Click here to switch to the map view.

The map label for this gene is mltB [H]

Identifier: 21241433

GI number: 21241433

Start: 785110

End: 786249

Strand: Direct

Name: mltB [H]

Synonym: XAC0662

Alternate gene names: 21241433

Gene position: 785110-786249 (Clockwise)

Preceding gene: 21241432

Following gene: 21241434

Centisome position: 15.17

GC content: 66.49

Gene sequence:

>1140_bases
ATGATTCGACGCACCCTGACCTGCCTGCTCACCCTCGGCCTTGTCGCCTGCGCGACCCAGCCCAGCCCTCCGTCCCCGCC
ACCGGCCGCCAGCGCGCCGCCGGCCAAGCCACCGGTTGCGCCAACCCCGCCCGCAAGCGCCGCCGCCGAGGCGCCTGCGC
TTCCGCCAGTCGACCTGACCCCGGTCCCGTTCGAGATCGCCCGCGCCAACTTCGTGCGCGACACCTCGGCCAAGTACGGC
ATCGATGCCGCGCAGATCGAAGCGGTGCTGGCGCAGGCGCAATTCAAGGACGCCATTGTCACTGCGATGTCGCGCCCGGC
CGAACGGGTCAAGCCGTGGAACGAATACCGGCCGATGTTCATCACCCAGGCGCGTATCGACGGCGGCCGCAAGTTTCTCG
CCGAACATCGCGCCGAGCTGAGCAAGGTCGAAGCGGCCACCGGTGTGCCGGCACAGGTGATCGTCGCCATCATCGGGGTG
GAAACCAGCTACGGCAGCAACGCCGGCAAGTACCGCGTGCTGGACGCGCTGTACACGCTGGCGTTCCGCTATCCGCGCAG
CGGCGACCCGGCCAAGCTCGAGCGCGAAGTGCGCCGCGAACTGTTTTTCCGCGACGAACTCGGCCAGTTGTTCGCGCTCG
GCAAGGAAGAGCAACTCGACGTCACCACCCTGATCGGCAGCTATGCCGGCGCAATGGGCATGGGCCAGTTCATGCCGTCC
AGCTATCGCCAGTTCGGCGTGGACGGCGATGCCGACGGCAAGCGCAATTTGTTCACCGACTACAACGACGTGTTCGCCTC
GATCGCCAACTACTTCGTCAAGAAGGGCGGCTGGGTGCGTGGCGGGCAGGTCGCGGTGCCGGCCACGCTGGCCGCTGGGC
ACGAAGAATTCAATCCCACCGACTGGTCGCCGGTGTACACGCTGTCCGAGCTGTCGGCGCGCGGCTATCACCCGAGCGCA
CCGGTGGTGGCCGGCAGCACCGCCACCCCGATCAGCCTGGACGACGCCAACGGCAAGCAGTATTGGCTGGGCTTCCAGAA
CTTTTATGCGATCACCCGTTACAACATTTCCAAGATGTATGCGATGGCCGTGTTCCAGCTGTCCGAGGCCATCGCCGGCA
AGGAGTTACCCCCGGCATGA

Upstream 100 bases:

>100_bases
ATCCCCTGCCGCACACGCGGCAGGCTTGACTTTGACTAAAGTCTTTTCGTTTCATGGCCTTATTGCCAGAAGTTCATCTG
ATGTCTGTTACCCTCGGCCG

Downstream 100 bases:

>100_bases
ACAGCATTGCAGGCCCCAAGTGGCTGATCCCGATGGCGCTGATGCTTGGCCTGGCGTCCTGTAGCAGCGCACCGAAGAAA
ACTGCCGGCGGCAACGGCAG

Product: membrane-bound lytic transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MIRRTLTCLLTLGLVACATQPSPPSPPPAASAPPAKPPVAPTPPASAAAEAPALPPVDLTPVPFEIARANFVRDTSAKYG
IDAAQIEAVLAQAQFKDAIVTAMSRPAERVKPWNEYRPMFITQARIDGGRKFLAEHRAELSKVEAATGVPAQVIVAIIGV
ETSYGSNAGKYRVLDALYTLAFRYPRSGDPAKLEREVRRELFFRDELGQLFALGKEEQLDVTTLIGSYAGAMGMGQFMPS
SYRQFGVDGDADGKRNLFTDYNDVFASIANYFVKKGGWVRGGQVAVPATLAAGHEEFNPTDWSPVYTLSELSARGYHPSA
PVVAGSTATPISLDDANGKQYWLGFQNFYAITRYNISKMYAMAVFQLSEAIAGKELPPA

