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The map label for this gene is dnaX [H]

Identifier: 21241864

GI number: 21241864

Start: 1259809

End: 1261878

Strand: Direct

Name: dnaX [H]

Synonym: XAC1109

Alternate gene names: 21241864

Gene position: 1259809-1261878 (Clockwise)

Preceding gene: 21241860

Following gene: 21241865

Centisome position: 24.34

GC content: 67.44

Gene sequence:

>2070_bases
ATGTCTTATCTTGTTCTCGCCCGCAAGTGGCGCCCGAAGCGTTTTGCCGAACTCGTAGGCCAGGAACACGTGGTCCGCGC
GCTCAGTAACGCGCTCGACAGTGGGCGCGTGCATCACGCGTTCCTGTTCACCGGCACCCGTGGCGTGGGCAAGACCACCA
TCGCGCGCATTTTCGCCAAATCGCTCAATTGCGAGACCGGCACCAGTGCCGATCCGTGCGGGACGTGCCCGGCCTGCCTG
GACATCGATGCCGGTCGCTACATCGACCTGCTGGAGATCGACGCCGCGTCCAACACCGGCGTGGACGACGTGCGCGAGGT
GATCGAGAACGCCCAGTACATGCCCTCGCGCGGAAAGTTCAAGGTCTACCTGATCGACGAAGTGCACATGCTCTCCAAGG
CGGCGTTCAATGCGCTGCTGAAGACGCTGGAAGAGCCGCCGGAACACGTGAAGTTCCTGCTGGCCACCACCGATCCGCAG
AAACTTCCGGTGACGGTGCTGTCGCGCTGCCTGCAGTTCAACCTCAAGCGGTTGGACGAAGACCAGATTCAGGGCCAGAT
GACACGCATCCTGGCCGCCGAACCGATCGAATCGGATCCGTCGGCGATCGTGCAGCTGTCCAAGGCGGCCGACGGTTCGC
TGCGCGATGGTCTGTCGCTGCTGGACCAGGCGATCGCCTATGCCGGCGGCGCGCTGCGCGAGGACGTGGTGCGCACCATG
CTGGGCACGGTCGATCGCACCCAGGTCGGCGCCATGCTGCACGCGTTGACCGACGGCGATGGCGCGCGCCTGCTGCAGGT
AGTGGCGGCGCTGGCCGAATTTTCGCCCGACTGGAGCGGCGTGCTGGAGGCCCTGGCCGAGGCGTTGCATCGAGTGCAGG
TGCAGCAGCTGGTGCCCTCGGTGGCCTTTGTCGGCGACGGCATCGACCCAACCCCGTTTGCAGCGCAGCTGCGGCCGGAA
GTGGTGCAGTTGTGGTACCAGATGGCGCTGAACGGGCGCCGCGATCTGTATCTGGCGCCCAGCCCGCGCGCCGGTTTCGA
AATGGCGGTGCTGCGCATGCTCGCCTTTCGCCCCGCAGCGGCGGTACCGGCTGGCGGCTCGGATGACGGGCGCGGTGCCA
CTGCTGGCGGTGGCGCGCGTTCGGCCGCTGCCGGCGGTCAGCTTGCTGCTCCAGTAGCGGCGGCACCGGTGACGTCCGCG
CCCGCCGTAGTGGCCGCGCCGACTGCGGTGACGGATACGATGCCTGTTGCGGCTGCGGAGGCGTCCTTGCCGGCATCAGG
GACCCGGGCAACTCCGGCTCCCCTTGTCGTGCTTTCTCCCCAAGAGTCTTCTCCGGCCAGTCGCGCGTCTGCAGCCAATG
CGCGCAATGACGACACGCCGCCCTGGGCAGTGGACGATGCGCCGGTGCGTGCGCGGGCCACGCCTACACCCGACACGATG
GGCGTGCTTGCGCCTGAAGCGGCAATGGCTCCGCCGTCTGCACCCGTCGAGCTCGCGCAACCCGATGGGATTGCGTCTGA
CGCTGCGGTGGAAGCTCCGGCTTCGGTTGTAGTGCCTTCACCGGCCGCGCTTGTCGAGCCCTCGTCGCCTGAAGAGCCAG
CGGTGGTCGCGTCAGCGGCAACGGCAGGGGCTGCATCAGACGCGGCAACCGACGCGGCGGCCCTGCTCGATGACGGCCGC
ATCGCCGATGCCGAGCAATGGCTGGAGCTGGTGACGCGCAGTGGCTTGAATGGCCCGTCGCGCCAGCTGGCCGCCAACGC
CGCGTTTATCGGCCATCGCGATGGCGTGCTGCGGCTCGCACTCGCGCCGGGCTTCGAATATCTCAACTCCGAGCGCTCCA
TCGCCAATCTCGCGCAGGCGCTGGCACCGGTGTTGGGAAACGCGCCGCGCATCGTCGTCGAAACCGGCAGCGCCGACGTC
GAAACCTTGCATGAGCGTGCCAGCCGCCAGAAAGGCGAGCGCCAGAGCGCGGCCGAAACAGCCTTCATGAACGACCCGAC
GGTGCAGCTGCTGGTTCAGCAGCAAGGCGCGCGGATCGTGCCCGATTCCATCCGCCCTTACGACGAGTAA

Upstream 100 bases:

>100_bases
TTCTAGCGGTCGCCGGCCCGTACCACAAGCTGAATCTTCCAGCCGCAGTCGTGGAGACCGGGCGTGGCACAATATCGGCT
CAAACAAAGCCGGTTGCCCG

Downstream 100 bases:

>100_bases
CGACCCATGCGTGGAAACATTGCCCAACTGATGCAGCAGGCGCAGAAGATGCAGGAAAACCTGCAGCGCGCCCAGGAAGA
ACTGGCCAAGCTGGAAGTCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MSYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAKSLNCETGTSADPCGTCPACL
DIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQ
KLPVTVLSRCLQFNLKRLDEDQIQGQMTRILAAEPIESDPSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
LGTVDRTQVGAMLHALTDGDGARLLQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPSVAFVGDGIDPTPFAAQLRPE
VVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAAAVPAGGSDDGRGATAGGGARSAAAGGQLAAPVAAAPVTSA
PAVVAAPTAVTDTMPVAAAEASLPASGTRATPAPLVVLSPQESSPASRASAANARNDDTPPWAVDDAPVRARATPTPDTM
GVLAPEAAMAPPSAPVELAQPDGIASDAAVEAPASVVVPSPAALVEPSSPEEPAVVASAATAGAASDAATDAAALLDDGR
IADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLALAPGFEYLNSERSIANLAQALAPVLGNAPRIVVETGSADV
ETLHERASRQKGERQSAAETAFMNDPTVQLLVQQQGARIVPDSIRPYDE

Sequences:

>Translated_689_residues
MSYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAKSLNCETGTSADPCGTCPACL
DIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQ
KLPVTVLSRCLQFNLKRLDEDQIQGQMTRILAAEPIESDPSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
LGTVDRTQVGAMLHALTDGDGARLLQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPSVAFVGDGIDPTPFAAQLRPE
VVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAAAVPAGGSDDGRGATAGGGARSAAAGGQLAAPVAAAPVTSA
PAVVAAPTAVTDTMPVAAAEASLPASGTRATPAPLVVLSPQESSPASRASAANARNDDTPPWAVDDAPVRARATPTPDTM
GVLAPEAAMAPPSAPVELAQPDGIASDAAVEAPASVVVPSPAALVEPSSPEEPAVVASAATAGAASDAATDAAALLDDGR
IADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLALAPGFEYLNSERSIANLAQALAPVLGNAPRIVVETGSADV
ETLHERASRQKGERQSAAETAFMNDPTVQLLVQQQGARIVPDSIRPYDE
>Mature_688_residues
SYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAKSLNCETGTSADPCGTCPACLD
IDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQK
LPVTVLSRCLQFNLKRLDEDQIQGQMTRILAAEPIESDPSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTML
GTVDRTQVGAMLHALTDGDGARLLQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPSVAFVGDGIDPTPFAAQLRPEV
VQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAAAVPAGGSDDGRGATAGGGARSAAAGGQLAAPVAAAPVTSAP
AVVAAPTAVTDTMPVAAAEASLPASGTRATPAPLVVLSPQESSPASRASAANARNDDTPPWAVDDAPVRARATPTPDTMG
VLAPEAAMAPPSAPVELAQPDGIASDAAVEAPASVVVPSPAALVEPSSPEEPAVVASAATAGAASDAATDAAALLDDGRI
ADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLALAPGFEYLNSERSIANLAQALAPVLGNAPRIVVETGSADVE
TLHERASRQKGERQSAAETAFMNDPTVQLLVQQQGARIVPDSIRPYDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=298, Percent_Identity=26.1744966442953, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI31881687, Length=298, Percent_Identity=26.1744966442953, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1786676, Length=370, Percent_Identity=54.0540540540541, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1787341, Length=241, Percent_Identity=30.7053941908714, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787119, Length=278, Percent_Identity=25.5395683453237, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=247, Percent_Identity=24.6963562753036, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=259, Percent_Identity=24.7104247104247, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=228, Percent_Identity=26.7543859649123, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324478, Length=227, Percent_Identity=24.6696035242291, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859927, Length=295, Percent_Identity=24.0677966101695, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647857, Length=281, Percent_Identity=24.5551601423488, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 71901; Mature: 71770

