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The map label for this gene is obgE

Identifier: 21242004

GI number: 21242004

Start: 1426341

End: 1427408

Strand: Direct

Name: obgE

Synonym: XAC1250

Alternate gene names: 21242004

Gene position: 1426341-1427408 (Clockwise)

Preceding gene: 21242003

Following gene: 21242006

Centisome position: 27.56

GC content: 65.17

Gene sequence:

>1068_bases
ATGAAGCTAGTCGACGAAGCAGAAATCCTGGTCACCGCCGGTAATGGCGGCAATGGCTGTGTCGGCTTTCGCCGCGAGAA
GTTCATTCCGCTGGGCGGGCCCGATGGGGGCGATGGCGGTGCGGGCGGTAGTGTCTGGATCGTGGCCGACGAGAACGTCA
ACACACTGGTCGATTTCCGCCATGAGCGCACCTTCAAGGCGCAGCGCGGCGAGAACGGCATGGGGCGTCAGGCCTACGGC
AAGGGCGGCGAAGACCGCATCATCGTGGTGCCGGTCGGTACCGTGGTGATCAACGTGCAGACCGATGAAGTGATCGGCGA
CCTGACCCAGCACGGCGACCGCTTGCTGGTGGCCAAGGGCGGCAAGGGCGGCCTGGGCAACATGCATTTCAAGAGCTCGG
TCAACCGCGCGCCGCGCCAGGCGACCACCGGTGAGGAGGGCGAAGAGCGTCTGCTCAAGCTGGAACTGAAGCTGCTGGCC
GATGTCGGCCTGCTGGGTTTCCCCAATGCCGGCAAGAGCACCCTGATCCGTGCGGTGTCCGCGGCAACCCCGAAGGTGGC
CGACTACCCGTTCACGACCCTGTATCCGAATCTGGGCGTGGTCAGTGTCGAGGCGTACCGCAGTTTCGTCATCGCCGACG
TGCCGGGCCTGATCGAAGGCGCGGCCGACGGCGCCGGGCTGGGCACGCAGTTCCTGCGCCATTTGCAACGCACCCGCCTG
CTGCTGCATCTGGTGGATATTTCGCCTGCTCTGGGCGTGTATGGCGAGGGCGGTGTGGACGGCGTATCGCCGGCCGATCA
GGTGCGCACCATCGAGCGCGAGCTGGAACGGCACGATCCCGAGTTGCTGAAGAAGCCGCGCTGGCTGGTGCTCAACAAGG
CCGACCTGATGTTCGAAGACGAGGCGCGTGCCGCTGCAGAAACCATCGTGGCCGAGTTGGGCTGGACGGCGCCGTGGTAC
CTGGTTTCCGCTCTCGGGCGCGATGGCACCTTCCCGATCATGAAAGACGTGATGGCATTCTTCGATCGCCAGCGCGAAGA
CGAGCTCGAAGCGCGCAATGCGGGCTGA

Upstream 100 bases:

>100_bases
TTTTCTACAGCCGTGCTGGCGGGTGTTTTCGCCGGCAGGAATCCGCCGCTTTTGCTGGCCGATTCCCTATTCCCTATTCT
CAATTCCCGGTTGTCATCCC

Downstream 100 bases:

>100_bases
GTGCAGGCGCAGGCACACAAAAAACCCGGCCAAGGCCGGGTTTTTCTGTATTGCCGGAAGCCAGGCTGCCGGCAATGCGC
CAACTGGTCGCTTACGCGGC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKLVDEAEILVTAGNGGNGCVGFRREKFIPLGGPDGGDGGAGGSVWIVADENVNTLVDFRHERTFKAQRGENGMGRQAYG
KGGEDRIIVVPVGTVVINVQTDEVIGDLTQHGDRLLVAKGGKGGLGNMHFKSSVNRAPRQATTGEEGEERLLKLELKLLA
DVGLLGFPNAGKSTLIRAVSAATPKVADYPFTTLYPNLGVVSVEAYRSFVIADVPGLIEGAADGAGLGTQFLRHLQRTRL
LLHLVDISPALGVYGEGGVDGVSPADQVRTIERELERHDPELLKKPRWLVLNKADLMFEDEARAAAETIVAELGWTAPWY
LVSALGRDGTFPIMKDVMAFFDRQREDELEARNAG

Sequences:

