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The map label for this gene is fabB [H]

Identifier: 21244350

GI number: 21244350

Start: 4298359

End: 4299567

Strand: Direct

Name: fabB [H]

Synonym: XAC3625

Alternate gene names: 21244350

Gene position: 4298359-4299567 (Clockwise)

Preceding gene: 21244349

Following gene: 77748734

Centisome position: 83.05

GC content: 66.0

Gene sequence:

>1209_bases
ATGCGTCGCGTCGTCATTACCGGAATGGGCATCACCTCATGCCTGGGCAACGATCTGGACACCGTCTCCAGCGCATTGCG
CGAGAGCCGCTCTGGCATCACCGCGCTGCCCGATCACGCCGAAGCAGGCCTGCGTAGCCAGGTCGGCGGTGCGGTGGCGC
TGGATCTGGACAGCCTGATCGACCGTAAGCTCAAACGCTTCATGGGCGATGCCTCGGCCTACGCGTACTTGGCAATGCGC
GACGCGATCGCCGATGCGGGCCTGGATGCCGAGCTGGTCAGCGGCCTGCGTACCGGCGTGATTGCCGGCTCCGGTGGCGG
CTCCAGCCAATGGCAGGTGGAAACCGCCGATCTGCTGCGCAACCGTGGCGTGCGCAAGGTGGGCCCATACATGGTGCCGC
GCACGATGTGTTCGTCAGTGTCCGCATCGCTAGCCACTGCGTTCAAAATACGCGGACTGAGCTACTCGCTGTCGGCCGCG
TGCGCGACGTCTGCGCATTGCATCGGTGCGGCGGCAGATCTGATCCGGCATGGCGCACAGGACGTGATGTTCGCCGGTGG
CGGCGAAGAACTGCACTGGACGATGAGCGTGATGTTCGATGCGATGGGCGCGCTGTCCACCGGTTCCAACGATCGCCCCG
CCGTGGCCTCGCGCCCGTACGATGCGCAGCGCGATGGCTTCGTCATCGGCAGCGGCGGCGGCATGCTGGTGCTGGAAGAC
TACGATCACGCCATCGCACGCGGCGCACGCATCCATGCCGAACTGCTCGGCTATGGCGTGACCTCCGACGGTGCCGACAT
GGTCGCGCCCAGCGGCGAAGGCGCCGTGCGCTGCATGCGAATGGCCATGCAGGGGCTGCAGCGTCCCATCGATTACCTCA
ACACGCATGGCACGTCCACGCCGCTGGGCGATGTCACCGAACTGGGCGCGGTGCGCGAGGTATTCGGCGACAACGTGCCG
CCGCTGTCTTCGACCAAGGGGCTCTCCGGGCACTCGCTGGGCGCGGCCAGCGTGCACGAGGCGATCTACAGCCTGCTGAT
GCTGCGCGATGGCTTCATGGCCGGCTCGGCGCATATCGACGACCTCGATCCGCGCGCCGAAGGCTTTCCCATCTTGCGGC
AGACGCAGGACGCGACCTTGAACACGGTGATGTCCAACAGTTTCGGCTTTGGTGGCACCAACGCGGCACTGGTCTTCGGG
CGAACCTAA

Upstream 100 bases:

>100_bases
TGATGGCGCAGACCGATGCACGCATGCTGGTGGATGGGCGCGAGATCTACACCGCCAAGGATCTGCGTGTGGGCATGTTC
ACTTCAACGGAGAATTTCTG

Downstream 100 bases:

>100_bases
ACCATCTACCCGCATCGGTGCCGTCCAAGCCGATGCAGGCATTCACACGATGTCGTCTGTCGCGCTGCAGCGCCTACGTA
AACCGCCGATCAAGAGTCCT

Product: beta-ketoacyl-[ACP] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MRRVVITGMGITSCLGNDLDTVSSALRESRSGITALPDHAEAGLRSQVGGAVALDLDSLIDRKLKRFMGDASAYAYLAMR
DAIADAGLDAELVSGLRTGVIAGSGGGSSQWQVETADLLRNRGVRKVGPYMVPRTMCSSVSASLATAFKIRGLSYSLSAA
CATSAHCIGAAADLIRHGAQDVMFAGGGEELHWTMSVMFDAMGALSTGSNDRPAVASRPYDAQRDGFVIGSGGGMLVLED
YDHAIARGARIHAELLGYGVTSDGADMVAPSGEGAVRCMRMAMQGLQRPIDYLNTHGTSTPLGDVTELGAVREVFGDNVP
PLSSTKGLSGHSLGAASVHEAIYSLLMLRDGFMAGSAHIDDLDPRAEGFPILRQTQDATLNTVMSNSFGFGGTNAALVFG
RT

Sequences:

>Translated_402_residues
MRRVVITGMGITSCLGNDLDTVSSALRESRSGITALPDHAEAGLRSQVGGAVALDLDSLIDRKLKRFMGDASAYAYLAMR
DAIADAGLDAELVSGLRTGVIAGSGGGSSQWQVETADLLRNRGVRKVGPYMVPRTMCSSVSASLATAFKIRGLSYSLSAA
CATSAHCIGAAADLIRHGAQDVMFAGGGEELHWTMSVMFDAMGALSTGSNDRPAVASRPYDAQRDGFVIGSGGGMLVLED
YDHAIARGARIHAELLGYGVTSDGADMVAPSGEGAVRCMRMAMQGLQRPIDYLNTHGTSTPLGDVTELGAVREVFGDNVP
PLSSTKGLSGHSLGAASVHEAIYSLLMLRDGFMAGSAHIDDLDPRAEGFPILRQTQDATLNTVMSNSFGFGGTNAALVFG
RT
>Mature_402_residues
MRRVVITGMGITSCLGNDLDTVSSALRESRSGITALPDHAEAGLRSQVGGAVALDLDSLIDRKLKRFMGDASAYAYLAMR
DAIADAGLDAELVSGLRTGVIAGSGGGSSQWQVETADLLRNRGVRKVGPYMVPRTMCSSVSASLATAFKIRGLSYSLSAA
CATSAHCIGAAADLIRHGAQDVMFAGGGEELHWTMSVMFDAMGALSTGSNDRPAVASRPYDAQRDGFVIGSGGGMLVLED
YDHAIARGARIHAELLGYGVTSDGADMVAPSGEGAVRCMRMAMQGLQRPIDYLNTHGTSTPLGDVTELGAVREVFGDNVP
PLSSTKGLSGHSLGAASVHEAIYSLLMLRDGFMAGSAHIDDLDPRAEGFPILRQTQDATLNTVMSNSFGFGGTNAALVFG
RT

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.7314148681055, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI223972627, Length=136, Percent_Identity=41.1764705882353, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=27.9761904761905, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788663, Length=401, Percent_Identity=62.8428927680798, Blast_Score=500, Evalue=1e-143,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=40, Blast_Score=248, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=36.0774818401937, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=40.0763358778626, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=24.6498599439776, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=24.5810055865922, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=32.9571106094808, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=37.1158392434988, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 41870; Mature: 41870

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGITSCLGNDLDTVSSALRESRSGITALPDHAEAGLRSQVGGAVALDLDSLI
CCEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHCHHHHCCCEEEECHHHHH
DRKLKRFMGDASAYAYLAMRDAIADAGLDAELVSGLRTGVIAGSGGGSSQWQVETADLLR
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEECCCCCCCEEEEHHHHHH
NRGVRKVGPYMVPRTMCSSVSASLATAFKIRGLSYSLSAACATSAHCIGAAADLIRHGAQ
HCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DVMFAGGGEELHWTMSVMFDAMGALSTGSNDRPAVASRPYDAQRDGFVIGSGGGMLVLED
CEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEC
YDHAIARGARIHAELLGYGVTSDGADMVAPSGEGAVRCMRMAMQGLQRPIDYLNTHGTST
CCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLGDVTELGAVREVFGDNVPPLSSTKGLSGHSLGAASVHEAIYSLLMLRDGFMAGSAHID
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
DLDPRAEGFPILRQTQDATLNTVMSNSFGFGGTNAALVFGRT
CCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRRVVITGMGITSCLGNDLDTVSSALRESRSGITALPDHAEAGLRSQVGGAVALDLDSLI
CCEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHCHHHHCCCEEEECHHHHH
DRKLKRFMGDASAYAYLAMRDAIADAGLDAELVSGLRTGVIAGSGGGSSQWQVETADLLR
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEECCCCCCCEEEEHHHHHH
NRGVRKVGPYMVPRTMCSSVSASLATAFKIRGLSYSLSAACATSAHCIGAAADLIRHGAQ
HCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DVMFAGGGEELHWTMSVMFDAMGALSTGSNDRPAVASRPYDAQRDGFVIGSGGGMLVLED
CEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEC
YDHAIARGARIHAELLGYGVTSDGADMVAPSGEGAVRCMRMAMQGLQRPIDYLNTHGTST
CCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLGDVTELGAVREVFGDNVPPLSSTKGLSGHSLGAASVHEAIYSLLMLRDGFMAGSAHID
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
DLDPRAEGFPILRQTQDATLNTVMSNSFGFGGTNAALVFGRT
CCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]