563106796, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4502519, Length=244, Percent_Identity=32.3770491803279, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502521, Length=222, Percent_Identity=31.981981981982, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4557395, Length=216, Percent_Identity=32.8703703703704, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI38348436, Length=217, Percent_Identity=30.8755760368664, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI45935383, Length=203, Percent_Identity=31.5270935960591, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4502515, Length=203, Percent_Identity=31.5270935960591, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI6005723, Length=216, Percent_Identity=31.4814814814815, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI22027500, Length=204, Percent_Identity=27.9411764705882, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI258679498, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI192447434, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI192447432, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI192447430, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4502517, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4885099, Length=201, Percent_Identity=30.3482587064677, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI194097398, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI70167127, Length=200, Percent_Identity=31.5, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI6912284, Length=205, Percent_Identity=30.2439024390244, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI91208428, Length=173, Percent_Identity=30.0578034682081, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI130979954, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI130979679, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI9910366, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568715, Length=175, Percent_Identity=40, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17569163, Length=137, Percent_Identity=33.5766423357664, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569165, Length=137, Percent_Identity=33.5766423357664, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71995280, Length=177, Percent_Identity=32.7683615819209, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17553578, Length=149, Percent_Identity=28.8590604026846, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21358169, Length=217, Percent_Identity=29.4930875576037, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650523, Length=285, Percent_Identity=29.8245614035088, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24645604, Length=166, Percent_Identity=31.3253012048193, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737413, Length=184, Percent_Identity=28.804347826087, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651619, Length=183, Percent_Identity=32.2404371584699, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI116008410, Length=231, Percent_Identity=29.004329004329, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161079350, Length=205, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130189, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 30146; Mature: 30146

Theoretical pI: Translated: 11.04; Mature: 11.04

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSASRNAWRVAFPPWHRPSHPRSAFFLPEFVHARFQVASVTSHQPAVPVHRRRLGRGG
CCCCCCCCEEEEECCCCCCCCCCCCEECCHHHHHHHEEEEECCCCCCCCCHHHHHCCCCC
HGANRTARKQAGGGARDRAAYRAIDANLGTLLLSYSAVPLVVRNTGHSIQLDLHDGGSMA
CCCCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCC
TGGKQYQALQLHFHHPSEHLLNGRRFPMEAHLVHQGPDGTLGVLAIFFETGKANTAFQRV
CCCCCEEEEEEEEECCHHHHHCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCCHHHHHH
LDAMPKDKDQTRQVANATVSAEAFLPPSNQRSFYRYEGSLTTPPCSETVDWVVLSQPVQV
HHHCCCCHHHHHHHHHCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCH
SEAQINAFERVYPFNARPLQPLDRRFLLKSH
HHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MLQSASRNAWRVAFPPWHRPSHPRSAFFLPEFVHARFQVASVTSHQPAVPVHRRRLGRGG
CCCCCCCCEEEEECCCCCCCCCCCCEECCHHHHHHHEEEEECCCCCCCCCHHHHHCCCCC
HGANRTARKQAGGGARDRAAYRAIDANLGTLLLSYSAVPLVVRNTGHSIQLDLHDGGSMA
CCCCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCC
TGGKQYQALQLHFHHPSEHLLNGRRFPMEAHLVHQGPDGTLGVLAIFFETGKANTAFQRV
CCCCCEEEEEEEEECCHHHHHCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCCHHHHHH
LDAMPKDKDQTRQVANATVSAEAFLPPSNQRSFYRYEGSLTTPPCSETVDWVVLSQPVQV
HHHCCCCHHHHHHHHHCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCH
SEAQINAFERVYPFNARPLQPLDRRFLLKSH
HHHHHHHHHHCCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9006032; 11759840 [H]