Click here to switch to the map view.

The map label for this gene is fabA

Identifier: 21244349

GI number: 21244349

Start: 4297844

End: 4298359

Strand: Direct

Name: fabA

Synonym: XAC3623

Alternate gene names: 21244349

Gene position: 4297844-4298359 (Clockwise)

Preceding gene: 21244343

Following gene: 21244350

Centisome position: 83.04

GC content: 62.02

Gene sequence:

>516_bases
ATGACTCGTCAAAGTACGTACTCGCGTGACCAATTGCTGGCCAGCGCGCGTGGGGAATTGTTTGCGCCCGACAGTGGCCG
TCTGCCCAATGATCCGATGCTGATGTTCGACCGCATTACCGAGATCAGCAACACCGGCGGCGCACATGGCAAGGGCGTGA
TTCGTGCCGAACTGGATATCCGCCCTGACCTATGGTTCTTCGGCTGCCACTTCATCGGCGACCCGGTGATGCCAGGCTGC
CTGGGCCTGGATGCGATGTGGCAGCTCACCGGCTTTTTCCTCACCTGGATCGGCGCGCCGGGCCGTGGCCGCGCATTGGG
CTGCGGCGAGGTCAAGTTCACCGGCCAGGTGCTGCCCAGCGCCAGGCTGGTGCGCTACGAGATCGATGTCAGCCGCGTCA
TCAACCGCAAGCTGGTGATGGCGCAGACCGATGCACGCATGCTGGTGGATGGGCGCGAGATCTACACCGCCAAGGATCTG
CGTGTGGGCATGTTCACTTCAACGGAGAATTTCTGA

Upstream 100 bases:

>100_bases
AACAGCACGCATGCGTACGGATAAAACGTTTGATTGAACCGCGCGACCTCATGCACCCTTCCCGGCCTCGCCTTTCGCTC
CTTTGCAGGAAACGTTCGTC

Downstream 100 bases:

>100_bases
TGCGTCGCGTCGTCATTACCGGAATGGGCATCACCTCATGCCTGGGCAACGATCTGGACACCGTCTCCAGCGCATTGCGC
GAGAGCCGCTCTGGCATCAC

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTRQSTYSRDQLLASARGELFAPDSGRLPNDPMLMFDRITEISNTGGAHGKGVIRAELDIRPDLWFFGCHFIGDPVMPGC
LGLDAMWQLTGFFLTWIGAPGRGRALGCGEVKFTGQVLPSARLVRYEIDVSRVINRKLVMAQTDARMLVDGREIYTAKDL
RVGMFTSTENF

Sequences:

>Translated_171_residues
MTRQSTYSRDQLLASARGELFAPDSGRLPNDPMLMFDRITEISNTGGAHGKGVIRAELDIRPDLWFFGCHFIGDPVMPGC
LGLDAMWQLTGFFLTWIGAPGRGRALGCGEVKFTGQVLPSARLVRYEIDVSRVINRKLVMAQTDARMLVDGREIYTAKDL
RVGMFTSTENF
>Mature_170_residues
TRQSTYSRDQLLASARGELFAPDSGRLPNDPMLMFDRITEISNTGGAHGKGVIRAELDIRPDLWFFGCHFIGDPVMPGCL
GLDAMWQLTGFFLTWIGAPGRGRALGCGEVKFTGQVLPSARLVRYEIDVSRVINRKLVMAQTDARMLVDGREIYTAKDLR
VGMFTSTENF

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=169, Percent_Identity=60.9467455621302, Blast_Score=227, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_XANAC (Q8PGJ2)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643931.1
- ProteinModelPortal:   Q8PGJ2
- SMR:   Q8PGJ2
- GeneID:   1157695
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3623
- NMPDR:   fig|190486.1.peg.3575
- HOGENOM:   HBG433282
- OMA:   CHFKGDP
- ProtClustDB:   PRK05174
- BioCyc:   XAXO190486:XAC3623-MONOMER
- BRENDA:   4.2.1.60
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114
- PANTHER:   PTHR11712
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 19021; Mature: 18890

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQSTYSRDQLLASARGELFAPDSGRLPNDPMLMFDRITEISNTGGAHGKGVIRAELDI
CCCCCCCCHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEC
RPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWIGAPGRGRALGCGEVKFTGQVLPS
CCCEEEEEHHHCCCCCCCCHHCHHHHHHHHHHHHHEECCCCCCCEEECCCEEEECEECCC
ARLVRYEIDVSRVINRKLVMAQTDARMLVDGREIYTAKDLRVGMFTSTENF
CEEEEEEECHHHHHCCEEEEEECCCEEEECCCEEEEECCCEEEEEECCCCC
>Mature Secondary Structure 
TRQSTYSRDQLLASARGELFAPDSGRLPNDPMLMFDRITEISNTGGAHGKGVIRAELDI
CCCCCCCHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEC
RPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWIGAPGRGRALGCGEVKFTGQVLPS
CCCEEEEEHHHCCCCCCCCHHCHHHHHHHHHHHHHEECCCCCCCEEECCCEEEECEECCC
ARLVRYEIDVSRVINRKLVMAQTDARMLVDGREIYTAKDLRVGMFTSTENF
CEEEEEEECHHHHHCCEEEEEECCCEEEECCCEEEEECCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217