Click here to switch to the map view.

The map label for this gene is nucA [H]

Identifier: 21244754

GI number: 21244754

Start: 4729023

End: 4729880

Strand: Direct

Name: nucA [H]

Synonym: XAC4037

Alternate gene names: 21244754

Gene position: 4729023-4729880 (Clockwise)

Preceding gene: 21244752

Following gene: 21244756

Centisome position: 91.37

GC content: 64.22

Gene sequence:

>858_bases
TTGTCGGATGCGTTCTGCCTCGCCGTCATCTGCCGCACATGGCGCGGTCATCGTTCGGACATCGCGCATCGCCACCTTCC
TCACTCCCCTTGGCAAGCGAGCTCTGCAATGTCCTTCTTCCTGCGCGGTTGTGTGGCCCTGGCAGTGTTGTGCACGACCT
CCGTGGCGGCCGCCACGACCCGTTGTCCCACTCTTTACGCGAACGGCACCCCGCCTAGCGTGAGCAGCACGACCCGCACC
ACCGAGATCTGCCACACCGAATACGTGCTCCTGGCCTCGGGCGTGACCAAGGACCCGGCATATTCGGCCGAGCATCTCAC
CGACCAGCAGGTCGCCGGTGCCGAGGCGATCGGCCGGGTCGGCTCGTTTCACGATGAAACCGGCATTCCGGCCGCCGACC
GCTCCAAAAGCTCCGACTACACCAACACCGGCTACGACCGCGGGCACATGACGCCGGCCGGCGATGCATCGACCGAAAGC
TCGGAAAAAGAAACCTTTTCCATGGCCAACGTCGTCCCGCAGGACCACAAGCTCAACACCGGAGAGTGGGCGCACATCGA
AGAGCAGGTGCGTCAGCTGGCCAAGCAACACGGCGAGTTGTACGTGGTGACCGGCCCGGCGTTCGACAGCGGCACTGCAC
CGACCATCGGCACCGACAAGGTCGTCGTCCCGGCATATGTGTGGAAGGCGATCTATGAACCGGGCGTGGGCGCCGGCGCG
TATCTGTGCGTCAACGACAGCAGCATCAATTGCGACGTGGTGTCGATCGACGACCTCGTCGTGATGACCAACGTCGACCC
GTTCCCCTCGCTCAGCGCCAGCGTGAAGTCGCACGCGATCGCGCTGGTGCTGCCGTAA

Upstream 100 bases:

>100_bases
GCCGGCCATTGTAGATGAGAATGAGTCTCGCATCCGATCTGCATCGATGCCGATGGCGGCCCGCGTCCCGCTGCACGCCA
CGCACCGGAAACGGTCCGTC

Downstream 100 bases:

>100_bases
GGATGGCCACCTGTGCGTGCGGCGGTCGGCTGCATCGCGTCGCGCAGGCGGACATCGCACGCAAACGGCAAACGGACTCG
TTGATCGCAGCGGCTGGATG

Product: endonuclease

Products: NA

Alternate protein names: Endonuclease [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSDAFCLAVICRTWRGHRSDIAHRHLPHSPWQASSAMSFFLRGCVALAVLCTTSVAAATTRCPTLYANGTPPSVSSTTRT
TEICHTEYVLLASGVTKDPAYSAEHLTDQQVAGAEAIGRVGSFHDETGIPAADRSKSSDYTNTGYDRGHMTPAGDASTES
SEKETFSMANVVPQDHKLNTGEWAHIEEQVRQLAKQHGELYVVTGPAFDSGTAPTIGTDKVVVPAYVWKAIYEPGVGAGA
YLCVNDSSINCDVVSIDDLVVMTNVDPFPSLSASVKSHAIALVLP

Sequences:

