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The map label for this gene is dacC [H]

Identifier: 21241435

GI number: 21241435

Start: 788090

End: 789295

Strand: Direct

Name: dacC [H]

Synonym: XAC0664

Alternate gene names: 21241435

Gene position: 788090-789295 (Clockwise)

Preceding gene: 21241434

Following gene: 21241437

Centisome position: 15.23

GC content: 65.01

Gene sequence:

>1206_bases
ATGAAATTCCGCTTCGCCGCCGCTGCCGTGGCCACGTTCGCCTTCGGCCTGGTCTGCGCCCAGACACCTGCGCCGCAGCC
GACTCCTGCCGTGGCTGCCGCCCCGGTCGCCTTGCCGGTGCCGCCGGCGCCCGCACCGGCCGTGTCCAAGTCCTGGATCC
TGATGGACTACGCCACCGGGCAGGTGCTGGCCGGTGAAAACATCCACCAGCAACTGGCGCCGGCCAGCATCACCAAGGTG
ATGACCTCCTACGTGGTCGCCGCCGAGATCAAGAACGGCAAGGTCAAGCGCGACGACCAGGTCATGATGAGCGAACGTGC
CTGGCGCGAAGGCGGTGCGGGCACCGACGGCAGCTACAGCGGCTTCCCGGTCAACCAGACGGCGCGTCTGGAAGACATGG
AAAAGGGCATGGCGATCCAGTCCGGCAACGATGCCGCCATCGCGCTGGCCGAGCATGTGGCCGGCAGCGAAGAAGCCTTC
GCCTCGCTGATGAACAGCTACGCCGCCAAGATCGGCATGAAGGATTCGTACTTCGTCAACGCGCACGGCCTGAGCGCCGA
AGGGCATCACTCCACCGCCTACGACCTGGCCCTGCTGGGCCGCGCGATGGTGCGCGATTACCCGGAAACCTACGCCTACA
ACAAGATCAAGGAATTTCAGGTCGGCACCATCAAGCAGAGCAACCGTAACCGGCTGCTGTGGCGCGACCCGGCCGTGGAC
GGCATCAAGACCGGTCACACCTCCGAAGCCGGCTACTGCCTGCTGAGCTCGGCCAAGCGCGGCGATCAGCGTTTGATCGC
CGTGGTCATGGGCGACAGCTCCGAAGAACAGCGTGCCACCGATAGCCTGGCGCTGCTCAACTGGGGCTTCCGCTTCTTCG
AAACCCACAGCCTGTACGCGCCCGGCAAGGTCGTCACCAAGCAGAAGGTCTGGAAGGGTCAGCAGGACGAAGTGCAGCTC
GGCGTGGCACAGCCGTTGCTGGTCAGCCTGCAGCGCGGCCGCTACAACGACCTCAAGCCCAGCATGGAAGTGCCCAAGAA
CCTGCAGGCGCCGATCAAGCAGGGCCAGCAGGTTGGCACCGTGAAGGTCAGCCTGGACGGTAAGGTCATCGCCCAGGCCC
CGCTGGTCGCCATCAACGCCGTCGAAGAAGGCGGATTCTTCAAGCGCCTCTGGGACGCGTTCTGGATGTGGTGGGAATCG
GAGTAA

Upstream 100 bases:

>100_bases
TGCGCAAGCGCGCGCATCGTGCAACGCGTCGCCCTGATCGCCGTGGCGTCTTACAATTTCGCATTGCCCGGCGTTCGGGC
CCGTCAGGAGTCGTTCTTCA

Downstream 100 bases:

>100_bases
AGAAAATGCCGGCGAAAGCCGGCATTTTTTTTGGAATCGGGAATTGAGAGTCGGGAATGGTTAGACGCCAGGCACAGCCT
TGGCTTTTGCGATTCCCGAT

Product: penicillin-binding protein 6

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKFRFAAAAVATFAFGLVCAQTPAPQPTPAVAAAPVALPVPPAPAPAVSKSWILMDYATGQVLAGENIHQQLAPASITKV
MTSYVVAAEIKNGKVKRDDQVMMSERAWREGGAGTDGSYSGFPVNQTARLEDMEKGMAIQSGNDAAIALAEHVAGSEEAF
ASLMNSYAAKIGMKDSYFVNAHGLSAEGHHSTAYDLALLGRAMVRDYPETYAYNKIKEFQVGTIKQSNRNRLLWRDPAVD
GIKTGHTSEAGYCLLSSAKRGDQRLIAVVMGDSSEEQRATDSLALLNWGFRFFETHSLYAPGKVVTKQKVWKGQQDEVQL
GVAQPLLVSLQRGRYNDLKPSMEVPKNLQAPIKQGQQVGTVKVSLDGKVIAQAPLVAINAVEEGGFFKRLWDAFWMWWES
E

Sequences:

>Translated_401_residues
MKFRFAAAAVATFAFGLVCAQTPAPQPTPAVAAAPVALPVPPAPAPAVSKSWILMDYATGQVLAGENIHQQLAPASITKV
MTSYVVAAEIKNGKVKRDDQVMMSERAWREGGAGTDGSYSGFPVNQTARLEDMEKGMAIQSGNDAAIALAEHVAGSEEAF
ASLMNSYAAKIGMKDSYFVNAHGLSAEGHHSTAYDLALLGRAMVRDYPETYAYNKIKEFQVGTIKQSNRNRLLWRDPAVD
GIKTGHTSEAGYCLLSSAKRGDQRLIAVVMGDSSEEQRATDSLALLNWGFRFFETHSLYAPGKVVTKQKVWKGQQDEVQL
GVAQPLLVSLQRGRYNDLKPSMEVPKNLQAPIKQGQQVGTVKVSLDGKVIAQAPLVAINAVEEGGFFKRLWDAFWMWWES
E
>Mature_401_residues
MKFRFAAAAVATFAFGLVCAQTPAPQPTPAVAAAPVALPVPPAPAPAVSKSWILMDYATGQVLAGENIHQQLAPASITKV
MTSYVVAAEIKNGKVKRDDQVMMSERAWREGGAGTDGSYSGFPVNQTARLEDMEKGMAIQSGNDAAIALAEHVAGSEEAF
ASLMNSYAAKIGMKDSYFVNAHGLSAEGHHSTAYDLALLGRAMVRDYPETYAYNKIKEFQVGTIKQSNRNRLLWRDPAVD
GIKTGHTSEAGYCLLSSAKRGDQRLIAVVMGDSSEEQRATDSLALLNWGFRFFETHSLYAPGKVVTKQKVWKGQQDEVQL
GVAQPLLVSLQRGRYNDLKPSMEVPKNLQAPIKQGQQVGTVKVSLDGKVIAQAPLVAINAVEEGGFFKRLWDAFWMWWES
E

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=357, Percent_Identity=49.0196078431373, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1786851, Length=363, Percent_Identity=43.801652892562, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI87082022, Length=360, Percent_Identity=40.5555555555556, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082054, Length=247, Percent_Identity=28.7449392712551, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43569; Mature: 43569

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRFAAAAVATFAFGLVCAQTPAPQPTPAVAAAPVALPVPPAPAPAVSKSWILMDYATG
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCCCCCCCCCCCCEEEEEECCC
QVLAGENIHQQLAPASITKVMTSYVVAAEIKNGKVKRDDQVMMSERAWREGGAGTDGSYS
CEEECCCHHHHHCHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GFPVNQTARLEDMEKGMAIQSGNDAAIALAEHVAGSEEAFASLMNSYAAKIGMKDSYFVN
CCCCCCCHHHHHHHCCCEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
AHGLSAEGHHSTAYDLALLGRAMVRDYPETYAYNKIKEFQVGTIKQSNRNRLLWRDPAVD
ECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEECCCCCEEEEECCCCC
GIKTGHTSEAGYCLLSSAKRGDQRLIAVVMGDSSEEQRATDSLALLNWGFRFFETHSLYA
CCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHEEECCCCCC
PGKVVTKQKVWKGQQDEVQLGVAQPLLVSLQRGRYNDLKPSMEVPKNLQAPIKQGQQVGT
CCCCEEHHHHHCCCCCCEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEE
VKVSLDGKVIAQAPLVAINAVEEGGFFKRLWDAFWMWWESE
EEEEECCEEEECCCEEEEEEECCCCHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKFRFAAAAVATFAFGLVCAQTPAPQPTPAVAAAPVALPVPPAPAPAVSKSWILMDYATG
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCCCCCCCCCCCCEEEEEECCC
QVLAGENIHQQLAPASITKVMTSYVVAAEIKNGKVKRDDQVMMSERAWREGGAGTDGSYS
CEEECCCHHHHHCHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GFPVNQTARLEDMEKGMAIQSGNDAAIALAEHVAGSEEAFASLMNSYAAKIGMKDSYFVN
CCCCCCCHHHHHHHCCCEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
AHGLSAEGHHSTAYDLALLGRAMVRDYPETYAYNKIKEFQVGTIKQSNRNRLLWRDPAVD
ECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEECCCCCEEEEECCCCC
GIKTGHTSEAGYCLLSSAKRGDQRLIAVVMGDSSEEQRATDSLALLNWGFRFFETHSLYA
CCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHEEECCCCCC
PGKVVTKQKVWKGQQDEVQLGVAQPLLVSLQRGRYNDLKPSMEVPKNLQAPIKQGQQVGT
CCCCEEHHHHHCCCCCCEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEE
VKVSLDGKVIAQAPLVAINAVEEGGFFKRLWDAFWMWWESE
EEEEECCEEEECCCEEEEEEECCCCHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]