>Translated_355_residues
MKLVDEAEILVTAGNGGNGCVGFRREKFIPLGGPDGGDGGAGGSVWIVADENVNTLVDFRHERTFKAQRGENGMGRQAYG
KGGEDRIIVVPVGTVVINVQTDEVIGDLTQHGDRLLVAKGGKGGLGNMHFKSSVNRAPRQATTGEEGEERLLKLELKLLA
DVGLLGFPNAGKSTLIRAVSAATPKVADYPFTTLYPNLGVVSVEAYRSFVIADVPGLIEGAADGAGLGTQFLRHLQRTRL
LLHLVDISPALGVYGEGGVDGVSPADQVRTIERELERHDPELLKKPRWLVLNKADLMFEDEARAAAETIVAELGWTAPWY
LVSALGRDGTFPIMKDVMAFFDRQREDELEARNAG
>Mature_355_residues
MKLVDEAEILVTAGNGGNGCVGFRREKFIPLGGPDGGDGGAGGSVWIVADENVNTLVDFRHERTFKAQRGENGMGRQAYG
KGGEDRIIVVPVGTVVINVQTDEVIGDLTQHGDRLLVAKGGKGGLGNMHFKSSVNRAPRQATTGEEGEERLLKLELKLLA
DVGLLGFPNAGKSTLIRAVSAATPKVADYPFTTLYPNLGVVSVEAYRSFVIADVPGLIEGAADGAGLGTQFLRHLQRTRL
LLHLVDISPALGVYGEGGVDGVSPADQVRTIERELERHDPELLKKPRWLVLNKADLMFEDEARAAAETIVAELGWTAPWY
LVSALGRDGTFPIMKDVMAFFDRQREDELEARNAG

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=347, Percent_Identity=39.7694524495677, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI111955139, Length=274, Percent_Identity=40.1459854014599, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI111955063, Length=130, Percent_Identity=44.6153846153846, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1789574, Length=341, Percent_Identity=60.7038123167155, Blast_Score=373, Evalue=1e-105,
Organism=Escherichia coli, GI1787454, Length=149, Percent_Identity=32.2147651006711, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508313, Length=342, Percent_Identity=37.719298245614, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=30.0970873786408, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=156, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=124, Percent_Identity=44.3548387096774, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=137, Percent_Identity=31.3868613138686, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585318, Length=314, Percent_Identity=37.8980891719745, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI20129375, Length=293, Percent_Identity=39.5904436860068, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_XANAC (Q8PN23)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641586.1
- HSSP:   P20964
- ProteinModelPortal:   Q8PN23
- SMR:   Q8PN23
- GeneID:   1155321
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1250
- NMPDR:   fig|190486.1.peg.1230
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12299
- BioCyc:   XAXO190486:XAC1250-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 38182; Mature: 38182

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVDEAEILVTAGNGGNGCVGFRREKFIPLGGPDGGDGGAGGSVWIVADENVNTLVDFR
CCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHH
HERTFKAQRGENGMGRQAYGKGGEDRIIVVPVGTVVINVQTDEVIGDLTQHGDRLLVAKG
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECEEEEEEEHHHHHHHHHHCCCEEEEEEC
GKGGLGNMHFKSSVNRAPRQATTGEEGEERLLKLELKLLADVGLLGFPNAGKSTLIRAVS
CCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AATPKVADYPFTTLYPNLGVVSVEAYRSFVIADVPGLIEGAADGAGLGTQFLRHLQRTRL
HCCCCCCCCCCHHHCCCCCEEEHHHHHHEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHLVDISPALGVYGEGGVDGVSPADQVRTIERELERHDPELLKKPRWLVLNKADLMFED
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCEEEEECCCCEECC
EARAAAETIVAELGWTAPWYLVSALGRDGTFPIMKDVMAFFDRQREDELEARNAG
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure
MKLVDEAEILVTAGNGGNGCVGFRREKFIPLGGPDGGDGGAGGSVWIVADENVNTLVDFR
CCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHH
HERTFKAQRGENGMGRQAYGKGGEDRIIVVPVGTVVINVQTDEVIGDLTQHGDRLLVAKG
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECEEEEEEEHHHHHHHHHHCCCEEEEEEC
GKGGLGNMHFKSSVNRAPRQATTGEEGEERLLKLELKLLADVGLLGFPNAGKSTLIRAVS
CCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AATPKVADYPFTTLYPNLGVVSVEAYRSFVIADVPGLIEGAADGAGLGTQFLRHLQRTRL
HCCCCCCCCCCHHHCCCCCEEEHHHHHHEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHLVDISPALGVYGEGGVDGVSPADQVRTIERELERHDPELLKKPRWLVLNKADLMFED
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCEEEEECCCCEECC
EARAAAETIVAELGWTAPWYLVSALGRDGTFPIMKDVMAFFDRQREDELEARNAG
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217