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The map label for this gene is parC [H]

Identifier: 21242194

GI number: 21242194

Start: 1662690

End: 1664933

Strand: Reverse

Name: parC [H]

Synonym: XAC1441

Alternate gene names: 21242194

Gene position: 1664933-1662690 (Counterclockwise)

Preceding gene: 21242195

Following gene: 21242193

Centisome position: 32.17

GC content: 64.97

Gene sequence:

>2244_bases
ATGACCGATCTGACCCGCCCCACCTTCCACGGCTTCGAACAACTACCGCTGCGCGAGTACGCAGAACGCGCCTATCTCGA
CTACTCGATGTACGTGGTGCTCGACCGCGCCCTGCCGTTCCTGGGCGACGGCCTGAAGCCGGTGCAGCGGCGCATCGTCT
ACGCAATGAGCGAGCTGGGCCTGAATGCCGCCGCCAAGCCGAAGAAATCCGCGCGTACCGTGGGCGATGTGATCGGTAAG
TACCACCCGCATGGCGACAGCGCCTGCTATGAAGCGCTGGTGCTGATGGCGCAGCCGTTCTCGTACCGTTACCCGCTGAT
CGAAGGCCAGGGCAACTTCGGCTCCACCGACGACCCCAAGTCGTTCGCAGCGATGCGCTATACCGAGTCCAAGCTGACCC
CGATCGCCGAAGTGCTGCTGGGCGAGCTTGGCCAGGGCACCACCGATTGGGCGCCCAACTTCGACGGCACCCTGGAAGAA
CCCACCTGGTTGCCGGCACGCCTGCCGCACCTGCTGCTCAACGGCACCACCGGCATTGCCGTGGGCATGGCCACCGACGT
GCCGCCGCACAATCTCAACGAGATCGTCAGTGCATTGCTGCGGCTGCTCGATGATCCCGATGCCAGCGTCGCCGACCTGT
GCGAGCACGTGCTGGGCCCGGATTACCCGACCACCGCCGAGATCATCACTCCGGCTGCGGACCTGCGGAACATCTACGAA
ACCGGTCACGGCAGCGTGCGCGCGCGCGCCACCTACAAGAAAGAGCACGCCAACATCTTCATCGATGCGCTGCCCTACCA
GGTCTCCCCGTCCAAGGTGATCGAGCAGATCGCCCAGCAGATGCGCGCCAAGAAGTTGCCGTGGCTGGAAGACATCCGCG
ACGAGTCCGACCACACCAGCCCGGTGCGGGTAGTGCTGGTGCCGCGCTCCAATCGCGTCGATGCCGAACAGCTGATGGGC
CACCTGTTCGTCACCACCGATCTGGAACGCAGCTACCGCGTCAACCTCAACGTGATCGGCCTGGATGGCCGCCCGCAGGT
CAAGAACCTCAAGCACCTGCTGAGCGAATGGCTGAGCTTCCGCAGCGATACGGTGACCCGCCGCCTCAACCATCGCCTGC
AGAAGGTCGAGCGTCGCCTGCACCTGTTGGAAGGCTTGTTGATCGCCTTCCTCAACCTGGACGAAGTGATCCGCATCGTC
CGCAGCGAAGACGAACCCAAGCCGGTGCTGATCTCGCGCTTCGCGCTGAGCGAAGAACAGGCCGAATACATCCTGGAAAC
CAAGCTGCGCCAACTGGCGCGCCTGGAAGAAATGAAGATCCGCGGCGAACAGGAAGCGCTCGCCGAGGAGCGCGCGCAGA
TCATGGCGATCCTGGAGAGCAAGACCAAGCTGAAGAAGCTGATCAAGGACGAACTGACTGCCGACGCCAAGAAGTTCGGC
GATGCGCGTCGTTCGCCGCTGGTGCAACGGGGCGCCGCACAGGCCATCGACGAAACCGAAATGGTGGCCAGCGAACCGAT
GACCGTGGTGCTGTCGCAAAAGGGCTGGGTCCGCGCGGCCAAGGGGCACGAGGTCGATCCGGCCGGCATGTCCTACCGCG
ATGGCGATGGCCTGCTGGCGGCGGTGCGCAGCCGCAGCACGCACCAGGTGGCGTTCCTGGATTCGGACGGCCGCGCCTAT
TCCACCGCCGTGCACACCCTGCCCTCGGCGCGTGGCAATGGCGAACCGTTGACCGGACGGTTCTCGCCGGCGTCTGGCGC
GGCGTTCCAGGTCATGGCCAGTGCCGACAACGCCACCCGCTTCGTGCTGGCGTCCTCGCATGGCTACGGCTTCGTTACCC
GTTTCGAAAACCTGACCGGCCGCAACAAGGCCGGCAAGGCGATGCTCAACCTGACCACCGGCTCGCATGTGCTGACGCCG
GCCCAGGTGAGCAACCCGCAAACCGATCGCATCGTCGCCGTGACCAGCGCCGGCAATCTGCTGGCGGTGCCGGCCACCGA
CGTGCCCGAGCTGGACAAGGGCAAAGGCAACAAGATCATCGAGATCCCCAAGGCCAAGCTCGGCACCGAACGTGTGGTGG
CCGTGGTGGCGGTCGCACCGGGCAACACCCTGCTGGTGCGCAGCGGCGCTCGTACCATGAGCCTGTCGTTCAAGGACCTG
GACACGTATGTGGGTGCGCGGGCGAGCCGTGGATCGTTGTTGCCGCGTGGGTGGCAAAAGGTGGACGGCCTGGAGGTGCA
GTAA

