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The map label for this gene is ftsI [H]

Identifier: 21241544

GI number: 21241544

Start: 916562

End: 918430

Strand: Direct

Name: ftsI [H]

Synonym: XAC0774

Alternate gene names: 21241544

Gene position: 916562-918430 (Clockwise)

Preceding gene: 21241543

Following gene: 21241545

Centisome position: 17.71

GC content: 66.88

Gene sequence:

>1869_bases
ATGAAGGCTGGCCGCAACCGCCCCCGCAGCAATTTCAATCTCCGTGGTCGCCTGACCCTGGTCGGCATCGCGCTGGGCCT
GTGCTCGGTGACGCTGATCGGGCGCGCGGCCTACGTGCAGCTGGTCAACCGCGATTTTTACCAGCGTCAGGGCGAAGCGC
GTTACCTGCGCGAACTGCCCATCGCCACCTCGCGCGGCATGATCACCGACCGCAACGGCGAGCCGCTGGCGGTGTCCACG
CCGGTGGAGTCGATCTGGGTCAATCCGCAGGAACTGCTGCGTAACCCGGACCGCATTCCCGAGCTGGCAAAAGCGCTGGG
GCAGCCGCTGGACGATTTGAACGCCAAGCTGGCACAGAAGGCCGGCAAGGAATTCATGTACCTGCAGCGCCGGATCAATC
CGGACAAGGCGCATGCGATCGTCGATCTGAAGATTCCGGGCGTGTTCTCGCAGCGCGAGTTCCGTCGCTTCTATCCGCAA
GGCGAGGCGATGGCCCACGTGCTGGGCTTCACCAATATCGACGACCGCGGCCAGGAAGGCCTGGAGCTGGCATTCGACGA
ATGGCTGCGCGGCAAGCCCGGTTCCAAGAAAGTGGTGCGCGATGCGCGCGGCGCCATCGTGGAAAGCGTGGACCTGGTGC
GTCCGGCGCAGCCGGGCAAGGACCTGACGCTGAGCATCGACCGCCGCATCCAGTTCCTTGCCTACAAGGAGCTGCGCAAT
GCCTTGGTCGAGAACAACGCGGCCGGCGGTTCGATGGTGGTGATGGACGTGGCCACCGGCGAAGTGCTGGCGATGGTCAA
CCTGCCTACCTACAACCCCAATTCGGTCACCGGCATCAATCCGTCGGCCCGCCGTAACCGTGCGGTCACCGATCTGGTCG
AGCCGGGTTCGACGATGAAGCCGCTGACCGTGGCCACCGCGCTGACCGCTGGCGTGGTGACCAAGGACACCGTCATCGAT
ACCAACCCCGGCTACATGTCGGTGGGGCGCTTCACCATTCGCGATGTGCCGCGCAACAACGGCGTGCTCAACGTCACCGG
CGTGATCACCCGCAGCTCGAACATCGGTGCGGCCAAGATCGCGGCCAAGGTGCCGGACCAGACCTTCTACCAGTCGATCC
GCAACTTCGGTTACGGCAGTGCGCCGCACAGCGGGTTCCCCGGCGAATCGGCCGGCGTGGTGCTGCAGCCGGCGCGCTGG
AGCGGCCCGTCCAAGACCACGATGTCCTACGGCTACGGCCTGTCGGTGACGCCGCTGCAGATTGCGCAGGCGTACGCCAC
GCTGGGCAACGGCGGCAAGCTCACCCCGCCGACCTTCGTGCGCGGCCAGCACAACGAAACCCGTCAGGTGATCACGCCGG
AAGTGGCGCGCCAGGTCATCGACATGATGGAGACCGTGGTCACCCAGGGCGGCGCCAAGGGCGCGGCAATTCTGGGGTAC
CACGTGGCCGGCAAGACCGGCACGGCGCGCAAGAATGGCGCCAACGGCTACGAGCGCGGGCATTACAACGCCCTGTTCGC
CGGGCTGGTGCCGGCCACGCGCCCGCGCTTTGCCACGGTGATCGTCATCAACGATCCGCAAGGCAAGGTGTATTACGGCG
GCCTGGTGTCGGCGCCGGTGTTCCATCGCGTGATGGAAGGCGCGCTGCGCTTGATGGACGTGCCGCCGGACGATATCCAG
TCGTGGCTGGCCGCACAGGCTGCCGGCAAGACCGGCCAGCCGGTGGTCAAGCCGCAGTCGGTCGATCCGGACCCGGCGCT
GGTGCCGGACCCGGTGGATGAAGTCTCTGCCGGCATCCCGACCGCACTGGCGCCTGCGCCGGCTGCCGCACCAGCGCAGC
CCGCGCCGTTGCAGGAGAGCCGCCAGTGA

