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The map label for this gene is ldp [H]

Identifier: 21242284

GI number: 21242284

Start: 1770580

End: 1772016

Strand: Reverse

Name: ldp [H]

Synonym: XAC1533

Alternate gene names: 21242284

Gene position: 1772016-1770580 (Counterclockwise)

Preceding gene: 21242285

Following gene: 21242283

Centisome position: 34.24

GC content: 65.69

Gene sequence:

>1437_bases
ATGAGCGAACAATTCGACGTCGTCGTCATCGGTGCCGGTCCGGCCGGTTATCACGCCGCCATCCGTGCGGCGCAGCTGGG
CATGAAGGTCGCCTGCATCGACGCGGCCCTGGGCAAGGACGGCAAGCCGGCACTGGGCGGTACCTGCCTGCGCGTGGGCT
GCATTCCGTCCAAGGCGCTGCTGGATTCCTCGCGCCAGTTCTGGAACATGGGCCACCTGTTCGGCGACCACGGAATCAGC
TTCAACGACGCCAAGATGGACGTGCCCACCATGATCGGCCGCAAGGACAAGATCGTGAAGCAGTTCACCGGCGGCATCGC
GATGCTGTTCAAGGCCAACAAGATCACCCCGTACTACGGCTTCGGCCAGTTGCAGCCGGGCAACATCGTCAAGGTGACCC
AGCATGAAGGCGGCGAGATCGAGCTCAAGGGCACCAACGTGATCCTGGCGGCCGGTTCGGAATCGATCGAACTGCCGTTC
GCCAAGTTCGACGGCGACACCATCGTCGACAACGTCGGCGGCCTGGATTTCACCGCCGTTCCCAAGCGTCTGGCCGTCAT
CGGTGCCGGCGTGATCGGCCTGGAGCTGGGCAGCGTGTGGAAGCGCCTGGGCGCCGAGGTGACCATCCTCGAAGCGCTGC
CGGACTTCCTGGCCCTGGCCGATGCCGAAGTGGCCAAGACCGCCTTGAAGGAATTCAAGAAGCAGGGTCTGGACATCAAG
CTGGGCGCCAAGGTCGGCAAGACCGAGATCACCGGCAGCGACGACGCCAAGCAGGTGGTGCTCAGCTACACCGACGCGAC
CGGCGAGCAGACCCTGACCGTGGACAAGCTGCTGGTGGCCGTGGGCCGCAAGGCCGCCACCAAGAACCTGCTGGCCGACG
GCACGGGCGTCAAGGTCACCGACCGCGGCCAGATCGAGGTCGACGGGCATTGCCACACCGGCGTGGATGGCGTGTGGGCG
ATCGGCGACTGCGTGCGCGGCCCGATGCTGGCGCACAAGGGCTTCGAGGAAGGCATCGCGGTGGCCGAATTGATCGCCGG
CCTGCCGGGTCACGTCAATTTCGACACCATTCCGTGGGTCATCTACACCGAGCCGGAAATCGCCTGGGTCGGCAAGACCG
AGCAGCAGCTCAAGGCCGAGGGCGTCGCCTACAAGGCCGGCAGCTTCCCGTTCGCAGCGATCGGTCGCGCGGTGGCGATG
GGCGAGCCGGCCGGCTTCGTCAAAGTGATCGCCGATGCCGAAACCGACCGCGTGCTGGGTATGCACCTGGTGGGCGTGGG
CGTTTCCGAGCTGGTGCACGAAGGCGTGCTGACCATGGAGTTCAGCGGCTCGGCCGACGACCTGGCCCGCATCTGCCACG
CGCACCCGACGCTGTCCGAAGCGATCCACGATGCCGCGATGGCGGTGAGCAAGCGCGCGATTCATAAGGCCAATTAA

Upstream 100 bases:

>100_bases
TGGACCGCTCCATTCCCGCCTGGACCTGGATGGGACGCCAAGGGCGCGTGCGCTATTGCGATTCCCCATTCCCTATTCCC
CATTCCCGTGAGCAAATGAA

Downstream 100 bases:

>100_bases
GTCGGGAATCGGGAGTGGGGAATCGGGAATCGTAGAAGCGCTCCCATCACTTCACTCTTCATGCTGACGCCGGACCCAGG
TCCGGCGTCATGCGTTCCGG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: E3 component of 2-oxoglutarate dehydrogenase complex; Glycine oxidation system L-factor; LPD-GLC [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHLFGDHGIS
FNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYGFGQLQPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPF
AKFDGDTIVDNVGGLDFTAVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLDIK
LGAKVGKTEITGSDDAKQVVLSYTDATGEQTLTVDKLLVAVGRKAATKNLLADGTGVKVTDRGQIEVDGHCHTGVDGVWA
IGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAM
GEPAGFVKVIADAETDRVLGMHLVGVGVSELVHEGVLTMEFSGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN

Sequences:

>Translated_478_residues
MSEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHLFGDHGIS
FNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYGFGQLQPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPF
AKFDGDTIVDNVGGLDFTAVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLDIK
LGAKVGKTEITGSDDAKQVVLSYTDATGEQTLTVDKLLVAVGRKAATKNLLADGTGVKVTDRGQIEVDGHCHTGVDGVWA
IGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAM
GEPAGFVKVIADAETDRVLGMHLVGVGVSELVHEGVLTMEFSGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN
>Mature_477_residues
SEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHLFGDHGISF
NDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYGFGQLQPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPFA
KFDGDTIVDNVGGLDFTAVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLDIKL
GAKVGKTEITGSDDAKQVVLSYTDATGEQTLTVDKLLVAVGRKAATKNLLADGTGVKVTDRGQIEVDGHCHTGVDGVWAI
GDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAMG
EPAGFVKVIADAETDRVLGMHLVGVGVSELVHEGVLTMEFSGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN

Specific function: Also acts in the glycine cleavage system [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=45.7446808510638, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=23.2905982905983, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=26.2605042016807, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI33519430, Length=477, Percent_Identity=22.4318658280922, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI33519428, Length=477, Percent_Identity=22.4318658280922, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI33519426, Length=477, Percent_Identity=22.4318658280922, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI148277065, Length=477, Percent_Identity=22.4318658280922, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI148277071, Length=477, Percent_Identity=22.4318658280922, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=22.1748400852878, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI291045268, Length=460, Percent_Identity=21.304347826087, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=40.4347826086956, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI87082354, Length=472, Percent_Identity=29.0254237288136, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=28.3261802575107, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789915, Length=470, Percent_Identity=25.9574468085106, Blast_Score=141, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=477, Percent_Identity=45.4926624737945, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17557007, Length=495, Percent_Identity=25.6565656565657, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=396, Percent_Identity=25.2525252525253, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71983419, Length=396, Percent_Identity=25.2525252525253, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=22.6337448559671, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=148, Percent_Identity=29.0540540540541, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=45.643153526971, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=27.2151898734177, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=22.8813559322034, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=47.3460721868365, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24640553, Length=491, Percent_Identity=26.2729124236253, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640549, Length=491, Percent_Identity=26.2729124236253, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640551, Length=491, Percent_Identity=26.2729124236253, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=24.2857142857143, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50210; Mature: 50079

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKAL
CCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCHHH
LDSSRQFWNMGHLFGDHGISFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYG
HHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCC
FGQLQPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPFAKFDGDTIVDNVGGLDFTAV
CCCCCCCCEEEEEECCCCEEEEECCEEEEEECCCCEECCEEECCCCEEECCCCCCCHHHH
PKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLDIK
HHHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LGAKVGKTEITGSDDAKQVVLSYTDATGEQTLTVDKLLVAVGRKAATKNLLADGTGVKVT
ECCCCCCEECCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHCCHHHHHHHHCCCCCEEEE
DRGQIEVDGHCHTGVDGVWAIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWV
CCCEEEECCCCCCCCCCEEEHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEE
IYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAMGEPAGFVKVIADAETDRVLG
EEECCCEEEECCCHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEE
MHLVGVGVSELVHEGVLTMEFSGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN
EEEECCCHHHHHHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKAL
CCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCHHH
LDSSRQFWNMGHLFGDHGISFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYG
HHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCC
FGQLQPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPFAKFDGDTIVDNVGGLDFTAV
CCCCCCCCEEEEEECCCCEEEEECCEEEEEECCCCEECCEEECCCCEEECCCCCCCHHHH
PKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLDIK
HHHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LGAKVGKTEITGSDDAKQVVLSYTDATGEQTLTVDKLLVAVGRKAATKNLLADGTGVKVT
ECCCCCCEECCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHCCHHHHHHHHCCCCCEEEE
DRGQIEVDGHCHTGVDGVWAIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWV
CCCEEEECCCCCCCCCCEEEHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEE
IYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAMGEPAGFVKVIADAETDRVLG
EEECCCEEEECCCHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEE
MHLVGVGVSELVHEGVLTMEFSGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN
EEEECCCHHHHHHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]