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The map label for this gene is adk

Identifier: 21244162

GI number: 21244162

Start: 4047498

End: 4048061

Strand: Reverse

Name: adk

Synonym: XAC3437

Alternate gene names: 21244162

Gene position: 4048061-4047498 (Counterclockwise)

Preceding gene: 21244164

Following gene: 21244161

Centisome position: 78.22

GC content: 64.54

Gene sequence:

>564_bases
ATGCGATTGGTTCTGTTGGGACCGCCCGGTTCGGGCAAGGGCACCCAGGCGACACGTCTCAAAGACACGTTTGATATTCC
GCATATTTCCACCGGCGACCTGTTGCGCGCCGAAGTGGCCGCTGGCTCGCCGCTGGGATTGAAGGCCAAGGAAGTGATGG
CACGCGGCGACCTGGTGTCCGACGACATCCTGCTCGGCATGCTCGAGGCGCGCCTTGGCCAGGCCGATGTGGCCAAGGGT
TTCATCCTGGATGGCTACCCGCGCAACGTGGCCCAGGCCAATGCGCTGGACGAACTGCTCGGCAAGATCGGTCAGCCGCT
GGATGCCGTGGTGCAGCTGGATGTGGCCAGCGAGTTGCTGGTCGAGCGCATCGCCGGTCGTGCCAAGGCCGAAGGCCGCG
AAGACGACAACCCGGAATCGGTCCGCAAGCGTCTGCAGGTCTACACCGATTCAACTGCACCGGTGATCGGCTTCTACGAG
CAGCGCGGCAAGTTGGCGCGCGTGGATGGCGTGGGTTCGCTGGACGAAGTGCTGGAGCGCATCAGCAAGGCGCTCGGGCG
CTGA

Upstream 100 bases:

>100_bases
GGATGCGGTAAGCTGCACGGCCATACGGTCAGCGCCGGCGAAGACGTGAGTCTAACGCCGCCCACCGCAACGCGTTTTTA
TTCGAAAGTGGAGTCCACTG

Downstream 100 bases:

>100_bases
GTCGGTAGGGGACGCCCGGCGCAAGGCACGGTCTCGGCCATGCGCGGCCTCTGGTCGCGCTGCTTTCTCGCCGTGATCGC
CCGGACAACGTTACCCAAAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRLVLLGPPGSGKGTQATRLKDTFDIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKG
FILDGYPRNVAQANALDELLGKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYE
QRGKLARVDGVGSLDEVLERISKALGR

Sequences:

>Translated_187_residues
MRLVLLGPPGSGKGTQATRLKDTFDIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKG
FILDGYPRNVAQANALDELLGKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYE
QRGKLARVDGVGSLDEVLERISKALGR
>Mature_187_residues
MRLVLLGPPGSGKGTQATRLKDTFDIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKG
FILDGYPRNVAQANALDELLGKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYE
QRGKLARVDGVGSLDEVLERISKALGR

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=41.304347826087, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=38.785046728972, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=38.785046728972, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=34.2391304347826, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=34.2391304347826, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI7706497, Length=191, Percent_Identity=33.5078534031414, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=33.6633663366337, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=33.6633663366337, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=33.6633663366337, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=33.6633663366337, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI209915597, Length=187, Percent_Identity=28.8770053475936, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=33.8582677165354, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=41.2844036697248, Blast_Score=155, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=38.3177570093458, Blast_Score=149, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17567503, Length=178, Percent_Identity=40.4494382022472, Blast_Score=143, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=34.5945945945946, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=185, Percent_Identity=33.5135135135135, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=30.0925925925926, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25147457, Length=189, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=40.4651162790698, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=33.5106382978723, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=35.8585858585859, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=41.2322274881517, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=36.0406091370558, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=36.0406091370558, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24663208, Length=161, Percent_Identity=39.1304347826087, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17647141, Length=161, Percent_Identity=39.1304347826087, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI221459597, Length=187, Percent_Identity=34.2245989304813, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356893, Length=187, Percent_Identity=34.2245989304813, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24582962, Length=175, Percent_Identity=31.4285714285714, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_XANAC (Q8PH23)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643744.1
- ProteinModelPortal:   Q8PH23
- SMR:   Q8PH23
- GeneID:   1157508
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3437
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   XAXO190486:XAC3437-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19955; Mature: 19955

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGSGKGTQATRLKDTFDIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVS
CEEEEECCCCCCCCCCCHHCHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCH
DDILLGMLEARLGQADVAKGFILDGYPRNVAQANALDELLGKIGQPLDAVVQLDVASELL
HHHHHHHHHHHCCHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYEQRGKLARVDGVGSLDEVLER
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHCCCEEEECCCCCHHHHHHH
ISKALGR
HHHHHCC
>Mature Secondary Structure
MRLVLLGPPGSGKGTQATRLKDTFDIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVS
CEEEEECCCCCCCCCCCHHCHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCH
DDILLGMLEARLGQADVAKGFILDGYPRNVAQANALDELLGKIGQPLDAVVQLDVASELL
HHHHHHHHHHHCCHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYEQRGKLARVDGVGSLDEVLER
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHCCCEEEECCCCCHHHHHHH
ISKALGR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217