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The map label for this gene is bga [H]

Identifier: 21242061

GI number: 21242061

Start: 1505897

End: 1508461

Strand: Reverse

Name: bga [H]

Synonym: XAC1308

Alternate gene names: 21242061

Gene position: 1508461-1505897 (Counterclockwise)

Preceding gene: 21242062

Following gene: 21242056

Centisome position: 29.15

GC content: 65.96

Gene sequence:

>2565_bases
ATGAGCGGCATCAATCGGCGCGAGTTGCTGCGCGGCATGCTTGCCAGTGGGGTGAGCGCCGCACTGCCGGTGGGCGCAGC
CGGCACAGTGGCGTCGGCTGGCGCGACGGCTGCACCTGCAGCCAAGAACAGCGTCTCGACATCGGCACTAGGCGACGCAG
CGCTGGCACCGCGTGAGCGTCTGCTGTTCGACTTCGGTTGGCGCTTCCACCTGGGCCATGGCAGCGATGCGGCGCGCGAT
TTCGAATTCGGCACGTTCCAACGCACCTTCGCCAAGGCCGGCAAGGACACCGCGACCGCCGCGCAACTGGCGTTCGACGA
CAGTGCCTGGCAGCAGGTGGATCTGCCGCACGACTGGGCCGTCGGCCTGCCGTTTCGGCAGGAGCCCATCTCGGCCTCCA
TCACCGAGGAAGACCCGGCCGCTGCGCACGGCTACAAGCCGCTGGGCACGAGTTTCCCGGAGAACAGCGTGGGCTGGTAT
CGGCGCACGCTTCAGATTCCGGCCAGCGACCTGGGCAAGCGCATCAGCCTGGTGTTCGATGGCGTGTTTCGTGAGTGCAT
CGTGTTCTGCAATGGACACATCGTCGGCCGCAACGCGAGCGGCTACTGCGGCTTCGAAGTCGACCTCAGCGACGTGCTCG
ACTACGGCAAGCCCAACATCATCGCCATCCGCGTGGATGCCACGCTGGGCGAAGGCTGGTTCTACGAAGGCGCCGGCATC
TACCGGCACGTGTGGCTACAGAAGACCGACCCAGTCCATATCCCGCAAGACGGCGTGTTCGTGCGCAGCACCGTGCAGGA
TGGCAACGCCACTGCGCAGCTCTCCACCGAAGTGCGCAACGAGGGCAGCGCGCCGCGCCGATGCGTGGTGCAGGCGCGCA
TCACCGCACCGGATGGACGCACCGTGGCGCAAGCGTCCAGCGCAGTGGCCACCGTCGCGCCCGGCCAGGTGCAGGTGGTC
GAACAGACCTTGCCGCTCGGGCAGGCGGTGCTGTGGTCGATCGACGCCCCGCAGCTCTACCACCTGACTACCAGCGTGCA
TAGCGACGGCACTGCAGTCGATGCGCTGGTGACGCCGTTCGGCGTACGCAGCATCGCCTTCGATGCACAACGCGGTTTCC
TGTTGAACGGCGCACCGCTCAAGCTGCATGGCACCAACAATCACCAGGACCACGCGGGCGTCGGCACCGCCATTCCGGAC
GCCTTGCATGCATGGCGCCTGCGCCAGCTCAAGTCGATGGGCTGCAATGCCTACCGCAGTTCGCACAATCCGGCCACGCC
GGAATTACTCGCGCTGTGCGACCGCCTCGGCATGTTGGTGATCGAAGAAACCCGCCGCATGTCCACCGACCCGGAAGCGA
TGGGCGAACTGGAAACGATGGTGCGGCGTGGCCGCAATCATCCCAGCGTCATCCTGTGGTCGCTCGGCAACGAAGAGCCG
CAGCAAGTGACCGCGCGCGGTGCACGCATCGTGACCCGCATGCAACAACGCGTGCGCCAGCTGGATCCCACCCGCCCCAC
GACCTTCGCGATGGACAAAGGTTTTGGCGATGGCGTGGGCCAGGTGGTGGATGTGGTCGGCTTCAACTACCGCACCAGCC
AGATGGACGGCTTCCACGCGCAATACCCCAACATCCCGATCTACGGCAGCGAAACCGGCAGCACCGTGTCGGTGCGCGGC
AACTATCGGCGCGATGACCAACGCGGTTACACCCGCGCCTACGACCTGGACCACCCCTGGTGGGCCAGCACCGCCGAAGC
CTGGTGGAGCTATGTCGCGCAACGCCCCTACATTGCCGGCGGCTTCATCTGGACCGGCTTCGACTATCGCGGCGAGCCCA
CGCCCTACAACCGCTGGCCCAATGTGGCTTCGCAATTCGGCGTACTCGATAGCTGCGGTTTTCCGAAAGACAATTACTGG
TACTACCGCGCGCAATGGACCAGCGAACCGGTACTGCATCTGTTCCCGCACTGGAACTGGGACGGCTTGCTGGAGCCCGA
CGACAACGGCCGCATCGCGGTCTGGTGCCATAGCAATCTCGAGGCGGTGGAACTGCTGGTCAATGGCGTCAGCCAGGGCC
TGCAGCAGGTGCCGGCCTACGGCCATGTCGAATGGCGCGTGGTCTATGCGCCCGGCACGATCGAAGCGCGCGGCTATCGC
GGCGGCAAGCTGGTACTCAGCGAGCGTCGCGAAACCACAGGCAACCCGGCGGCGATTCGCTTGAGCTGCGATCGCAACAC
GCTGCGTGCCGATGCCGAAGATGTGGCCGTGGTGAAGGTGGAAATCCTCGATGCACAAGGCCGCCTGGTTCCGACCGCCG
ACAGCCTGGTGCAGTTCGCGCTACGCGGACCCGCACGGCTGATTGGGGTCGGCAATGGCGATCCCAGCAGCCACGAGGAC
GACAAGGCGCCGCGGCGCAAGGCGTTCAACGGCCTGTGTGCGGCACTGCTGCAAACCACGCGCAGCAGCGGCGAAATTGT
GCTGCAGGCCACCGCGCCTGGGCTGACCTCGTCCACGCTACGCCTGCCTGCCGAGCCCACGCGATCGCGCGCATCGGTGG
CTTGA

