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The map label for this gene is uppS [H]

Identifier: 21242170

GI number: 21242170

Start: 1632363

End: 1633136

Strand: Reverse

Name: uppS [H]

Synonym: XAC1417

Alternate gene names: 21242170

Gene position: 1633136-1632363 (Counterclockwise)

Preceding gene: 21242171

Following gene: 21242169

Centisome position: 31.55

GC content: 67.31

Gene sequence:

>774_bases
GTGGCGTCGCCTGCCATGCATCCAGTCCTCTCTGCTGCTGTGCCGCGCCACATCGCCATCATCATGGATGGCAATGGGCG
TTGGGCGCAGCGTCGGCGTCGTCCACGCGTCATCGGTCACCGTGCCGGCGCGCGCGCGGTCAATCGCACGATCGATTTCT
GCCTGGAAAAAGGCGTCTCGGCGCTGACCCTGTTCGCGTTCTCCAGTGAAAACTGGGGCCGTCCGCAGGATGAGGTCGAC
GCGCTGATGAAGCTGTTCCTGCATGCGCTCGACCGCGAGGTCGAAGAACTGCAGCGACGTGGCGTGCAGGTGCGCTTCAT
CGGCGACCGCAGCCGCTTTGCCGCACCCTTGCGCGACCGCATGGCCGGCGCCGAGCGCAGCACCGCAGCGAACTCGCGGC
TGGTGCTGAGCATCGCAGCCAGTTACGGCGGCCGCCAGGATATCGCCTCGGCTGCCCGCGCATTGGCCGAAGACGTCGCC
GCCGGCCGCCTGCAGCCAGAGCAGATCGACGAAGCGCTGCTGTCCAGCCGGGTCGCCCTGGCCGACCTGCCCGCGCCGGA
CCTGTTCATCCGCACCGGTGGCGACACCCGCATCAGCAACTTCCTGTTGTGGCAGCTGGCTTACACCGAGCTGTGGTTCA
CCGAAACCCTGTGGCCGGAGTTCGATGCCGGCGTGCTGCAGCAAGCGCTGGACGACTATGCCGGGCGTGAACGTCGCTTC
GGCCTGACCAGCGCACAGATCGCCGACAAGGCGACGGAGAGCTCCTCCGCATGA

Upstream 100 bases:

>100_bases
GCAGCGCCGAGGACGATATCCAGAAGCTCACCGACAAGGCCATCAAGGACGTGGATGAGGTCGTCAAAGGCAAGGAACAG
GAATTGATGACGGTCTGATC

Downstream 100 bases:

>100_bases
CCAAGACTCGCGTGATTGCCGCGCTGATCATGGCGCCGCTCGCGATTTGCGCGATCGTGCTGCTGCCCACCCAATGGCTG
GCAGCGCTGGCGGCGGTCCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MASPAMHPVLSAAVPRHIAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVD
ALMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRDRMAGAERSTAANSRLVLSIAASYGGRQDIASAARALAEDVA
AGRLQPEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDYAGRERRF
GLTSAQIADKATESSSA

Sequences:

>Translated_257_residues
MASPAMHPVLSAAVPRHIAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVD
ALMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRDRMAGAERSTAANSRLVLSIAASYGGRQDIASAARALAEDVA
AGRLQPEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDYAGRERRF
GLTSAQIADKATESSSA
>Mature_256_residues
ASPAMHPVLSAAVPRHIAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVDA
LMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRDRMAGAERSTAANSRLVLSIAASYGGRQDIASAARALAEDVAA
GRLQPEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDYAGRERRFG
LTSAQIADKATESSSA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=255, Percent_Identity=35.6862745098039, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI45580742, Length=248, Percent_Identity=35.4838709677419, Blast_Score=161, Evalue=6e-40,
Organism=Escherichia coli, GI1786371, Length=242, Percent_Identity=54.1322314049587, Blast_Score=269, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71993029, Length=247, Percent_Identity=32.3886639676113, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=36.1111111111111, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=32.4200913242009, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18857969, Length=256, Percent_Identity=34.765625, Blast_Score=140, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28373; Mature: 28242

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPAMHPVLSAAVPRHIAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLEKGVS
CCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ALTLFAFSSENWGRPQDEVDALMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRDR
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
MAGAERSTAANSRLVLSIAASYGGRQDIASAARALAEDVAAGRLQPEQIDEALLSSRVAL
HCCCCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
ADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDYAGRERRF
HCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHC
GLTSAQIADKATESSSA
CCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
ASPAMHPVLSAAVPRHIAIIMDGNGRWAQRRRRPRVIGHRAGARAVNRTIDFCLEKGVS
CCCHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ALTLFAFSSENWGRPQDEVDALMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRDR
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
MAGAERSTAANSRLVLSIAASYGGRQDIASAARALAEDVAAGRLQPEQIDEALLSSRVAL
HCCCCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
ADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDYAGRERRF
HCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHC
GLTSAQIADKATESSSA
CCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]