Upstream 100 bases:

>100_bases
CATGCACGCGGCTTGGCATCCCCCGCCGCATCCGGATAATCGGCGCTCTTCGAGCCCGTACCCCGGTGCGGGTTCCTCTT
CACGCAGGACCTGGCTTTAC

Downstream 100 bases:

>100_bases
CGGTTGTTCACCCATGCGGCGCGCGGCGGCGCGGCTGGGATTGCGGTCGCCTCAGGCTGCTGGGGCGCGGCAAAAGGTGG
ACGGCCTGGAGGTGCAGTAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELGLNAAAKPKKSARTVGDVIGK
YHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPKSFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEE
PTWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEIVSALLRLLDDPDASVADLCEHVLGPDYPTTAEIITPAADLRNIYE
TGHGSVRARATYKKEHANIFIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTSPVRVVLVPRSNRVDAEQLMG
HLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSFRSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIV
RSEDEPKPVLISRFALSEEQAEYILETKLRQLARLEEMKIRGEQEALAEERAQIMAILESKTKLKKLIKDELTADAKKFG
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSQKGWVRAAKGHEVDPAGMSYRDGDGLLAAVRSRSTHQVAFLDSDGRAY
STAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATRFVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTP
AQVSNPQTDRIVAVTSAGNLLAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
DTYVGARASRGSLLPRGWQKVDGLEVQ

Sequences:

>Translated_747_residues
MTDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELGLNAAAKPKKSARTVGDVIGK
YHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPKSFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEE
PTWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEIVSALLRLLDDPDASVADLCEHVLGPDYPTTAEIITPAADLRNIYE
TGHGSVRARATYKKEHANIFIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTSPVRVVLVPRSNRVDAEQLMG
HLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSFRSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIV
RSEDEPKPVLISRFALSEEQAEYILETKLRQLARLEEMKIRGEQEALAEERAQIMAILESKTKLKKLIKDELTADAKKFG
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSQKGWVRAAKGHEVDPAGMSYRDGDGLLAAVRSRSTHQVAFLDSDGRAY
STAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATRFVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTP
AQVSNPQTDRIVAVTSAGNLLAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
DTYVGARASRGSLLPRGWQKVDGLEVQ
>Mature_746_residues
TDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELGLNAAAKPKKSARTVGDVIGKY
HPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPKSFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEEP
TWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEIVSALLRLLDDPDASVADLCEHVLGPDYPTTAEIITPAADLRNIYET
GHGSVRARATYKKEHANIFIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTSPVRVVLVPRSNRVDAEQLMGH
LFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSFRSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIVR
SEDEPKPVLISRFALSEEQAEYILETKLRQLARLEEMKIRGEQEALAEERAQIMAILESKTKLKKLIKDELTADAKKFGD
ARRSPLVQRGAAQAIDETEMVASEPMTVVLSQKGWVRAAKGHEVDPAGMSYRDGDGLLAAVRSRSTHQVAFLDSDGRAYS
TAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATRFVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTPA
QVSNPQTDRIVAVTSAGNLLAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDLD
TYVGARASRGSLLPRGWQKVDGLEVQ

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=191, Percent_Identity=29.3193717277487, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI19913406, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=736, Percent_Identity=60.4619565217391, Blast_Score=932, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=752, Percent_Identity=33.9095744680851, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=511, Percent_Identity=24.6575342465753, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=29.8850574712644, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=381, Percent_Identity=23.3595800524934, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=196, Percent_Identity=28.0612244897959, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82209; Mature: 82078

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELG
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LNAAAKPKKSARTVGDVIGKYHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPK
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCH
SFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEEPTWLPARLPHLLLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCCEE
VGMATDVPPHNLNEIVSALLRLLDDPDASVADLCEHVLGPDYPTTAEIITPAADLRNIYE
EEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHH
TGHGSVRARATYKKEHANIFIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTS
CCCCCEEEEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCC
PVRVVLVPRSNRVDAEQLMGHLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSF
CEEEEEECCCCCCCHHHHHCEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIVRSEDEPKPVLISRFALSEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEHHHHCHHH
AEYILETKLRQLARLEEMKIRGEQEALAEERAQIMAILESKTKLKKLIKDELTADAKKFG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSQKGWVRAAKGHEVDPAGMSYRDGDGLLA
HHHCCHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCEECCCCHHH
AVRSRSTHQVAFLDSDGRAYSTAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATR
HHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
FVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTPAQVSNPQTDRIVAVTSAGNL
EEEECCCCCEEEEEHHCCCCCCCCCCEEEEEECCCEEECCHHCCCCCCCEEEEEECCCCE
LAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
EEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCEEEEECCCCEEEEEHHHH
DTYVGARASRGSLLPRGWQKVDGLEVQ
HHHHCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TDLTRPTFHGFEQLPLREYAERAYLDYSMYVVLDRALPFLGDGLKPVQRRIVYAMSELG
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LNAAAKPKKSARTVGDVIGKYHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSTDDPK
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCH
SFAAMRYTESKLTPIAEVLLGELGQGTTDWAPNFDGTLEEPTWLPARLPHLLLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCCCEE
VGMATDVPPHNLNEIVSALLRLLDDPDASVADLCEHVLGPDYPTTAEIITPAADLRNIYE
EEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHH
TGHGSVRARATYKKEHANIFIDALPYQVSPSKVIEQIAQQMRAKKLPWLEDIRDESDHTS
CCCCCEEEEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCC
PVRVVLVPRSNRVDAEQLMGHLFVTTDLERSYRVNLNVIGLDGRPQVKNLKHLLSEWLSF
CEEEEEECCCCCCCHHHHHCEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RSDTVTRRLNHRLQKVERRLHLLEGLLIAFLNLDEVIRIVRSEDEPKPVLISRFALSEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEHHHHCHHH
AEYILETKLRQLARLEEMKIRGEQEALAEERAQIMAILESKTKLKKLIKDELTADAKKFG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DARRSPLVQRGAAQAIDETEMVASEPMTVVLSQKGWVRAAKGHEVDPAGMSYRDGDGLLA
HHHCCHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCEECCCCHHH
AVRSRSTHQVAFLDSDGRAYSTAVHTLPSARGNGEPLTGRFSPASGAAFQVMASADNATR
HHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
FVLASSHGYGFVTRFENLTGRNKAGKAMLNLTTGSHVLTPAQVSNPQTDRIVAVTSAGNL
EEEECCCCCEEEEEHHCCCCCCCCCCEEEEEECCCEEECCHHCCCCCCCEEEEEECCCCE
LAVPATDVPELDKGKGNKIIEIPKAKLGTERVVAVVAVAPGNTLLVRSGARTMSLSFKDL
EEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCEEEEECCCCEEEEEHHHH
DTYVGARASRGSLLPRGWQKVDGLEVQ
HHHHCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]