Upstream 100 bases:

>100_bases
ACCCGTATACCGGTGTGCCTGCAGCGATCAAAGCTGACGCGCGCAAGCGTCATGCGGACAGCCAGCACGTCCCTGCAGAG
GCCGAAAAAAGGACGCAGCC

Downstream 100 bases:

>100_bases
AACGCACGGCGACCGAACGTGCTGCGTTACCTGGGCCAGTGGTGGCCTCGGTAGCGTCGCGATGCCATAGGCGAGTCGAA
GGCCATCCATCGGTGTGTTT

Product: beta-galactosidase

Products: NA

Alternate protein names: Beta-gal; Lactase [H]

Number of amino acids: Translated: 854; Mature: 853

Protein sequence:

>854_residues
MSGINRRELLRGMLASGVSAALPVGAAGTVASAGATAAPAAKNSVSTSALGDAALAPRERLLFDFGWRFHLGHGSDAARD
FEFGTFQRTFAKAGKDTATAAQLAFDDSAWQQVDLPHDWAVGLPFRQEPISASITEEDPAAAHGYKPLGTSFPENSVGWY
RRTLQIPASDLGKRISLVFDGVFRECIVFCNGHIVGRNASGYCGFEVDLSDVLDYGKPNIIAIRVDATLGEGWFYEGAGI
YRHVWLQKTDPVHIPQDGVFVRSTVQDGNATAQLSTEVRNEGSAPRRCVVQARITAPDGRTVAQASSAVATVAPGQVQVV
EQTLPLGQAVLWSIDAPQLYHLTTSVHSDGTAVDALVTPFGVRSIAFDAQRGFLLNGAPLKLHGTNNHQDHAGVGTAIPD
ALHAWRLRQLKSMGCNAYRSSHNPATPELLALCDRLGMLVIEETRRMSTDPEAMGELETMVRRGRNHPSVILWSLGNEEP
QQVTARGARIVTRMQQRVRQLDPTRPTTFAMDKGFGDGVGQVVDVVGFNYRTSQMDGFHAQYPNIPIYGSETGSTVSVRG
NYRRDDQRGYTRAYDLDHPWWASTAEAWWSYVAQRPYIAGGFIWTGFDYRGEPTPYNRWPNVASQFGVLDSCGFPKDNYW
YYRAQWTSEPVLHLFPHWNWDGLLEPDDNGRIAVWCHSNLEAVELLVNGVSQGLQQVPAYGHVEWRVVYAPGTIEARGYR
GGKLVLSERRETTGNPAAIRLSCDRNTLRADAEDVAVVKVEILDAQGRLVPTADSLVQFALRGPARLIGVGNGDPSSHED
DKAPRRKAFNGLCAALLQTTRSSGEIVLQATAPGLTSSTLRLPAEPTRSRASVA