>Translated_285_residues
MSDAFCLAVICRTWRGHRSDIAHRHLPHSPWQASSAMSFFLRGCVALAVLCTTSVAAATTRCPTLYANGTPPSVSSTTRT
TEICHTEYVLLASGVTKDPAYSAEHLTDQQVAGAEAIGRVGSFHDETGIPAADRSKSSDYTNTGYDRGHMTPAGDASTES
SEKETFSMANVVPQDHKLNTGEWAHIEEQVRQLAKQHGELYVVTGPAFDSGTAPTIGTDKVVVPAYVWKAIYEPGVGAGA
YLCVNDSSINCDVVSIDDLVVMTNVDPFPSLSASVKSHAIALVLP
>Mature_284_residues
SDAFCLAVICRTWRGHRSDIAHRHLPHSPWQASSAMSFFLRGCVALAVLCTTSVAAATTRCPTLYANGTPPSVSSTTRTT
EICHTEYVLLASGVTKDPAYSAEHLTDQQVAGAEAIGRVGSFHDETGIPAADRSKSSDYTNTGYDRGHMTPAGDASTESS
EKETFSMANVVPQDHKLNTGEWAHIEEQVRQLAKQHGELYVVTGPAFDSGTAPTIGTDKVVVPAYVWKAIYEPGVGAGAY
LCVNDSSINCDVVSIDDLVVMTNVDPFPSLSASVKSHAIALVLP

Specific function: Catalyzes the degradation of both RNA and DNA; has the potential to act as an endonuclease [H]

COG id: COG1864

COG function: function code F; DNA/RNA endonuclease G, NUC1

Gene ontology:

Cell location: Periplasm. Note=Periplasmic or loosely attached to the cytoplasmic or the outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA/RNA non-specific endonuclease family [H]

Homologues:

Organism=Homo sapiens, GI224451073, Length=217, Percent_Identity=29.4930875576037, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224451075, Length=173, Percent_Identity=31.2138728323699, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI53759134, Length=154, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17505967, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322253, Length=158, Percent_Identity=31.0126582278481, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129899, Length=195, Percent_Identity=32.3076923076923, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581065, Length=159, Percent_Identity=26.4150943396226, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018524
- InterPro:   IPR001604
- InterPro:   IPR020821 [H]

Pfam domain/function: PF01223 Endonuclease_NS [H]

EC number: NA

Molecular weight: Translated: 30358; Mature: 30227

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAFCLAVICRTWRGHRSDIAHRHLPHSPWQASSAMSFFLRGCVALAVLCTTSVAAATT
CCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCPTLYANGTPPSVSSTTRTTEICHTEYVLLASGVTKDPAYSAEHLTDQQVAGAEAIGRV
CCCEEEECCCCCCCCCCCCHHHHHHHEEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHH
GSFHDETGIPAADRSKSSDYTNTGYDRGHMTPAGDASTESSEKETFSMANVVPQDHKLNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GEWAHIEEQVRQLAKQHGELYVVTGPAFDSGTAPTIGTDKVVVPAYVWKAIYEPGVGAGA
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCE
YLCVNDSSINCDVVSIDDLVVMTNVDPFPSLSASVKSHAIALVLP
EEEEECCCCCEEEEEECCEEEEECCCCCCCCHHHHHHCEEEEEEC
>Mature Secondary Structure 
SDAFCLAVICRTWRGHRSDIAHRHLPHSPWQASSAMSFFLRGCVALAVLCTTSVAAATT
CCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCPTLYANGTPPSVSSTTRTTEICHTEYVLLASGVTKDPAYSAEHLTDQQVAGAEAIGRV
CCCEEEECCCCCCCCCCCCHHHHHHHEEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHH
GSFHDETGIPAADRSKSSDYTNTGYDRGHMTPAGDASTESSEKETFSMANVVPQDHKLNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GEWAHIEEQVRQLAKQHGELYVVTGPAFDSGTAPTIGTDKVVVPAYVWKAIYEPGVGAGA
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCE
YLCVNDSSINCDVVSIDDLVVMTNVDPFPSLSASVKSHAIALVLP
EEEEECCCCCEEEEEECCEEEEECCCCCCCCHHHHHHCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1343821; 11759840 [H]