Sequences:

>Translated_379_residues
MIRRTLTCLLTLGLVACATQPSPPSPPPAASAPPAKPPVAPTPPASAAAEAPALPPVDLTPVPFEIARANFVRDTSAKYG
IDAAQIEAVLAQAQFKDAIVTAMSRPAERVKPWNEYRPMFITQARIDGGRKFLAEHRAELSKVEAATGVPAQVIVAIIGV
ETSYGSNAGKYRVLDALYTLAFRYPRSGDPAKLEREVRRELFFRDELGQLFALGKEEQLDVTTLIGSYAGAMGMGQFMPS
SYRQFGVDGDADGKRNLFTDYNDVFASIANYFVKKGGWVRGGQVAVPATLAAGHEEFNPTDWSPVYTLSELSARGYHPSA
PVVAGSTATPISLDDANGKQYWLGFQNFYAITRYNISKMYAMAVFQLSEAIAGKELPPA
>Mature_379_residues
MIRRTLTCLLTLGLVACATQPSPPSPPPAASAPPAKPPVAPTPPASAAAEAPALPPVDLTPVPFEIARANFVRDTSAKYG
IDAAQIEAVLAQAQFKDAIVTAMSRPAERVKPWNEYRPMFITQARIDGGRKFLAEHRAELSKVEAATGVPAQVIVAIIGV
ETSYGSNAGKYRVLDALYTLAFRYPRSGDPAKLEREVRRELFFRDELGQLFALGKEEQLDVTTLIGSYAGAMGMGQFMPS
SYRQFGVDGDADGKRNLFTDYNDVFASIANYFVKKGGWVRGGQVAVPATLAAGHEEFNPTDWSPVYTLSELSARGYHPSA
PVVAGSTATPISLDDANGKQYWLGFQNFYAITRYNISKMYAMAVFQLSEAIAGKELPPA

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=380, Percent_Identity=37.8947368421053, Blast_Score=224, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40901; Mature: 40901

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRTLTCLLTLGLVACATQPSPPSPPPAASAPPAKPPVAPTPPASAAAEAPALPPVDLT
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVPFEIARANFVRDTSAKYGIDAAQIEAVLAQAQFKDAIVTAMSRPAERVKPWNEYRPMF
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHCCCEE
ITQARIDGGRKFLAEHRAELSKVEAATGVPAQVIVAIIGVETSYGSNAGKYRVLDALYTL
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AFRYPRSGDPAKLEREVRRELFFRDELGQLFALGKEEQLDVTTLIGSYAGAMGMGQFMPS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCH
SYRQFGVDGDADGKRNLFTDYNDVFASIANYFVKKGGWVRGGQVAVPATLAAGHEEFNPT
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHCCCCCCCCC
DWSPVYTLSELSARGYHPSAPVVAGSTATPISLDDANGKQYWLGFQNFYAITRYNISKMY
CCCHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCCEEEEEHHHEEEEEHHHHHHHH
AMAVFQLSEAIAGKELPPA
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIRRTLTCLLTLGLVACATQPSPPSPPPAASAPPAKPPVAPTPPASAAAEAPALPPVDLT
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVPFEIARANFVRDTSAKYGIDAAQIEAVLAQAQFKDAIVTAMSRPAERVKPWNEYRPMF
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHCCCEE
ITQARIDGGRKFLAEHRAELSKVEAATGVPAQVIVAIIGVETSYGSNAGKYRVLDALYTL
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AFRYPRSGDPAKLEREVRRELFFRDELGQLFALGKEEQLDVTTLIGSYAGAMGMGQFMPS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCH
SYRQFGVDGDADGKRNLFTDYNDVFASIANYFVKKGGWVRGGQVAVPATLAAGHEEFNPT
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHCCCCCCCCC
DWSPVYTLSELSARGYHPSAPVVAGSTATPISLDDANGKQYWLGFQNFYAITRYNISKMY
CCCHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCCEEEEEHHHEEEEEHHHHHHHH
AMAVFQLSEAIAGKELPPA
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]