Sequences:

>Translated_854_residues
MSGINRRELLRGMLASGVSAALPVGAAGTVASAGATAAPAAKNSVSTSALGDAALAPRERLLFDFGWRFHLGHGSDAARD
FEFGTFQRTFAKAGKDTATAAQLAFDDSAWQQVDLPHDWAVGLPFRQEPISASITEEDPAAAHGYKPLGTSFPENSVGWY
RRTLQIPASDLGKRISLVFDGVFRECIVFCNGHIVGRNASGYCGFEVDLSDVLDYGKPNIIAIRVDATLGEGWFYEGAGI
YRHVWLQKTDPVHIPQDGVFVRSTVQDGNATAQLSTEVRNEGSAPRRCVVQARITAPDGRTVAQASSAVATVAPGQVQVV
EQTLPLGQAVLWSIDAPQLYHLTTSVHSDGTAVDALVTPFGVRSIAFDAQRGFLLNGAPLKLHGTNNHQDHAGVGTAIPD
ALHAWRLRQLKSMGCNAYRSSHNPATPELLALCDRLGMLVIEETRRMSTDPEAMGELETMVRRGRNHPSVILWSLGNEEP
QQVTARGARIVTRMQQRVRQLDPTRPTTFAMDKGFGDGVGQVVDVVGFNYRTSQMDGFHAQYPNIPIYGSETGSTVSVRG
NYRRDDQRGYTRAYDLDHPWWASTAEAWWSYVAQRPYIAGGFIWTGFDYRGEPTPYNRWPNVASQFGVLDSCGFPKDNYW
YYRAQWTSEPVLHLFPHWNWDGLLEPDDNGRIAVWCHSNLEAVELLVNGVSQGLQQVPAYGHVEWRVVYAPGTIEARGYR
GGKLVLSERRETTGNPAAIRLSCDRNTLRADAEDVAVVKVEILDAQGRLVPTADSLVQFALRGPARLIGVGNGDPSSHED
DKAPRRKAFNGLCAALLQTTRSSGEIVLQATAPGLTSSTLRLPAEPTRSRASVA
>Mature_853_residues
SGINRRELLRGMLASGVSAALPVGAAGTVASAGATAAPAAKNSVSTSALGDAALAPRERLLFDFGWRFHLGHGSDAARDF
EFGTFQRTFAKAGKDTATAAQLAFDDSAWQQVDLPHDWAVGLPFRQEPISASITEEDPAAAHGYKPLGTSFPENSVGWYR
RTLQIPASDLGKRISLVFDGVFRECIVFCNGHIVGRNASGYCGFEVDLSDVLDYGKPNIIAIRVDATLGEGWFYEGAGIY
RHVWLQKTDPVHIPQDGVFVRSTVQDGNATAQLSTEVRNEGSAPRRCVVQARITAPDGRTVAQASSAVATVAPGQVQVVE
QTLPLGQAVLWSIDAPQLYHLTTSVHSDGTAVDALVTPFGVRSIAFDAQRGFLLNGAPLKLHGTNNHQDHAGVGTAIPDA
LHAWRLRQLKSMGCNAYRSSHNPATPELLALCDRLGMLVIEETRRMSTDPEAMGELETMVRRGRNHPSVILWSLGNEEPQ
QVTARGARIVTRMQQRVRQLDPTRPTTFAMDKGFGDGVGQVVDVVGFNYRTSQMDGFHAQYPNIPIYGSETGSTVSVRGN
YRRDDQRGYTRAYDLDHPWWASTAEAWWSYVAQRPYIAGGFIWTGFDYRGEPTPYNRWPNVASQFGVLDSCGFPKDNYWY
YRAQWTSEPVLHLFPHWNWDGLLEPDDNGRIAVWCHSNLEAVELLVNGVSQGLQQVPAYGHVEWRVVYAPGTIEARGYRG
GKLVLSERRETTGNPAAIRLSCDRNTLRADAEDVAVVKVEILDAQGRLVPTADSLVQFALRGPARLIGVGNGDPSSHEDD
KAPRRKAFNGLCAALLQTTRSSGEIVLQATAPGLTSSTLRLPAEPTRSRASVA

