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The map label for this gene is pepA [H]

Identifier: 21244705

GI number: 21244705

Start: 4678747

End: 4680129

Strand: Direct

Name: pepA [H]

Synonym: XAC3987

Alternate gene names: 21244705

Gene position: 4678747-4680129 (Clockwise)

Preceding gene: 21244704

Following gene: 21244708

Centisome position: 90.4

GC content: 68.26

Gene sequence:

>1383_bases
TTGAGGATTTCCATGTCCCATCTCACCGGTTTCATCGATCCCAACGCCGCAGCCTTGCCGCTGTATGTGCTCGACCGCGA
AGGCTTTACGCGCTGGTGCGCGGAGCAGCCCACCCGCGTGCTGTCGTGGGCGCAGGCCCAGCGTTTCGATGCCGCGCCGG
GCAGCGTGCTGTTGTTGCCGGGCGACAACGGGCTGGCCGGGGCGATCCTGGGTATCGGCGACCGGGCCGATGCCTACGCC
TACGCGCATGCGCCGATGGCCTTACCGCCGGCCACCCGCTGGATGCTGGCCAACCCGCTGAGCGATGCCGAGCAGGCGTT
GCTGCATCTGGGCTGGGGATTGGGCGCCTATCGCTTTTCGCGTTATCGCAAGGTGCCGCGCGCGCCGGCCGAACTGGCTG
CAACGCCATCGGCACAGACGCGTACGCTGATCGAGGCGTGCCTGCAGGTACGCGACTGGGTCAACACGCCCACCGAAGAC
ATGGGCCCGCAGCATCTGGAAGAGGCCACACGCACGCTGGGACAGGCGCATGGCGCACAGGTCGATGCGATCGTCGGCGA
CGCGTTGCTGGCGCAGAACTTCCCCACCATCCATGCCGTGGGGCGCGCCTCGCATCGCGCGCCGCGACTGATCCAGTTGC
AATGGGGCGACACGGCGCATCCGCATCTGGTGCTGGTCGGCAAGGGCGTGTGCTTCGACACCGGCGGGCTGGATCTGAAG
CCGGCCGATGGCATGCGCAACATGAAAAAGGACATGGGCGGCGCGGCGCATGCCTTGGCGCTGGCCGGATTGGTGATGGC
GCAGCAGTTGCCGGTGCGGCTGACGCTGCTGATTGCGGCAGTGGAGAACGCGGTGGGCCCGGATGCATTCCGCCCTGGCG
AAGTGATCACCACCCGCGCCGGCGTGTCGGTGGAAGTGGACAACACCGATGCAGAAGGGCGCCTGGTGCTGTGCGATGCG
CTGAGCTATGCGACCGAGCAGCACCCGGATCTGATCCTGGATTTCGCCACGCTCACCGGCGCGGCACGCATCGCGCTGGG
CCCGGACCTGCCGGCGCTCTTCGCCAACGACGATGCGCTGGCGCAGGCCTGGATCAGTGCCGGCGAACTGACCCGCGACC
CGGTGTGGCGCATGCCGCTCTGGCGCCCTTACCTGCGTTATCTCAATAGCCATGTGGCCGACATGGCCAACGCCGGCTCG
CGCATGGCCGGCGCCGTCACCGCCGCGCTGTATCTGGAACGCTTCGTGGCACCCGGACAGCCGTGGGCGCATCTGGACGT
CTACGCCTGGAACGACAGCGACCGCCCTGGCCGCCCTGCCGGCGGCGAAGCGCTGGCAGTGCGCTCGGCGTTCGCGATGC
TGCAGCAACGCTACGGCGGTTGA

Upstream 100 bases:

>100_bases
ACCGGGCTGGCCGATTGGCTGGACGCGCAGCAGCCGCATCCGGGCCCTATGAACGCCGGCATCACCCTTCCCGCCTGAGC
CACTGCGCGCGGCGCTGCAC

Downstream 100 bases:

>100_bases
GCGCGGCGAGCGCTGCTGTCAGTCTGAGGCGAGCACAACTCGCCTTCAGCTGCGCTGGTCATCCCTGGCGACGCAACAAC
GGCGCGATCGTGCGCATGCG

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MRISMSHLTGFIDPNAAALPLYVLDREGFTRWCAEQPTRVLSWAQAQRFDAAPGSVLLLPGDNGLAGAILGIGDRADAYA
YAHAPMALPPATRWMLANPLSDAEQALLHLGWGLGAYRFSRYRKVPRAPAELAATPSAQTRTLIEACLQVRDWVNTPTED
MGPQHLEEATRTLGQAHGAQVDAIVGDALLAQNFPTIHAVGRASHRAPRLIQLQWGDTAHPHLVLVGKGVCFDTGGLDLK
PADGMRNMKKDMGGAAHALALAGLVMAQQLPVRLTLLIAAVENAVGPDAFRPGEVITTRAGVSVEVDNTDAEGRLVLCDA
LSYATEQHPDLILDFATLTGAARIALGPDLPALFANDDALAQAWISAGELTRDPVWRMPLWRPYLRYLNSHVADMANAGS
RMAGAVTAALYLERFVAPGQPWAHLDVYAWNDSDRPGRPAGGEALAVRSAFAMLQQRYGG

Sequences:

>Translated_460_residues
MRISMSHLTGFIDPNAAALPLYVLDREGFTRWCAEQPTRVLSWAQAQRFDAAPGSVLLLPGDNGLAGAILGIGDRADAYA
YAHAPMALPPATRWMLANPLSDAEQALLHLGWGLGAYRFSRYRKVPRAPAELAATPSAQTRTLIEACLQVRDWVNTPTED
MGPQHLEEATRTLGQAHGAQVDAIVGDALLAQNFPTIHAVGRASHRAPRLIQLQWGDTAHPHLVLVGKGVCFDTGGLDLK
PADGMRNMKKDMGGAAHALALAGLVMAQQLPVRLTLLIAAVENAVGPDAFRPGEVITTRAGVSVEVDNTDAEGRLVLCDA
LSYATEQHPDLILDFATLTGAARIALGPDLPALFANDDALAQAWISAGELTRDPVWRMPLWRPYLRYLNSHVADMANAGS
RMAGAVTAALYLERFVAPGQPWAHLDVYAWNDSDRPGRPAGGEALAVRSAFAMLQQRYGG
>Mature_460_residues
MRISMSHLTGFIDPNAAALPLYVLDREGFTRWCAEQPTRVLSWAQAQRFDAAPGSVLLLPGDNGLAGAILGIGDRADAYA
YAHAPMALPPATRWMLANPLSDAEQALLHLGWGLGAYRFSRYRKVPRAPAELAATPSAQTRTLIEACLQVRDWVNTPTED
MGPQHLEEATRTLGQAHGAQVDAIVGDALLAQNFPTIHAVGRASHRAPRLIQLQWGDTAHPHLVLVGKGVCFDTGGLDLK
PADGMRNMKKDMGGAAHALALAGLVMAQQLPVRLTLLIAAVENAVGPDAFRPGEVITTRAGVSVEVDNTDAEGRLVLCDA
LSYATEQHPDLILDFATLTGAARIALGPDLPALFANDDALAQAWISAGELTRDPVWRMPLWRPYLRYLNSHVADMANAGS
RMAGAVTAALYLERFVAPGQPWAHLDVYAWNDSDRPGRPAGGEALAVRSAFAMLQQRYGG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=341, Percent_Identity=33.4310850439883, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI47155554, Length=284, Percent_Identity=35.9154929577465, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1790710, Length=316, Percent_Identity=38.6075949367089, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=40.1898734177215, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=298, Percent_Identity=36.5771812080537, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=32.5301204819277, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355725, Length=280, Percent_Identity=34.6428571428571, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24661038, Length=280, Percent_Identity=34.2857142857143, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21357381, Length=285, Percent_Identity=35.0877192982456, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221379063, Length=285, Percent_Identity=35.0877192982456, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221379062, Length=285, Percent_Identity=35.0877192982456, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20129969, Length=344, Percent_Identity=30.2325581395349, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24662227, Length=314, Percent_Identity=30.8917197452229, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21355645, Length=318, Percent_Identity=29.2452830188679, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24662223, Length=318, Percent_Identity=29.2452830188679, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19922386, Length=323, Percent_Identity=28.7925696594427, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161077148, Length=457, Percent_Identity=25.382932166302, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20130057, Length=457, Percent_Identity=25.382932166302, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129963, Length=329, Percent_Identity=27.9635258358663, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646701, Length=206, Percent_Identity=37.8640776699029, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646703, Length=206, Percent_Identity=37.8640776699029, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21358201, Length=206, Percent_Identity=37.8640776699029, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49381; Mature: 49381