Upstream 100 bases:

>100_bases
GGGATGAAGTTCCCGGAGACCAACGACATCGTGGTGGTGCGCCCATGACAAAGCAGCACAGCCGCTTTGCACGGCGCAGC
TGCGCACCGGGAGGTGTGCG

Downstream 100 bases:

>100_bases
GCCGCTCCATGGCGCTCTCGCAGTTGCTGCCGGACGTGGCGTTGACGCACGACGTGCAGGTGTCCGGGCTGGTGATGGAT
AGCCGTGCCGTGCGTCCGGG

Product: penicillin-binding protein 3

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MKAGRNRPRSNFNLRGRLTLVGIALGLCSVTLIGRAAYVQLVNRDFYQRQGEARYLRELPIATSRGMITDRNGEPLAVST
PVESIWVNPQELLRNPDRIPELAKALGQPLDDLNAKLAQKAGKEFMYLQRRINPDKAHAIVDLKIPGVFSQREFRRFYPQ
GEAMAHVLGFTNIDDRGQEGLELAFDEWLRGKPGSKKVVRDARGAIVESVDLVRPAQPGKDLTLSIDRRIQFLAYKELRN
ALVENNAAGGSMVVMDVATGEVLAMVNLPTYNPNSVTGINPSARRNRAVTDLVEPGSTMKPLTVATALTAGVVTKDTVID
TNPGYMSVGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKIAAKVPDQTFYQSIRNFGYGSAPHSGFPGESAGVVLQPARW
SGPSKTTMSYGYGLSVTPLQIAQAYATLGNGGKLTPPTFVRGQHNETRQVITPEVARQVIDMMETVVTQGGAKGAAILGY
HVAGKTGTARKNGANGYERGHYNALFAGLVPATRPRFATVIVINDPQGKVYYGGLVSAPVFHRVMEGALRLMDVPPDDIQ
SWLAAQAAGKTGQPVVKPQSVDPDPALVPDPVDEVSAGIPTALAPAPAAAPAQPAPLQESRQ

Sequences:

>Translated_622_residues
MKAGRNRPRSNFNLRGRLTLVGIALGLCSVTLIGRAAYVQLVNRDFYQRQGEARYLRELPIATSRGMITDRNGEPLAVST
PVESIWVNPQELLRNPDRIPELAKALGQPLDDLNAKLAQKAGKEFMYLQRRINPDKAHAIVDLKIPGVFSQREFRRFYPQ
GEAMAHVLGFTNIDDRGQEGLELAFDEWLRGKPGSKKVVRDARGAIVESVDLVRPAQPGKDLTLSIDRRIQFLAYKELRN
ALVENNAAGGSMVVMDVATGEVLAMVNLPTYNPNSVTGINPSARRNRAVTDLVEPGSTMKPLTVATALTAGVVTKDTVID
TNPGYMSVGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKIAAKVPDQTFYQSIRNFGYGSAPHSGFPGESAGVVLQPARW
SGPSKTTMSYGYGLSVTPLQIAQAYATLGNGGKLTPPTFVRGQHNETRQVITPEVARQVIDMMETVVTQGGAKGAAILGY
HVAGKTGTARKNGANGYERGHYNALFAGLVPATRPRFATVIVINDPQGKVYYGGLVSAPVFHRVMEGALRLMDVPPDDIQ
SWLAAQAAGKTGQPVVKPQSVDPDPALVPDPVDEVSAGIPTALAPAPAAAPAQPAPLQESRQ
>Mature_622_residues
MKAGRNRPRSNFNLRGRLTLVGIALGLCSVTLIGRAAYVQLVNRDFYQRQGEARYLRELPIATSRGMITDRNGEPLAVST
PVESIWVNPQELLRNPDRIPELAKALGQPLDDLNAKLAQKAGKEFMYLQRRINPDKAHAIVDLKIPGVFSQREFRRFYPQ
GEAMAHVLGFTNIDDRGQEGLELAFDEWLRGKPGSKKVVRDARGAIVESVDLVRPAQPGKDLTLSIDRRIQFLAYKELRN
ALVENNAAGGSMVVMDVATGEVLAMVNLPTYNPNSVTGINPSARRNRAVTDLVEPGSTMKPLTVATALTAGVVTKDTVID
TNPGYMSVGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKIAAKVPDQTFYQSIRNFGYGSAPHSGFPGESAGVVLQPARW
SGPSKTTMSYGYGLSVTPLQIAQAYATLGNGGKLTPPTFVRGQHNETRQVITPEVARQVIDMMETVVTQGGAKGAAILGY
HVAGKTGTARKNGANGYERGHYNALFAGLVPATRPRFATVIVINDPQGKVYYGGLVSAPVFHRVMEGALRLMDVPPDDIQ
SWLAAQAAGKTGQPVVKPQSVDPDPALVPDPVDEVSAGIPTALAPAPAAAPAQPAPLQESRQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=567, Percent_Identity=44.4444444444444, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786854, Length=590, Percent_Identity=25.7627118644068, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 66872; Mature: 66872