Specific function: The Wild-Type Enzyme Is An Ineffective Lactase. Two Classes Of Point Mutations Dramatically Improve Activity Of The Enzyme. [C]

COG id: COG3250

COG function: function code G; Beta-galactosidase/beta-glucuronidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI268834192, Length=521, Percent_Identity=25.5278310940499, Blast_Score=134, Evalue=5e-31,
Organism=Escherichia coli, GI48994920, Length=418, Percent_Identity=28.9473684210526, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1786539, Length=537, Percent_Identity=27.3743016759777, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787903, Length=425, Percent_Identity=26.8235294117647, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17510825, Length=410, Percent_Identity=26.5853658536585, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI62471735, Length=426, Percent_Identity=28.4037558685446, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24655438, Length=426, Percent_Identity=28.4037558685446, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19922582, Length=426, Percent_Identity=28.4037558685446, Blast_Score=147, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24651745, Length=428, Percent_Identity=28.2710280373832, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003344
- InterPro:   IPR008979
- InterPro:   IPR006101
- InterPro:   IPR013812
- InterPro:   IPR006104
- InterPro:   IPR006102
- InterPro:   IPR006103
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00703 Glyco_hydro_2; PF02836 Glyco_hydro_2_C; PF02837 Glyco_hydro_2_N [H]

EC number: =3.2.1.23 [H]