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISMSHLTGFIDPNAAALPLYVLDREGFTRWCAEQPTRVLSWAQAQRFDAAPGSVLLLP
CEEEHHHHCEECCCCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEE
GDNGLAGAILGIGDRADAYAYAHAPMALPPATRWMLANPLSDAEQALLHLGWGLGAYRFS
CCCCCEEEEEECCCCCCCEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCHHHHHHH
RYRKVPRAPAELAATPSAQTRTLIEACLQVRDWVNTPTEDMGPQHLEEATRTLGQAHGAQ
HHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCE
VDAIVGDALLAQNFPTIHAVGRASHRAPRLIQLQWGDTAHPHLVLVGKGVCFDTGGLDLK
EHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCC
PADGMRNMKKDMGGAAHALALAGLVMAQQLPVRLTLLIAAVENAVGPDAFRPGEVITTRA
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECC
GVSVEVDNTDAEGRLVLCDALSYATEQHPDLILDFATLTGAARIALGPDLPALFANDDAL
CEEEEECCCCCCCCEEEEEHHHHHHCCCCCCEEEHHHHCCCEEEEECCCCCEEECCCHHH
AQAWISAGELTRDPVWRMPLWRPYLRYLNSHVADMANAGSRMAGAVTAALYLERFVAPGQ
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PWAHLDVYAWNDSDRPGRPAGGEALAVRSAFAMLQQRYGG
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRISMSHLTGFIDPNAAALPLYVLDREGFTRWCAEQPTRVLSWAQAQRFDAAPGSVLLLP
CEEEHHHHCEECCCCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEE
GDNGLAGAILGIGDRADAYAYAHAPMALPPATRWMLANPLSDAEQALLHLGWGLGAYRFS
CCCCCEEEEEECCCCCCCEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCHHHHHHH
RYRKVPRAPAELAATPSAQTRTLIEACLQVRDWVNTPTEDMGPQHLEEATRTLGQAHGAQ
HHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCE
VDAIVGDALLAQNFPTIHAVGRASHRAPRLIQLQWGDTAHPHLVLVGKGVCFDTGGLDLK
EHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCC
PADGMRNMKKDMGGAAHALALAGLVMAQQLPVRLTLLIAAVENAVGPDAFRPGEVITTRA
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECC
GVSVEVDNTDAEGRLVLCDALSYATEQHPDLILDFATLTGAARIALGPDLPALFANDDAL
CEEEEECCCCCCCCEEEEEHHHHHHCCCCCCEEEHHHHCCCEEEEECCCCCEEECCCHHH
AQAWISAGELTRDPVWRMPLWRPYLRYLNSHVADMANAGSRMAGAVTAALYLERFVAPGQ
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PWAHLDVYAWNDSDRPGRPAGGEALAVRSAFAMLQQRYGG
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA