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The map label for this gene is htrA [H]

Identifier: 21244698

GI number: 21244698

Start: 4673409

End: 4674845

Strand: Direct

Name: htrA [H]

Synonym: XAC3980

Alternate gene names: 21244698

Gene position: 4673409-4674845 (Clockwise)

Preceding gene: 21244695

Following gene: 21244699

Centisome position: 90.3

GC content: 65.9

Gene sequence:

>1437_bases
ATGCGACCGCTGCCTACCCTGCTGACTCTTTCGCTGGCCGCTGCCTTCGGCGGCTTTGCCGCCACCGGCATCAACGCCTG
GCTCGACAATCGCGCCGAAGCCACACCCCCCAGCAACGCCGCCTTTACCCTGCCGACGGCCGCCGCATTGCCGGCGGCGG
TGGCCGGCCAACCTGTGCCGTCGCTGGCGCCGATGCTGCAGCAGGCCATGCCCGCGGTGGTGAGCGTGAACACCAAACAG
GTGGTGCGCGTCCGCAACCCGTTCTTCAACGACCCGATCCTGCGCCGGCTGTTTCCGCAGGTGCCGCAGGACCGCATCAA
CGAGTCGCTGGGTTCGGGCGTGATCATCGATGCGCAAAAAGGGTATGTGCTGACCAATCACCACGTCATCGAAAACGCCG
ACGACGTGCAGGTGACGCTCGGCGACGGACGCACGGTCAAGGCCGAGTTCATCGGCTCCGATGCCGATACCGATATTGCG
CTGATCCGCATCAAGGCCGACAACCTCACCGATATCAAACTGGCCGACAGCAACGCGCTACGCGTGGGCGATTTTGTGGT
GGCCATCGGCAACCCGTTCGGCTTCACCCAGACCGTCACCTCCGGCATCGTCTCGGCAGTGGGGCGCAGCGGGATTCGCG
GCTTGGGCTACCAGAACTTCATCCAGACCGATGCCTCGATCAACCCCGGCAACTCGGGCGGCGCGCTGGTCAACCTGCAA
GGCCAGTTGGTTGGCATCAACACCGCCAGCTTCAATCCGCAGGGCAGCATGGCCGGCAATATCGGCCTGGGGCTGGCGAT
TCCGTCCAACCTGGCGCGCAATGTCGTCGAGCAATTGGTGACCAAGGGCGTGGTGGTGCGCGGCACGCTCGGCCTGGAGA
CCCAGAACCTCACCCAACAGATGCTGCAGGGCCTGGGGGTGGATTCGTTGCGCGGCGCATTGGTGACACGGGTGTTGCCG
GGCTCCGCAGCGGCGGCGGCAGGCGTGCAACCGGGCGATGTCGTGGTGGCGGCCAACGACCAGCGCGTGGACAGCGCCGA
AGCGCTGCACAACTACGAAGGCCTGCAGGCGGTTGGCAGTGCGGTGACCCTGGATATCCGTCGCGATGGCAAGCCGCTCA
AACTCAAGGCCACGCTGAGAGAGCAGGACCGCGCCATCACCGGCGACATGCTGGACCCGCGTCTGACCGGCGCGACCTTC
GTCGATCTCCCCGAATCGCTGCGTCAGTCGGGCATCACCGGGGTGATGGTGAGCGAGGTCAAACGCGGCGGTCGCGCTGC
CGCCAACGGCCTGGTCGCCGGCGATGTGATCGTGGCCAGCAGCGTGGGCGAGTTCGCCGACCTTGCCAGCTGGCGGGCCA
ATTTCCAACGTAAACCGCAGCAGCTTGTCGTGCGTATCCTGCGTGGCAACGCGCAGTACGACGCGCTGATGCGTTGA

Upstream 100 bases:

>100_bases
TTCACCGGCAGTTAAATTGCATGCGGGCACTCTCGTTCAGCTTGATTTACGTAGTCAGACGCCCTATTCCTCATCCACCG
CGTAACCCGGAATCCGTTCC

Downstream 100 bases:

>100_bases
CGCACTGTGTACCGAAAGTTGGTTGCACTAACGCCTCCTACACCCCCCCGGTGCTATTGCTACCGCTCGACCGCACGTGA
GTGGCGGCTGCCATCAATGA

Product: protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRPLPTLLTLSLAAAFGGFAATGINAWLDNRAEATPPSNAAFTLPTAAALPAAVAGQPVPSLAPMLQQAMPAVVSVNTKQ
VVRVRNPFFNDPILRRLFPQVPQDRINESLGSGVIIDAQKGYVLTNHHVIENADDVQVTLGDGRTVKAEFIGSDADTDIA
LIRIKADNLTDIKLADSNALRVGDFVVAIGNPFGFTQTVTSGIVSAVGRSGIRGLGYQNFIQTDASINPGNSGGALVNLQ
GQLVGINTASFNPQGSMAGNIGLGLAIPSNLARNVVEQLVTKGVVVRGTLGLETQNLTQQMLQGLGVDSLRGALVTRVLP
GSAAAAAGVQPGDVVVAANDQRVDSAEALHNYEGLQAVGSAVTLDIRRDGKPLKLKATLREQDRAITGDMLDPRLTGATF
VDLPESLRQSGITGVMVSEVKRGGRAAANGLVAGDVIVASSVGEFADLASWRANFQRKPQQLVVRILRGNAQYDALMR

Sequences:

>Translated_478_residues
MRPLPTLLTLSLAAAFGGFAATGINAWLDNRAEATPPSNAAFTLPTAAALPAAVAGQPVPSLAPMLQQAMPAVVSVNTKQ
VVRVRNPFFNDPILRRLFPQVPQDRINESLGSGVIIDAQKGYVLTNHHVIENADDVQVTLGDGRTVKAEFIGSDADTDIA
LIRIKADNLTDIKLADSNALRVGDFVVAIGNPFGFTQTVTSGIVSAVGRSGIRGLGYQNFIQTDASINPGNSGGALVNLQ
GQLVGINTASFNPQGSMAGNIGLGLAIPSNLARNVVEQLVTKGVVVRGTLGLETQNLTQQMLQGLGVDSLRGALVTRVLP
GSAAAAAGVQPGDVVVAANDQRVDSAEALHNYEGLQAVGSAVTLDIRRDGKPLKLKATLREQDRAITGDMLDPRLTGATF
VDLPESLRQSGITGVMVSEVKRGGRAAANGLVAGDVIVASSVGEFADLASWRANFQRKPQQLVVRILRGNAQYDALMR
>Mature_478_residues
MRPLPTLLTLSLAAAFGGFAATGINAWLDNRAEATPPSNAAFTLPTAAALPAAVAGQPVPSLAPMLQQAMPAVVSVNTKQ
VVRVRNPFFNDPILRRLFPQVPQDRINESLGSGVIIDAQKGYVLTNHHVIENADDVQVTLGDGRTVKAEFIGSDADTDIA
LIRIKADNLTDIKLADSNALRVGDFVVAIGNPFGFTQTVTSGIVSAVGRSGIRGLGYQNFIQTDASINPGNSGGALVNLQ
GQLVGINTASFNPQGSMAGNIGLGLAIPSNLARNVVEQLVTKGVVVRGTLGLETQNLTQQMLQGLGVDSLRGALVTRVLP
GSAAAAAGVQPGDVVVAANDQRVDSAEALHNYEGLQAVGSAVTLDIRRDGKPLKLKATLREQDRAITGDMLDPRLTGATF
VDLPESLRQSGITGVMVSEVKRGGRAAANGLVAGDVIVASSVGEFADLASWRANFQRKPQQLVVRILRGNAQYDALMR

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=301, Percent_Identity=34.8837209302326, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI7019477, Length=334, Percent_Identity=34.1317365269461, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI24308541, Length=251, Percent_Identity=34.2629482071713, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI22129776, Length=306, Percent_Identity=32.6797385620915, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1786356, Length=460, Percent_Identity=43.695652173913, Blast_Score=331, Evalue=8e-92,
Organism=Escherichia coli, GI1789629, Length=441, Percent_Identity=44.4444444444444, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=43.2142857142857, Blast_Score=207, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=35.4948805460751, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49966; Mature: 49966

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLPTLLTLSLAAAFGGFAATGINAWLDNRAEATPPSNAAFTLPTAAALPAAVAGQPVP
CCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHCCHHHCCCCCC
SLAPMLQQAMPAVVSVNTKQVVRVRNPFFNDPILRRLFPQVPQDRINESLGSGVIIDAQK
HHHHHHHHHCCCEEECCHHHHEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEECCC
GYVLTNHHVIENADDVQVTLGDGRTVKAEFIGSDADTDIALIRIKADNLTDIKLADSNAL
CEEEECCEEECCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCE
RVGDFVVAIGNPFGFTQTVTSGIVSAVGRSGIRGLGYQNFIQTDASINPGNSGGALVNLQ
EECEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCEEEEEC
GQLVGINTASFNPQGSMAGNIGLGLAIPSNLARNVVEQLVTKGVVVRGTLGLETQNLTQQ
CEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
MLQGLGVDSLRGALVTRVLPGSAAAAAGVQPGDVVVAANDQRVDSAEALHNYEGLQAVGS
HHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCC
AVTLDIRRDGKPLKLKATLREQDRAITGDMLDPRLTGATFVDLPESLRQSGITGVMVSEV
EEEEEEECCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHCCCCEEEHHHH
KRGGRAAANGLVAGDVIVASSVGEFADLASWRANFQRKPQQLVVRILRGNAQYDALMR
HCCCCHHHCCCEECCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MRPLPTLLTLSLAAAFGGFAATGINAWLDNRAEATPPSNAAFTLPTAAALPAAVAGQPVP
CCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHCCHHHCCCCCC
SLAPMLQQAMPAVVSVNTKQVVRVRNPFFNDPILRRLFPQVPQDRINESLGSGVIIDAQK
HHHHHHHHHCCCEEECCHHHHEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEECCC
GYVLTNHHVIENADDVQVTLGDGRTVKAEFIGSDADTDIALIRIKADNLTDIKLADSNAL
CEEEECCEEECCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCE
RVGDFVVAIGNPFGFTQTVTSGIVSAVGRSGIRGLGYQNFIQTDASINPGNSGGALVNLQ
EECEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCEEEEEC
GQLVGINTASFNPQGSMAGNIGLGLAIPSNLARNVVEQLVTKGVVVRGTLGLETQNLTQQ
CEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
MLQGLGVDSLRGALVTRVLPGSAAAAAGVQPGDVVVAANDQRVDSAEALHNYEGLQAVGS
HHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCC
AVTLDIRRDGKPLKLKATLREQDRAITGDMLDPRLTGATFVDLPESLRQSGITGVMVSEV
EEEEEEECCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHCCCCEEEHHHH
KRGGRAAANGLVAGDVIVASSVGEFADLASWRANFQRKPQQLVVRILRGNAQYDALMR
HCCCCHHHCCCEECCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]