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAK
CCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHH
SLNCETGTSADPCGTCPACLDIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKF
HCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKRLDE
EEEEECHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
DQIQGQMTRILAAEPIESDPSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
HHHHHHHHHHHHCCCCCCCHHHHHEEHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGTVDRTQVGAMLHALTDGDGARLLQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPS
HCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VAFVGDGIDPTPFAAQLRPEVVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAA
HHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCC
AVPAGGSDDGRGATAGGGARSAAAGGQLAAPVAAAPVTSAPAVVAAPTAVTDTMPVAAAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCHHCCCCCCHHHH
ASLPASGTRATPAPLVVLSPQESSPASRASAANARNDDTPPWAVDDAPVRARATPTPDTM
CCCCCCCCCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GVLAPEAAMAPPSAPVELAQPDGIASDAAVEAPASVVVPSPAALVEPSSPEEPAVVASAA
CCCCCHHHCCCCCCCCCCCCCCCCCCCCHHCCCCEEECCCCHHEECCCCCCCCCEEEEHH
TAGAASDAATDAAALLDDGRIADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLA
HCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCEEEEE
LAPGFEYLNSERSIANLAQALAPVLGNAPRIVVETGSADVETLHERASRQKGERQSAAET
ECCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHHH
AFMNDPTVQLLVQQQGARIVPDSIRPYDE
HHCCCCHHHHEEECCCCEECCCCCCCCCC
>Mature Secondary Structure 
SYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAK
CEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHH
SLNCETGTSADPCGTCPACLDIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKF
HCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKRLDE
EEEEECHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
DQIQGQMTRILAAEPIESDPSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
HHHHHHHHHHHHCCCCCCCHHHHHEEHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGTVDRTQVGAMLHALTDGDGARLLQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPS
HCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VAFVGDGIDPTPFAAQLRPEVVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAA
HHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCC
AVPAGGSDDGRGATAGGGARSAAAGGQLAAPVAAAPVTSAPAVVAAPTAVTDTMPVAAAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCHHCCCCCCHHHH
ASLPASGTRATPAPLVVLSPQESSPASRASAANARNDDTPPWAVDDAPVRARATPTPDTM
CCCCCCCCCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GVLAPEAAMAPPSAPVELAQPDGIASDAAVEAPASVVVPSPAALVEPSSPEEPAVVASAA
CCCCCHHHCCCCCCCCCCCCCCCCCCCCHHCCCCEEECCCCHHEECCCCCCCCCEEEEHH
TAGAASDAATDAAALLDDGRIADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLA
HCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCEEEEE
LAPGFEYLNSERSIANLAQALAPVLGNAPRIVVETGSADVETLHERASRQKGERQSAAET
ECCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHHH
AFMNDPTVQLLVQQQGARIVPDSIRPYDE
HHCCCCHHHHEEECCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]