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAGRNRPRSNFNLRGRLTLVGIALGLCSVTLIGRAAYVQLVNRDFYQRQGEARYLRELP
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
IATSRGMITDRNGEPLAVSTPVESIWVNPQELLRNPDRIPELAKALGQPLDDLNAKLAQK
CCCCCCEEECCCCCCEEEECCHHHHCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHH
AGKEFMYLQRRINPDKAHAIVDLKIPGVFSQREFRRFYPQGEAMAHVLGFTNIDDRGQEG
HCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCH
LELAFDEWLRGKPGSKKVVRDARGAIVESVDLVRPAQPGKDLTLSIDRRIQFLAYKELRN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHH
ALVENNAAGGSMVVMDVATGEVLAMVNLPTYNPNSVTGINPSARRNRAVTDLVEPGSTMK
HHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCC
PLTVATALTAGVVTKDTVIDTNPGYMSVGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKI
CHHHHHHHHHCCEECCEEEECCCCEEEECCEEEEECCCCCCEEEEEEEEEECCCCCHHHH
AAKVPDQTFYQSIRNFGYGSAPHSGFPGESAGVVLQPARWSGPSKTTMSYGYGLSVTPLQ
EECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCHHH
IAQAYATLGNGGKLTPPTFVRGQHNETRQVITPEVARQVIDMMETVVTQGGAKGAAILGY
HHHHHHHCCCCCCCCCCCEECCCCCCCCCEECHHHHHHHHHHHHHHHHCCCCCCEEEEEE
HVAGKTGTARKNGANGYERGHYNALFAGLVPATRPRFATVIVINDPQGKVYYGGLVSAPV
EEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCEEECCHHHHHH
FHRVMEGALRLMDVPPDDIQSWLAAQAAGKTGQPVVKPQSVDPDPALVPDPVDEVSAGIP
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
TALAPAPAAAPAQPAPLQESRQ
CCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MKAGRNRPRSNFNLRGRLTLVGIALGLCSVTLIGRAAYVQLVNRDFYQRQGEARYLRELP
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
IATSRGMITDRNGEPLAVSTPVESIWVNPQELLRNPDRIPELAKALGQPLDDLNAKLAQK
CCCCCCEEECCCCCCEEEECCHHHHCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHH
AGKEFMYLQRRINPDKAHAIVDLKIPGVFSQREFRRFYPQGEAMAHVLGFTNIDDRGQEG
HCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCH
LELAFDEWLRGKPGSKKVVRDARGAIVESVDLVRPAQPGKDLTLSIDRRIQFLAYKELRN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHH
ALVENNAAGGSMVVMDVATGEVLAMVNLPTYNPNSVTGINPSARRNRAVTDLVEPGSTMK
HHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCC
PLTVATALTAGVVTKDTVIDTNPGYMSVGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKI
CHHHHHHHHHCCEECCEEEECCCCEEEECCEEEEECCCCCCEEEEEEEEEECCCCCHHHH
AAKVPDQTFYQSIRNFGYGSAPHSGFPGESAGVVLQPARWSGPSKTTMSYGYGLSVTPLQ
EECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCHHH
IAQAYATLGNGGKLTPPTFVRGQHNETRQVITPEVARQVIDMMETVVTQGGAKGAAILGY
HHHHHHHCCCCCCCCCCCEECCCCCCCCCEECHHHHHHHHHHHHHHHHCCCCCCEEEEEE
HVAGKTGTARKNGANGYERGHYNALFAGLVPATRPRFATVIVINDPQGKVYYGGLVSAPV
EEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCEEECCHHHHHH
FHRVMEGALRLMDVPPDDIQSWLAAQAAGKTGQPVVKPQSVDPDPALVPDPVDEVSAGIP
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
TALAPAPAAAPAQPAPLQESRQ
CCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]