Molecular weight: Translated: 93156; Mature: 93025

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGINRRELLRGMLASGVSAALPVGAAGTVASAGATAAPAAKNSVSTSALGDAALAPRER
CCCCCHHHHHHHHHHCCCHHHCCCCCCCCHHCCCCCCCCCCCCCCCHHHCCCHHCCCHHH
LLFDFGWRFHLGHGSDAARDFEFGTFQRTFAKAGKDTATAAQLAFDDSAWQQVDLPHDWA
HEEECCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHEEEECCCCCCCCCCCCCCE
VGLPFRQEPISASITEEDPAAAHGYKPLGTSFPENSVGWYRRTLQIPASDLGKRISLVFD
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHCCEEHHHHH
GVFRECIVFCNGHIVGRNASGYCGFEVDLSDVLDYGKPNIIAIRVDATLGEGWFYEGAGI
HHHHHHHHHCCCEEEECCCCCEEEEEEEHHHHHHCCCCCEEEEEEEEEECCCEEECCCCE
YRHVWLQKTDPVHIPQDGVFVRSTVQDGNATAQLSTEVRNEGSAPRRCVVQARITAPDGR
EEEEEEECCCCEECCCCCEEEEEEECCCCCEEEEEHHHHCCCCCCCEEEEEEEEECCCCC
TVAQASSAVATVAPGQVQVVEQTLPLGQAVLWSIDAPQLYHLTTSVHSDGTAVDALVTPF
CHHHHCCCEEEECCCCEEEEEHHCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHCCC
GVRSIAFDAQRGFLLNGAPLKLHGTNNHQDHAGVGTAIPDALHAWRLRQLKSMGCNAYRS
CHHHEEEECCCCEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
SHNPATPELLALCDRLGMLVIEETRRMSTDPEAMGELETMVRRGRNHPSVILWSLGNEEP
CCCCCCHHHHHHHHHHCCEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
QQVTARGARIVTRMQQRVRQLDPTRPTTFAMDKGFGDGVGQVVDVVGFNYRTSQMDGFHA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCEECCCCCCCCC
QYPNIPIYGSETGSTVSVRGNYRRDDQRGYTRAYDLDHPWWASTAEAWWSYVAQRPYIAG
CCCCCEEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCEEEC
GFIWTGFDYRGEPTPYNRWPNVASQFGVLDSCGFPKDNYWYYRAQWTSEPVLHLFPHWNW
CEEEECCCCCCCCCCCCCCCCHHHHCCCHHCCCCCCCCEEEEEEECCCCCEEEECCCCCC
DGLLEPDDNGRIAVWCHSNLEAVELLVNGVSQGLQQVPAYGHVEWRVVYAPGTIEARGYR
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCC
GGKLVLSERRETTGNPAAIRLSCDRNTLRADAEDVAVVKVEILDAQGRLVPTADSLVQFA
CCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCEECCHHHHHHHH
LRGPARLIGVGNGDPSSHEDDKAPRRKAFNGLCAALLQTTRSSGEIVLQATAPGLTSSTL
HCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEE
RLPAEPTRSRASVA
ECCCCCCCCCCCCC
>Mature Secondary Structure 
SGINRRELLRGMLASGVSAALPVGAAGTVASAGATAAPAAKNSVSTSALGDAALAPRER
CCCCHHHHHHHHHHCCCHHHCCCCCCCCHHCCCCCCCCCCCCCCCHHHCCCHHCCCHHH
LLFDFGWRFHLGHGSDAARDFEFGTFQRTFAKAGKDTATAAQLAFDDSAWQQVDLPHDWA
HEEECCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHEEEECCCCCCCCCCCCCCE
VGLPFRQEPISASITEEDPAAAHGYKPLGTSFPENSVGWYRRTLQIPASDLGKRISLVFD
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHCCEEHHHHH
GVFRECIVFCNGHIVGRNASGYCGFEVDLSDVLDYGKPNIIAIRVDATLGEGWFYEGAGI
HHHHHHHHHCCCEEEECCCCCEEEEEEEHHHHHHCCCCCEEEEEEEEEECCCEEECCCCE
YRHVWLQKTDPVHIPQDGVFVRSTVQDGNATAQLSTEVRNEGSAPRRCVVQARITAPDGR
EEEEEEECCCCEECCCCCEEEEEEECCCCCEEEEEHHHHCCCCCCCEEEEEEEEECCCCC
TVAQASSAVATVAPGQVQVVEQTLPLGQAVLWSIDAPQLYHLTTSVHSDGTAVDALVTPF
CHHHHCCCEEEECCCCEEEEEHHCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHCCC
GVRSIAFDAQRGFLLNGAPLKLHGTNNHQDHAGVGTAIPDALHAWRLRQLKSMGCNAYRS
CHHHEEEECCCCEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
SHNPATPELLALCDRLGMLVIEETRRMSTDPEAMGELETMVRRGRNHPSVILWSLGNEEP
CCCCCCHHHHHHHHHHCCEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
QQVTARGARIVTRMQQRVRQLDPTRPTTFAMDKGFGDGVGQVVDVVGFNYRTSQMDGFHA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCEECCCCCCCCC
QYPNIPIYGSETGSTVSVRGNYRRDDQRGYTRAYDLDHPWWASTAEAWWSYVAQRPYIAG
CCCCCEEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCEEEC
GFIWTGFDYRGEPTPYNRWPNVASQFGVLDSCGFPKDNYWYYRAQWTSEPVLHLFPHWNW
CEEEECCCCCCCCCCCCCCCCHHHHCCCHHCCCCCCCCEEEEEEECCCCCEEEECCCCCC
DGLLEPDDNGRIAVWCHSNLEAVELLVNGVSQGLQQVPAYGHVEWRVVYAPGTIEARGYR
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCC
GGKLVLSERRETTGNPAAIRLSCDRNTLRADAEDVAVVKVEILDAQGRLVPTADSLVQFA
CCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCEECCHHHHHHHH
LRGPARLIGVGNGDPSSHEDDKAPRRKAFNGLCAALLQTTRSSGEIVLQATAPGLTSSTL
HCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEE
RLPAEPTRSRASVA
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA